Reviewed, UniProtKB/Swiss-Prot Q7W396 (DSBC_BORPA)

Names and origin

Protein names

Recommended name:
    Probable thiol:disulfide interchange protein dsbC

Gene names

Name:	dsbC
Ordered Locus Names:	BPP4150

Organism

Bordetella parapertussis [Complete proteome] [HAMAP]

Taxonomic identifier

519 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length	279 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process By similarity.
Subcellular location	Periplasm By similarity.
Sequence similarities	Belongs to the thioredoxin family. DsbC subfamily.

Ontologies

Keywords
Cellular component	Periplasm
Domain	Redox-active center Signal
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro
Cellular component	periplasmic space Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 31	31	Potential
	Chain	32 – 279	248	Probable thiol:disulfide interchange protein dsbC		PRO_0000245644
Amino acid modifications
	Disulfide bond	174 ↔ 177		Redox-active By similarity
	Disulfide bond	213 ↔ 236		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7W396-1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 367CD6DC9DDCCDD1	FASTA	279	30,683
	10 20 30 40 50 60 MSGPPFSGAG MNFRITVWCA AAAVWSSGAL AQDGAGQAAP GTPDKVYSTT GTAPAKPGDK 70 80 90 100 110 120 VYSTRSAQAP DPQADAVKER FAQRFEGFDV TAVRRTPYGL FEVQIGTDLL YTDEKVTWVM 130 140 150 160 170 180 EGPLIDALTR RDVTRERQEK LSSVPFDELP LDLAVKQVKG DGSRVMAVFE DPNCGYCKQL 190 200 210 220 230 240 HRTLEDMDNI TVYTFLYPIL SPDSTTKVRD IWCASDPAKV WKDWMVRGQR PPTAECDAPV 250 260 270 EQWLALGRQL MVRGTPAIFF KSGGRVSGAL PRDELEARL

References

[1]

"Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica." Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S. , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J. Nat. Genet. 35:32-40(2003) [PubMed: 12910271] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 12822 / ATCC BAA-587 / NCTC 13253.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX640435 Genomic DNA. Translation: CAE39429.1.
RefSeq	NP_886283.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1665415.
GenomeReviews	Gene locus BPP4150 in contig BX470249_GR.
KEGG	bpa:BPP4150.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q7W396.
OMA	Q7W396. GLYEVKL.
Enzyme and pathway databases
BioCyc	BPAR257311:BPP4150-MON.
Family and domain databases
InterPro	IPR018950. dS-bond_isomerase_DsbC/G_N. IPR017937. Thioredoxin_CS. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
Pfam	PF10411. DsbC_N. 1 hit. [Graphical view]
PROSITE	PS00194. THIOREDOXIN_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DSBC_BORPA

Accession

Primary (citable) accession number: Q7W396

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2006
Last sequence update:	October 1, 2003
Last modified:	June 16, 2009
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)