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Q7W7F9 (KDSB_BORPA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3-deoxy-manno-octulosonate cytidylyltransferase

EC=2.7.7.38
Alternative name(s):
CMP-2-keto-3-deoxyoctulosonic acid synthase
Short name=CKS
Short name=CMP-KDO synthase
Gene names
Name:kdsB
Ordered Locus Names:BPP2561
OrganismBordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253) [Complete proteome] [HAMAP]
Taxonomic identifier257311 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella

Protein attributes

Sequence length254 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria By similarity. HAMAP-Rule MF_00057

Catalytic activity

CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate. HAMAP-Rule MF_00057

Pathway

Nucleotide-sugar biosynthesis; CMP-3-deoxy-D-manno-octulosonate biosynthesis; CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP: step 1/1. HAMAP-Rule MF_00057

Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. HAMAP-Rule MF_00057

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00057.

Sequence similarities

Belongs to the KdsB family.

Ontologies

Keywords
   Biological processLipopolysaccharide biosynthesis
   Cellular componentCytoplasm
   Molecular functionNucleotidyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processCMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

keto-3-deoxy-D-manno-octulosonic acid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_function3-deoxy-manno-octulosonate cytidylyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2542543-deoxy-manno-octulosonate cytidylyltransferase HAMAP-Rule MF_00057
PRO_1000091861

Sequences

Sequence LengthMass (Da)Tools
Q7W7F9 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 7B31B80539954953

FASTA25427,060
        10         20         30         40         50         60 
MSFTVLIPAR LASTRLPDKP LADIAGKPMV VRVAERAALS GAERVMIATD DARVQQAAAD 

        70         80         90        100        110        120 
HGHAAILTRP DHPTGTDRLS EAVDALGLPD DAIVVNVQGD EPLIEPALID AVAAQLVAAP 

       130        140        150        160        170        180 
HADIATCACP LADAEALFNP NVVKVVCAAD RRALYFSRAP IPWARDALAG GARVLAPGLP 

       190        200        210        220        230        240 
AWHHIGIYAY RVAFLRRFPA LSQGQLERYE SLEQLRAMEH GHVIVVHHTD SAPAAGVDTP 

       250 
ADLERARAAY TNRL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX640430 Genomic DNA. Translation: CAE37855.1.
RefSeqNP_884789.1. NC_002928.3.

3D structure databases

ProteinModelPortalQ7W7F9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING257311.BPP2561.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE37855; CAE37855; BPP2561.
GeneID1666232.
KEGGbpa:BPP2561.
PATRIC21149013. VBIBorPar43418_2687.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1212.
HOGENOMHOG000007602.
KOK00979.
OMADDQRIAD.
OrthoDBEOG6KT2SK.

Enzyme and pathway databases

BioCycBPAR257311:BPP2561-MONOMER.
UniPathwayUPA00030.
UPA00358; UER00476.

Family and domain databases

Gene3D3.90.550.10. 1 hit.
HAMAPMF_00057. CMP_KDO_synth.
InterProIPR003329. Cytidylyl_trans.
IPR004528. KdsB.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERPTHR21485:SF4. PTHR21485:SF4. 1 hit.
PfamPF02348. CTP_transf_3. 1 hit.
[Graphical view]
SUPFAMSSF53448. SSF53448. 1 hit.
TIGRFAMsTIGR00466. kdsB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKDSB_BORPA
AccessionPrimary (citable) accession number: Q7W7F9
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: October 1, 2003
Last modified: June 11, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways