Reviewed, UniProtKB/Swiss-Prot Q7W1I6 (GLYA1_BORPA)

Names and origin

Protein names

Recommended name:
    Serine hydroxymethyltransferase 1
      Short name=Serine methylase 1
      Short name=SHMT 1
    EC=2.1.2.1

Gene names

Name:	glyA1
Ordered Locus Names:	BPP0701

Organism

Bordetella parapertussis [Complete proteome] [HAMAP]

Taxonomic identifier

519 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length	430 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Interconversion of serine and glycine. HAMAP MF_00051
Catalytic activity	5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. HAMAP MF_00051
Cofactor	Pyridoxal phosphate By similarity.
Pathway	One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_00051
Subunit structure	Homotetramer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the SHMT family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Cellular component	Cytoplasm
Ligand	Pyridoxal phosphate
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	L-serine metabolic process Inferred from electronic annotation. Source: InterPro glycine metabolic process Inferred from electronic annotation. Source: InterPro one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glycine hydroxymethyltransferase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 430	430	Serine hydroxymethyltransferase 1 HAMAP MF_00051		PRO_0000113541
Amino acid modifications
	Modified residue	241	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7W1I6-1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 959CAD29A1F23B17	FASTA	430	45,238
	10 20 30 40 50 60 MNDLLPAAAA PAGARALPLR HADPEIWRAV DAERQRQMHS IELIASENFV SQAVLDAQGS 70 80 90 100 110 120 VMTNKYAEGY PGRRYYGGCR HVDVAERAAI ERARRLFGCE YANVQPHSGS QANQAVYLAL 130 140 150 160 170 180 LAPGDRILGL DLKAGGHLTH GARVNLSGKW FEALSYGVDP VSHRIDMDEV ERTARRERPR 190 200 210 220 230 240 LIIAGGSAYA RVPDFARFRA IADATGALFV ADMAHYAGLV AGGAFPSPVP FAHVTTTTTH 250 260 270 280 290 300 KTLRGPRGGM ILTDDADIAR RIDAAVFPGL QGGPLMHVIA AKAVALGEAL QPGFRAYARA 310 320 330 340 350 360 VIDNARALCA RLAEGGLSIV SGGTDCHLGV VDLRPWGLAG NAAERALEEA GITVNKNAVP 370 380 390 400 410 420 GDAASPAVTS GIRVGSAACT SRGMGPAEFR QIGDLVLAVL GGLRDGGQAG GRDAVPARAA 430 ELSRRFPLPY

References

[1]

"Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica." Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S. , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J. Nat. Genet. 35:32-40(2003) [PubMed: 12910271] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 12822 / ATCC BAA-587 / NCTC 13253.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX640425 Genomic DNA. Translation: CAE40110.1.
RefSeq	NP_883041.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1668395.
GenomeReviews	Gene locus BPP0701 in contig BX470249_GR.
KEGG	bpa:BPP0701.
NMPDR	fig|257311.1.peg.675.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q7W1I6.
OMA	TVCEKIN.
Enzyme and pathway databases
BioCyc	BPAR257311:BPP0701-MON.
BRENDA	2.1.2.1. 263123.
Family and domain databases
HAMAP	MF_00051. [Tree]
InterPro	IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR001085. Ser_HO-MeTrfase. IPR019798. Ser_HO-MeTrfase_PLP_BS. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
PANTHER	PTHR11680. Gly_HO-Metrfase. 1 hit.
Pfam	PF00464. SHMT. 1 hit. [Graphical view]
PIRSF	PIRSF000412. SHMT. 1 hit.
PROSITE	PS00096. SHMT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLYA1_BORPA

Accession

Primary (citable) accession number: Q7W1I6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
Last sequence update:	October 1, 2003
Last modified:	November 3, 2009
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)