Q7W7P9 (GCH4_BORPA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GTP cyclohydrolase folE2
EC=3.5.4.16

Gene names

Name:	folE2
Ordered Locus Names:	BPP2465

Organism

Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253) [Complete proteome] [HAMAP]

Taxonomic identifier

257311 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella › Bordetella parapertussis

Protein attributes

Sequence length	265 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Converts GTP to 7,8-dihydroneopterin triphosphate By similarity. HAMAP-Rule MF_01527
Catalytic activity	GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_01527
Pathway	Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_01527
Sequence similarities	Belongs to the GTP cyclohydrolase IV family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	7,8-dihydroneopterin 3'-triphosphate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	GTP cyclohydrolase I activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 265	265	GTP cyclohydrolase folE2 HAMAP-Rule MF_01527		PRO_0000147704
Sites
	Site	156	1	May be catalytically important By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7W7P9 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 4B4F4387ED84A0B6	FASTA	265	29,365
	10 20 30 40 50 60 MNSPIDPAIV MPDVQSSTDT RHIPIQRVGI RGVRHPMLVL AGDGAAQPTV ANWTLTVALP 70 80 90 100 110 120 AEEKGTHMSR FVALLEKYRA TPMTPALFAA MAREMLPLLH AERGDITASF PYFINKSAPV 130 140 150 160 170 180 SGVQSLLDYE MQWIARAVGE QVEFELVAQV PVTSLCPCSK AISEYGAHNQ RSHVTVSAIV 190 200 210 220 230 240 DGDFRMDELI RLVEDEASCE LWGLLKRPDE KYVTERAYDN PKFVEDLVRD VAARLKAHPG 250 260 IGRFRVEAEN FESIHNHSAY AVVEG

References

[1]

"Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica." Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S. , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J. Nat. Genet. 35:32-40(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 12822 / ATCC BAA-587 / NCTC 13253.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX640430 Genomic DNA. Translation: CAE37760.1.
RefSeq	NP_884696.1. NC_002928.3.
3D structure databases
ProteinModelPortal	Q7W7P9.
SMR	Q7W7P9. Positions 22-264.
ModBase	Search...
Protein-protein interaction databases
STRING	257311.BPP2465.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAE37760; CAE37760; BPP2465.
GeneID	1664856.
KEGG	bpa:BPP2465.
PATRIC	21148809. VBIBorPar43418_2589.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1469.
HOGENOM	HOG000280679.
KO	K09007.
OMA	IAMTACP.
ProtClustDB	PRK13674.
Enzyme and pathway databases
BioCyc	BPAR257311:BPP2465-MONOMER.
UniPathway	UPA00848; UER00151.
Family and domain databases
Gene3D	3.10.270.10. 1 hit.
HAMAP	MF_01527_B. GTP_cyclohydrol_B.
InterPro	IPR022838. GTP_cyclohydrolase_FolE2. IPR003801. GTP_cyclohydrolase_FolE2/MptA. IPR002042. Uricase. [Graphical view]
Pfam	PF02649. GCHY-1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCH4_BORPA

Accession

Primary (citable) accession number: Q7W7P9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	October 1, 2003
Last modified:	May 1, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program