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Q7W400 (GLYA2_BORPA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Pyridoxal-phosphate-dependent serine hydroxymethyltransferase 2
Short name=SHMT 2
Short name=Serine methylase 2
EC=2.1.2.1
Gene names
Name:glyA2
Ordered Locus Names:BPP3875
OrganismBordetella parapertussis [Complete proteome] [HAMAP]
Taxonomic identifier519 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length415 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate serving as the one-carbon carrier By similarity.

Catalytic activity

5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. HAMAP MF_00051

Cofactor

Pyridoxal phosphate By similarity. HAMAP MF_00051

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_00051

Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity HAMAP MF_00051.

Sequence similarities

Belongs to the SHMT family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 415415Pyridoxal-phosphate-dependent serine hydroxymethyltransferase 2
PRO_0000113542

Regions

Region125 – 1273Substrate binding By similarity

Sites

Binding site351Pyridoxal phosphate By similarity
Binding site551Pyridoxal phosphate By similarity
Binding site571Substrate By similarity
Binding site641Substrate binding By similarity
Binding site651Pyridoxal phosphate By similarity
Binding site991Pyridoxal phosphate By similarity
Binding site1211Substrate By similarity
Binding site1751Pyridoxal phosphate By similarity
Binding site2031Pyridoxal phosphate By similarity
Binding site2281Pyridoxal phosphate By similarity
Binding site2351Pyridoxal phosphate By similarity
Binding site2601Pyridoxal phosphate; via amide nitrogen and carbonyl oxygen By similarity
Binding site3601Pyridoxal phosphate By similarity

Amino acid modifications

Modified residue2291N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7W400 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 45FB9109356A94EE

FASTA41544,763
        10         20         30         40         50         60 
MFNRNLTLDQ VDPDVWAAIQ KEDVRQEQHI ELIASENYAS PAVMQAQGTQ LTNKYAEGYP 

        70         80         90        100        110        120 
GKRYYGGCEY VDVVEQLAID RLKQIFGAEA ANVQPNSGSQ ANQGVYMAVL KPGDTVLGMS 

       130        140        150        160        170        180 
LAEGGHLTHG ASVNASGKLY NFVPYGLDAD EVLDYAQVER LTKEHKPKLI VAGASAYALH 

       190        200        210        220        230        240 
IDFERMARIA HDNGALFMVD IAHYAGLVAG GAYPNPVPHA DFVTSTTHKS LRGPRGGVIM 

       250        260        270        280        290        300 
MKAEVEKAVN SAIFPGIQGG PLMHVIAAKA VAFKEALSPE FQDYAQQVVK NAKVLADTLV 

       310        320        330        340        350        360 
KRGLRIVSGR TESHVMLVDL RPKGITGKEA EAVLGQAHIT VNKNAIPNDP EKPFVTSGIR 

       370        380        390        400        410 
LGTPAMTTRG FKEAEAELTA NLIADVLDNP RDEANIAAVR ARVNELTARL PVYGN

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX640435 Genomic DNA. Translation: CAE39158.1.
RefSeqNP_886027.1. NC_002928.3.

3D structure databases

ProteinModelPortalQ7W400.
SMRQ7W400. Positions 1-414.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1667986.
GenomeReviewsGene locus BPP3875 in contig BX470249_GR.
KEGGbpa:BPP3875.
NMPDRfig|257311.1.peg.3661.
PATRIC21151815. VBIBorPar43418_4066.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG301263.
OMAAHMTINK.
PhylomeDBQ7W400.
ProtClustDBPRK00011.

Enzyme and pathway databases

BioCycBPAR257311:BPP3875-MONOMER.

Family and domain databases

HAMAPMF_00051. SHMT.
[Tree]
InterProIPR015424. PyrdxlP-dep_Trfase_major_dom.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR001085. Ser_HO-MeTrfase.
IPR019798. Ser_HO-MeTrfase_PLP_BS.
[Graphical view]
Gene3DG3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
KOK00600.
PANTHERPTHR11680. Gly_HO-Metrfase. 1 hit.
PfamPF00464. SHMT. 1 hit.
[Graphical view]
PIRSFPIRSF000412. SHMT. 1 hit.
SUPFAMSSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
PROSITEPS00096. SHMT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLYA2_BORPA
AccessionPrimary (citable) accession number: Q7W400
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: October 1, 2003
Last modified: January 25, 2012
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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