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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylformylglycinamidine synthase (purL)
  2. Phosphoribosylformylglycinamidine cyclo-ligase (purM)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
Ordered Locus Names:BPP3625
OrganismiBordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)
Taxonomic identifieri257311 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
Proteomesi
  • UP000001421 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001482001 – 349Phosphoribosylformylglycinamidine cyclo-ligaseAdd BLAST349

Structurei

3D structure databases

ProteinModelPortaliQ7W4N4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000229090.
KOiK01933.
OMAiLNRHDTV.

Family and domain databases

CDDicd02196. PurM. 1 hit.
Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741. AIRS. 1 hit.
InterProiIPR010918. AIR_synth_C_dom.
IPR016188. PurM-like_N.
IPR004733. PurM_cligase.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7W4N4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNQHSAPLT YRDAGVDIDA GDALVDRIKP LAARTMRPGV LVGIGGFGAL
60 70 80 90 100
FEVPKKFREP VLVSGTDGVG TKLRLAFDWN RHDTVGIDLV AMSVNDILVQ
110 120 130 140 150
GAEPLYFLDY FACGKLSVDT AAAVVGGIAR GCELAGCALI GGETAEMPGM
160 170 180 190 200
YPDGEYDLAG FAVGAVDKSA IIDGKSIQPG DVVLGLASSG AHSNGYSLVR
210 220 230 240 250
KILERAGARP DQDFHGQPLV DVVMAPTRIY VKQVLAALDR HGPAIKGLAH
260 270 280 290 300
ITGGGLLDNV PRILQPGMAA QLQRDGWEMP KLFQWLQQQG SVADAEMHRV
310 320 330 340
FNCGIGMVLV VAADQADAVA ATLREQGEIV NRIGEIVPQQ DGMAQTVVV
Length:349
Mass (Da):36,818
Last modified:October 1, 2003 - v1
Checksum:iE53BF6EBE7D20D67
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640434 Genomic DNA. Translation: CAE38909.1.
RefSeqiWP_010929162.1. NC_002928.3.

Genome annotation databases

EnsemblBacteriaiCAE38909; CAE38909; BPP3625.
KEGGibpa:BPP3625.
PATRICi21151273. VBIBorPar43418_3805.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640434 Genomic DNA. Translation: CAE38909.1.
RefSeqiWP_010929162.1. NC_002928.3.

3D structure databases

ProteinModelPortaliQ7W4N4.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAE38909; CAE38909; BPP3625.
KEGGibpa:BPP3625.
PATRICi21151273. VBIBorPar43418_3805.

Phylogenomic databases

HOGENOMiHOG000229090.
KOiK01933.
OMAiLNRHDTV.

Enzyme and pathway databases

UniPathwayiUPA00074; UER00129.

Family and domain databases

CDDicd02196. PurM. 1 hit.
Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741. AIRS. 1 hit.
InterProiIPR010918. AIR_synth_C_dom.
IPR016188. PurM-like_N.
IPR004733. PurM_cligase.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPUR5_BORPA
AccessioniPrimary (citable) accession number: Q7W4N4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: October 1, 2003
Last modified: November 2, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.