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Q7W1T9 (ASPD1_BORPA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable L-aspartate dehydrogenase 1

EC=1.4.1.21
Gene names
Name:nadX1
Ordered Locus Names:BPP0257
OrganismBordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253) [Complete proteome] [HAMAP]
Taxonomic identifier257311 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella

Protein attributes

Sequence length258 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate By similarity. HAMAP-Rule MF_01265

Catalytic activity

L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H. HAMAP-Rule MF_01265

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (dehydrogenase route): step 1/1. HAMAP-Rule MF_01265

Miscellaneous

The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia By similarity.

Sequence similarities

Belongs to the L-aspartate dehydrogenase family.

Sequence caution

The sequence CAE39998.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 258258Probable L-aspartate dehydrogenase 1 HAMAP-Rule MF_01265
PRO_0000144883

Sites

Active site2111 By similarity
Binding site1211NAD; via amide nitrogen By similarity
Binding site1811NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7W1T9 [UniParc].

Last modified August 16, 2005. Version 2.
Checksum: 185F7E1B0C222E44

FASTA25826,302
        10         20         30         40         50         60 
MNTPLRVGIV GCGVLANAMA GHLARQPRPV EIVGCLVRDP GRARGALPCH GSWEALLAQR 

        70         80         90        100        110        120 
PEVVVECAGQ AALAQYAQAI LAAGVDLVPA SVGALADDAL RGALLEAAAA AGARIRIPSG 

       130        140        150        160        170        180 
AMVGIDGLAA ARHVGVAEVL YRGTMPPVAL QRYVSGPLPE RGLAFAGSAR EAVARFPKNA 

       190        200        210        220        230        240 
NLTGTIALAG IGFDRTRVEM LIDPDATANV HELLARGEFG DFHARVSGLR ISESSPSSRI 

       250 
VAGSLAQAAL GSGFLALS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX640423 Genomic DNA. Translation: CAE39998.1. Different initiation.
RefSeqNP_882616.1. NC_002928.3.

3D structure databases

ProteinModelPortalQ7W1T9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING257311.BPP0257.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE39998; CAE39998; BPP0257.
GeneID1668964.
KEGGbpa:BPP0257.
PATRIC21144080. VBIBorPar43418_0268.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1712.
HOGENOMHOG000206326.
KOK06989.
OrthoDBEOG6ND0JC.

Enzyme and pathway databases

BioCycBPAR257311:BPP0257-MONOMER.
UniPathwayUPA00253; UER00456.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_01265. NadX.
InterProIPR005106. Asp/hSer_DH_NAD-bd.
IPR002811. Asp_DH.
IPR011182. Asp_DH_NAD_syn.
IPR020626. Asp_DH_NAD_syn_prok.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF01958. DUF108. 1 hit.
PF03447. NAD_binding_3. 1 hit.
[Graphical view]
PIRSFPIRSF005227. Asp_dh_NAD_syn. 1 hit.
ProtoNetSearch...

Entry information

Entry nameASPD1_BORPA
AccessionPrimary (citable) accession number: Q7W1T9
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2005
Last modified: May 14, 2014
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways