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Q7W294

- MASZ_BORPA

UniProt

Q7W294 - MASZ_BORPA

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Protein

Malate synthase G

Gene

glcB

Organism
Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.UniRule annotation

Catalytic activityi

Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei118 – 1181Acetyl-CoA; via carbonyl oxygenUniRule annotation
Binding sitei275 – 2751Acetyl-CoAUniRule annotation
Binding sitei312 – 3121Acetyl-CoAUniRule annotation
Active sitei339 – 3391Proton acceptorUniRule annotation
Binding sitei339 – 3391GlyoxylateUniRule annotation
Metal bindingi428 – 4281MagnesiumUniRule annotation
Binding sitei428 – 4281GlyoxylateUniRule annotation
Metal bindingi456 – 4561MagnesiumUniRule annotation
Binding sitei537 – 5371Acetyl-CoA; via carbonyl oxygenUniRule annotation
Active sitei632 – 6321Proton donorUniRule annotation

GO - Molecular functioni

  1. malate synthase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-HAMAP
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciBPAR257311:BPP0096-MONOMER.
UniPathwayiUPA00703; UER00720.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate synthase GUniRule annotation (EC:2.3.3.9UniRule annotation)
Gene namesi
Name:glcBUniRule annotation
Ordered Locus Names:BPP0096
OrganismiBordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)
Taxonomic identifieri257311 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
ProteomesiUP000001421: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 725725Malate synthase GPRO_1000056894Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei618 – 6181Cysteine sulfenic acid (-SOH)UniRule annotation

Keywords - PTMi

Oxidation

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi257311.BPP0096.

Structurei

3D structure databases

ProteinModelPortaliQ7W294.
SMRiQ7W294. Positions 10-717.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni125 – 1262Acetyl-CoA bindingUniRule annotation
Regioni453 – 4564Glyoxylate bindingUniRule annotation

Sequence similaritiesi

Belongs to the malate synthase family. GlcB subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG2225.
HOGENOMiHOG000220740.
KOiK01638.
OMAiSQFIENE.
OrthoDBiEOG6HJ286.

Family and domain databases

Gene3Di2.170.170.11. 2 hits.
HAMAPiMF_00641. Malate_synth_G.
InterProiIPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view]
PfamiPF01274. Malate_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF51645. SSF51645. 1 hit.
TIGRFAMsiTIGR01345. malate_syn_G. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7W294-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTERIPHHGL QVAASLHRFI EDEALSGSGL APDEFWAGFA ALVRDLAPRN
60 70 80 90 100
RELLAERDRL QGEIDAWHRA HPGPVRDSAG YQALLERIGY LQPQPAQVTA
110 120 130 140 150
STRDVDSEIA SQAGPQLVVP VSNARYALNA ANARWGSLYD ALYGTDAIPP
160 170 180 190 200
VAGDDGKGYN PARGEAVIAR ARAFLDEAAP LAQGSHADAT AYAIEGGKLA
210 220 230 240 250
VTLGAGQRTG LRNPAQLAGY QGDASQPAAV LLANNGLHFE IQIDRQHQIG
260 270 280 290 300
ATDAAGVKDV LLEAALTTIM DCEDSVAAVD ADDKVLIYRN WLGLMKGDLS
310 320 330 340 350
ESVTKGGKTF TRRLNADRQY HKPDGGTLTL HGRSLMFVRN VGHLMTNPAI
360 370 380 390 400
LDEQGNEVPE GILDAVITSL AALPDRANRL NSRTGSIYIV KPKMHGPAEA
410 420 430 440 450
AFANELFDRV EDLLKLPRHT IKMGIMDEER RTSVNLKACI AAAAARVAFI
460 470 480 490 500
NTGFLDRTGD EMHTGMEAGP MLRKGDMKSS AWITAYERNN VLVGLDCGLR
510 520 530 540 550
GRAQIGKGMW AMPDMMAAML EQKIGHPKAG ANTAWVPSPT AATLHAMHYH
560 570 580 590 600
QVDVAAVQQA LEQTRYDSVR DELLAGLLTV PVGDPAAWSA DDIQRELDNN
610 620 630 640 650
AQGILGYVVR WIDQGVGCSK VPDINNVGLM EDRATLRISS QHIANWLRHG
660 670 680 690 700
IVDRAQVNAT FERMAKVVDQ QNAGDPNYLP MAGHFDTSFA YRAACALVFE
710 720
GLTQPNGYTE PLLHEYRQAF KAAQR
Length:725
Mass (Da):78,547
Last modified:October 1, 2003 - v1
Checksum:i56CFA5BAAD16127C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640423 Genomic DNA. Translation: CAE39837.1.
RefSeqiNP_882459.1. NC_002928.3.

Genome annotation databases

EnsemblBacteriaiCAE39837; CAE39837; BPP0096.
GeneIDi1668785.
KEGGibpa:BPP0096.
PATRICi21143751. VBIBorPar43418_0104.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640423 Genomic DNA. Translation: CAE39837.1 .
RefSeqi NP_882459.1. NC_002928.3.

3D structure databases

ProteinModelPortali Q7W294.
SMRi Q7W294. Positions 10-717.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257311.BPP0096.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE39837 ; CAE39837 ; BPP0096 .
GeneIDi 1668785.
KEGGi bpa:BPP0096.
PATRICi 21143751. VBIBorPar43418_0104.

Phylogenomic databases

eggNOGi COG2225.
HOGENOMi HOG000220740.
KOi K01638.
OMAi SQFIENE.
OrthoDBi EOG6HJ286.

Enzyme and pathway databases

UniPathwayi UPA00703 ; UER00720 .
BioCyci BPAR257311:BPP0096-MONOMER.

Family and domain databases

Gene3Di 2.170.170.11. 2 hits.
HAMAPi MF_00641. Malate_synth_G.
InterProi IPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view ]
Pfami PF01274. Malate_synthase. 1 hit.
[Graphical view ]
SUPFAMi SSF51645. SSF51645. 1 hit.
TIGRFAMsi TIGR01345. malate_syn_G. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica."
    Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S.
    , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J.
    Nat. Genet. 35:32-40(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 12822 / ATCC BAA-587 / NCTC 13253.

Entry informationi

Entry nameiMASZ_BORPA
AccessioniPrimary (citable) accession number: Q7W294
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 1, 2003
Last modified: November 26, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3