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Q7W570 (PNP_BORPA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Polyribonucleotide nucleotidyltransferase

EC=2.7.7.8
Alternative name(s):
Polynucleotide phosphorylase
Short name=PNPase
Gene names
Name:pnp
Ordered Locus Names:BPP3431
OrganismBordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253) [Complete proteome] [HAMAP]
Taxonomic identifier257311 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella

Protein attributes

Sequence length719 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity. HAMAP-Rule MF_01595

Catalytic activity

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate. HAMAP-Rule MF_01595

Cofactor

Magnesium By similarity. HAMAP-Rule MF_01595

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01595.

Sequence similarities

Belongs to the polyribonucleotide nucleotidyltransferase family.

Contains 1 KH domain.

Contains 1 S1 motif domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 719719Polyribonucleotide nucleotidyltransferase HAMAP-Rule MF_01595
PRO_0000329537

Regions

Domain558 – 61760KH
Domain627 – 69569S1 motif

Sites

Metal binding4911Magnesium By similarity
Metal binding4971Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7W570 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: F724544F0DEA6EC4

FASTA71977,342
        10         20         30         40         50         60 
MFNKVTKTFQ YGQHSVVLET GEMARQASGA VLVSVEDTVV LATVVAAKKA KAGQDFFPLT 

        70         80         90        100        110        120 
VDYIEKTYAA GRIPGGFFKR EGKPSEKETL TSRLIDRPLR PLFPEGFYND VQVVIHTLSV 

       130        140        150        160        170        180 
NPDIDPDIPA MIGASAALAI SGIPFNGPIG AARVGYVDGQ YVLNPTATQL KSSKMDLVVA 

       190        200        210        220        230        240 
GTENAVLMVE SEAKQLSEEI MLGGVVFGHE QMQAAINAIH DLVRDAGKPD WDWQPAPKNE 

       250        260        270        280        290        300 
ALIAAVSAAA QEGLNAAYQI REKQARTTKL REVYAAVQAA MAEQAAQAGQ PAPDSVGVDN 

       310        320        330        340        350        360 
ILFDLEARIV RSQILNGEPR IDGRDTRTVR PISIRLGVLP RAHGSALFTR GETQALVVAT 

       370        380        390        400        410        420 
LGTKQDEQII DALMGEYRDR FMLHYNMPPF ATGETGRIGV PKRREIGHGR LAKRALLPLL 

       430        440        450        460        470        480 
PAPEDFQYTI RLVSEITESN GSSSMASVCG GSLAMMDAGV PTNDHVAGVA MGLILDSGKF 

       490        500        510        520        530        540 
AVLTDILGDE DHLGDMDFKV AGTETGITAL QMDIKIQGIT KEIMQVALAQ AREGRLHILG 

       550        560        570        580        590        600 
KMRDALEGSR TELSAFAPRM LTIKINPEKI RDVIGKGGAT IRALTEETGT QIDISDDGTI 

       610        620        630        640        650        660 
VIASVDETQA KEAQRRIVEL TADVEVGQIY DGSVLRLLDF GAIVQVLPGR DGLLHISEIA 

       670        680        690        700        710 
NYRIANINDV LKVGQPVRVK VIEADDKGRL RLSIKAIGGI EQQQSGTAEP AAQSEPQAE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX640433 Genomic DNA. Translation: CAE38716.1.
RefSeqNP_885592.1. NC_002928.3.

3D structure databases

ProteinModelPortalQ7W570.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING257311.BPP3431.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE38716; CAE38716; BPP3431.
GeneID1667399.
KEGGbpa:BPP3431.
PATRIC21150857. VBIBorPar43418_3601.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1185.
HOGENOMHOG000218326.
KOK00962.
OMAPRWDWVA.
OrthoDBEOG6WT8CC.

Enzyme and pathway databases

BioCycBPAR257311:BPP3431-MONOMER.

Family and domain databases

Gene3D1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPMF_01595. PNPase.
InterProIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERPTHR11252. PTHR11252. 1 hit.
PfamPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFPIRSF005499. PNPase. 1 hit.
SMARTSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsTIGR03591. polynuc_phos. 1 hit.
PROSITEPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePNP_BORPA
AccessionPrimary (citable) accession number: Q7W570
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 1, 2003
Last modified: May 14, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families