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Q7W6C6 (NTPA_BORPA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Non-canonical purine NTP pyrophosphatase

EC=3.6.1.19
Alternative name(s):
Non-standard purine NTP pyrophosphatase
Nucleoside-triphosphate diphosphatase
Nucleoside-triphosphate pyrophosphatase
Short name=NTPase
Gene names
Ordered Locus Names:BPP2990
OrganismBordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253) [Complete proteome] [HAMAP]
Taxonomic identifier257311 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella

Protein attributes

Sequence length213 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions By similarity. HAMAP-Rule MF_01405

Catalytic activity

A nucleoside triphosphate + H2O = a nucleotide + diphosphate. HAMAP-Rule MF_01405

Cofactor

Binds 1 divalent metal cation ion per subunit; can use either magnesium or manganese By similarity.

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01405

Sequence similarities

Belongs to the HAM1 NTPase family.

Sequence caution

The sequence CAE38280.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 213213Non-canonical purine NTP pyrophosphatase HAMAP-Rule MF_01405
PRO_0000178138

Regions

Region17 – 226Substrate binding By similarity
Region78 – 792Substrate binding By similarity

Sites

Metal binding781Magnesium or manganese By similarity
Binding site1671Substrate By similarity
Binding site1871Substrate By similarity
Binding site1931Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7W6C6 [UniParc].

Last modified April 26, 2005. Version 2.
Checksum: B6D8C8812EC4C174

FASTA21322,532
        10         20         30         40         50         60 
MSAEILNPNL RRVVLASNNA GKLREFSALF APLGIELVPQ SELGVSEAAE PHATFVENAL 

        70         80         90        100        110        120 
AKARHASRHT GLPALADDSG LCVVALGGAP GVHSARYAQQ PGGARSDAAN NALLVRELAA 

       130        140        150        160        170        180 
AGDRRAWYVA LLALVRTEND PCPLIGEGLW HGEIVDAPAG EHGFGYDPHF YLPQQGCTAA 

       190        200        210 
QLAPEHKNRI SHRAQALAQL LDKLRATGPV DRP 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX640432 Genomic DNA. Translation: CAE38280.1. Different initiation.
RefSeqNP_885177.1. NC_002928.3.

3D structure databases

ProteinModelPortalQ7W6C6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING257311.BPP2990.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE38280; CAE38280; BPP2990.
GeneID1666502.
KEGGbpa:BPP2990.
PATRIC21149931. VBIBorPar43418_3141.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0127.
HOGENOMHOG000293319.
KOK02428.
OrthoDBEOG6CZQQP.
ProtClustDBPRK00120.

Enzyme and pathway databases

BioCycBPAR257311:BPP2990-MONOMER.

Family and domain databases

HAMAPMF_01405. Non_canon_purine_NTPase.
InterProIPR002637. Ham1p-like.
IPR020922. NTPase.
[Graphical view]
PANTHERPTHR11067. PTHR11067. 1 hit.
PfamPF01725. Ham1p_like. 1 hit.
[Graphical view]
TIGRFAMsTIGR00042. TIGR00042. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNTPA_BORPA
AccessionPrimary (citable) accession number: Q7W6C6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: February 19, 2014
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families