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Q7W5Z9 (SERC_BORPA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoserine aminotransferase
EC=2.6.1.52
Alternative name(s):
Phosphohydroxythreonine aminotransferase
Short name=PSAT
Gene names
Name:serC
Ordered Locus Names:BPP3133
OrganismBordetella parapertussis [Complete proteome] [HAMAP]
Taxonomic identifier519 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length377 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine By similarity. HAMAP MF_00160

Catalytic activity

O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate. HAMAP MF_00160

4-phosphonooxy-L-threonine + 2-oxoglutarate = (3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + L-glutamate. HAMAP MF_00160

Cofactor

Binds 1 pyridoxal phosphate per subunit By similarity. HAMAP MF_00160

Pathway

Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3. HAMAP MF_00160

Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 3/5. HAMAP MF_00160

Subunit structure

Homodimer By similarity. HAMAP MF_00160

Subcellular location

Cytoplasm By similarity HAMAP MF_00160.

Sequence similarities

Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 377377Phosphoserine aminotransferase HAMAP MF_00160
PRO_0000150156

Regions

Region254 – 2552Pyridoxal phosphate binding By similarity

Sites

Binding site431L-glutamate By similarity
Binding site1051Pyridoxal phosphate By similarity
Binding site1641Pyridoxal phosphate By similarity
Binding site1891Pyridoxal phosphate By similarity
Binding site2121Pyridoxal phosphate By similarity

Amino acid modifications

Modified residue2131N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7W5Z9 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 2E9141F5104B889D

FASTA37740,869
        10         20         30         40         50         60 
MMARPWNFSA GPSALPEAVL QQAAAEMLDW HGSGMSVMEM SHRGKHFVQI CDEAEADLRE 

        70         80         90        100        110        120 
LLGLPADYAV MFMQGGGLGE NAIVPMNLMG RRSTPAADFV VTGHWSTRSH KEAGRYGDAQ 

       130        140        150        160        170        180 
IAASAAEATE IDGQAQSSWT WLPPVDTWRV RKDSAYLHLC SNETIGGVEF TEWPDPASLG 

       190        200        210        220        230        240 
APDVPLVVDV SSHFLSRPLD IARAGLVFAG AQKNAGPAGV TVVIARRDLL GHALPICPSA 

       250        260        270        280        290        300 
FDYANVAADH SRYNTPPTFA IYVMGLVFKW IKAHGGVRGM EEANRAKAEL LYGYLDGSAF 

       310        320        330        340        350        360 
YRNPVQPAVR SRMNVPFVLR DESLNDAFLQ GAEAAGLMQL KGHKSVGGMR ASIYNAMPLA 

       370 
GVQALIDYLK EFERRHG

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX640432 Genomic DNA. Translation: CAE38418.1.
RefSeqNP_885308.1. NC_002928.3.

3D structure databases

ProteinModelPortalQ7W5Z9.
SMRQ7W5Z9. Positions 5-377.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1666661.
GenomeReviewsGene locus BPP3133 in contig BX470249_GR.
KEGGbpa:BPP3133.
PATRIC21150227. VBIBorPar43418_3289.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG289982.
OMAYEVLFLQ.
PhylomeDBQ7W5Z9.
ProtClustDBPRK05355.

Enzyme and pathway databases

BioCycBPAR257311:BPP3133-MONOMER.

Family and domain databases

HAMAPMF_00160. SerC_aminotrans_5.
[Tree]
InterProIPR000192. Aminotrans_V/Cys_dSase.
IPR022278. Pser_aminoTfrase.
IPR003248. Pser_aminoTfrase_subgr.
IPR015424. PyrdxlP-dep_Trfase_major_dom.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
Gene3DG3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
KOK00831.
PANTHERPTHR21152:SF1. PTHR21152:SF1. 1 hit.
PfamPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFPIRSF000525. SerC. 1 hit.
SUPFAMSSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMsTIGR01364. SerC_1. 1 hit.
PROSITEPS00595. AA_TRANSFER_CLASS_5. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSERC_BORPA
AccessionPrimary (citable) accession number: Q7W5Z9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: October 1, 2003
Last modified: January 25, 2012
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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