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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei263ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:BPP3898
OrganismiBordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)
Taxonomic identifieri257311 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
Proteomesi
  • UP000001421 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001195191 – 481Glutamate--tRNA ligaseAdd BLAST481

Proteomic databases

PRIDEiQ7W3X9

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ7W3X9
SMRiQ7W3X9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi28 – 38"HIGH" regionUniRule annotationAdd BLAST11
Motifi260 – 264"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000252722
KOiK01885
OMAiAYYAFDT

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.8.70, 2 hits
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020752 aa-tRNA-synth_I_codon-bd_sub1
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q7W3X9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQSAERPRP YAFMTANATR PVRTRFAPSP TGFLHLGGAR TALFSWAFAR
60 70 80 90 100
HHQGVFVLRI EDTDVERSTP EAVQAILDSM DWLGMQPDEG PFYQMKRMDR
110 120 130 140 150
YAEVLAGMLE AGTAYHCYCS PEEVDAMREA ARAKGLKPRY DGTWRPEPGK
160 170 180 190 200
TLPPVPADRK PVIRFRNPID GATSWNDMVK GPISFDNGEL DDLIIARPDG
210 220 230 240 250
TPTYNFCVVV DDWDMGITHV LRGDDHVNNT PRQINILRAL GATLPEYGHV
260 270 280 290 300
PMILGPDGEK LSKRHGAVNV MEYDAQGYLP EAMINYLARL GWSHGDDELF
310 320 330 340 350
TREQLVEWFD TRHLSKSASQ WDPKKLNWVN AHYIKGMDDA ELAGRVAPRV
360 370 380 390 400
ERRGGKPQAA DLPAIMGLLK DRAETLEQLA EDAMLFCGEY QPAPAELAAQ
410 420 430 440 450
HLTETARAAL ADFAARARDT EWNRAAISAL IKAVLADRGL KMPQLGIPLR
460 470 480
VAVTGRAQTP AVDAVLELLG KETVLARLQA L
Length:481
Mass (Da):53,413
Last modified:October 1, 2003 - v1
Checksum:i6D8554F74E16DC7C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640435 Genomic DNA Translation: CAE39181.1
RefSeqiWP_010929301.1, NC_002928.3

Genome annotation databases

EnsemblBacteriaiCAE39181; CAE39181; BPP3898
KEGGibpa:BPP3898

Similar proteinsi

Entry informationi

Entry nameiSYE_BORPA
AccessioniPrimary (citable) accession number: Q7W3X9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: October 1, 2003
Last modified: May 23, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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