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Q7W1C4

- GCSP_BORPA

UniProt

Q7W1C4 - GCSP_BORPA

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Protein

Glycine dehydrogenase (decarboxylating)

Gene
gcvP, BPP0771
Organism
Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciBPAR257311:BPP0771-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:BPP0771
OrganismiBordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)
Taxonomic identifieri257311 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
ProteomesiUP000001421: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 954954Glycine dehydrogenase (decarboxylating)UniRule annotationPRO_0000166905Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei701 – 7011N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi257311.BPP0771.

Structurei

3D structure databases

ProteinModelPortaliQ7W1C4.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7W1C4-1 [UniParc]FASTAAdd to Basket

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MSRAPDTHSD FIPRHIGPSD EDQATMLAAI GAASLDALID EVVPPRIRSR    50
APLALPAARS ETDVLQDLKR MAARNQIYRN YIGQGYYGTH TPNVVLRNVL 100
ENPAWYTAYT PYQPEISQGR LEALLNYQTM VADLTGLDIS NASLLDEGTA 150
AAEAMTLARR GSRSSSPVFF VSQHCHPQTL EVVRTRAEGL GIELVIGDES 200
RGLPECFGVL LQYPHSLGGV ADYRELAQAA HAQGAVVACV TDLLALALIE 250
PPGQWGADIA VGSAQRFGVP FGFGGPHAGF MACRDAYKRN MPGRLVGVSK 300
DAQGNPALRL ALQTREQHIR REKATSNICT AQVLLAVMAG LYAVWHGPRG 350
VRRIAERVQS LTGALRAALA GLGVKVANDT WFDTLLLETG VATPAILAAA 400
DCARTNLRQV DGARLAVSLD ETVTLADLQA LVNVFAAGLG KDEVALPAPQ 450
ASLDGIPAAV RRQGPILSHP VFSSVQSETD MLRYLRKLAD KDLALDRTMI 500
PLGSCTMKLN ATAEMIPITW PEFALIHPFA PASQTPGYRE LIDGLSAQLC 550
EITGYDGISL QPNSGAQGEY AGLLAIRAYH QANGQPQRNV CLIPASAHGT 600
NPASAQLAGM DVVVVASDAN GNVDLADLRA RIAQVGERLA ALMITYPSTH 650
GVFEEAVTEI CDAVHEAGGQ VYLDGANMNA MVGVAQPGKF GSDVSHLNLH 700
KTFCIPHGGG GPGVGPVAVR AHLAPYLPGV LDAQGRLDPE AKVGPVSAAP 750
YGSAGILPIP YVYIALMGAE GLRRATEVAI LNANYIAARL RDHYPVLYAG 800
RNGRVAHECI LDVRPLKETS GISAEDIAKR LMDYGFHAPT MSFPVAGTLM 850
VEPTESEGLA ELERFIEAMI AIRAEIAQIE SGERDRDDNV LRNAPHTAQM 900
LLAEEWHHDY PRQQAAYPVA SLRENKYWPP VARVDNAYGD RNLVCACLPV 950
EAYA 954
Length:954
Mass (Da):102,109
Last modified:October 1, 2003 - v1
Checksum:i7758190B5CDB465B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX640425 Genomic DNA. Translation: CAE40180.1.
RefSeqiNP_883104.1. NC_002928.3.
WP_010927674.1. NC_002928.3.

Genome annotation databases

EnsemblBacteriaiCAE40180; CAE40180; BPP0771.
GeneIDi1668533.
KEGGibpa:BPP0771.
PATRICi21145154. VBIBorPar43418_0796.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX640425 Genomic DNA. Translation: CAE40180.1 .
RefSeqi NP_883104.1. NC_002928.3.
WP_010927674.1. NC_002928.3.

3D structure databases

ProteinModelPortali Q7W1C4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257311.BPP0771.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE40180 ; CAE40180 ; BPP0771 .
GeneIDi 1668533.
KEGGi bpa:BPP0771.
PATRICi 21145154. VBIBorPar43418_0796.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci BPAR257311:BPP0771-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica."
    Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S.
    , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J.
    Nat. Genet. 35:32-40(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 12822 / ATCC BAA-587 / NCTC 13253.

Entry informationi

Entry nameiGCSP_BORPA
AccessioniPrimary (citable) accession number: Q7W1C4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: October 1, 2003
Last modified: September 3, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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