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Q7W1C4

- GCSP_BORPA

UniProt

Q7W1C4 - GCSP_BORPA

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciBPAR257311:BPP0771-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:BPP0771
    OrganismiBordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)
    Taxonomic identifieri257311 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
    ProteomesiUP000001421: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 954954Glycine dehydrogenase (decarboxylating)PRO_0000166905Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei701 – 7011N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi257311.BPP0771.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7W1C4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiFDSRPYS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q7W1C4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRAPDTHSD FIPRHIGPSD EDQATMLAAI GAASLDALID EVVPPRIRSR    50
    APLALPAARS ETDVLQDLKR MAARNQIYRN YIGQGYYGTH TPNVVLRNVL 100
    ENPAWYTAYT PYQPEISQGR LEALLNYQTM VADLTGLDIS NASLLDEGTA 150
    AAEAMTLARR GSRSSSPVFF VSQHCHPQTL EVVRTRAEGL GIELVIGDES 200
    RGLPECFGVL LQYPHSLGGV ADYRELAQAA HAQGAVVACV TDLLALALIE 250
    PPGQWGADIA VGSAQRFGVP FGFGGPHAGF MACRDAYKRN MPGRLVGVSK 300
    DAQGNPALRL ALQTREQHIR REKATSNICT AQVLLAVMAG LYAVWHGPRG 350
    VRRIAERVQS LTGALRAALA GLGVKVANDT WFDTLLLETG VATPAILAAA 400
    DCARTNLRQV DGARLAVSLD ETVTLADLQA LVNVFAAGLG KDEVALPAPQ 450
    ASLDGIPAAV RRQGPILSHP VFSSVQSETD MLRYLRKLAD KDLALDRTMI 500
    PLGSCTMKLN ATAEMIPITW PEFALIHPFA PASQTPGYRE LIDGLSAQLC 550
    EITGYDGISL QPNSGAQGEY AGLLAIRAYH QANGQPQRNV CLIPASAHGT 600
    NPASAQLAGM DVVVVASDAN GNVDLADLRA RIAQVGERLA ALMITYPSTH 650
    GVFEEAVTEI CDAVHEAGGQ VYLDGANMNA MVGVAQPGKF GSDVSHLNLH 700
    KTFCIPHGGG GPGVGPVAVR AHLAPYLPGV LDAQGRLDPE AKVGPVSAAP 750
    YGSAGILPIP YVYIALMGAE GLRRATEVAI LNANYIAARL RDHYPVLYAG 800
    RNGRVAHECI LDVRPLKETS GISAEDIAKR LMDYGFHAPT MSFPVAGTLM 850
    VEPTESEGLA ELERFIEAMI AIRAEIAQIE SGERDRDDNV LRNAPHTAQM 900
    LLAEEWHHDY PRQQAAYPVA SLRENKYWPP VARVDNAYGD RNLVCACLPV 950
    EAYA 954
    Length:954
    Mass (Da):102,109
    Last modified:October 1, 2003 - v1
    Checksum:i7758190B5CDB465B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX640425 Genomic DNA. Translation: CAE40180.1.
    RefSeqiNP_883104.1. NC_002928.3.
    WP_010927674.1. NC_002928.3.

    Genome annotation databases

    EnsemblBacteriaiCAE40180; CAE40180; BPP0771.
    GeneIDi1668533.
    KEGGibpa:BPP0771.
    PATRICi21145154. VBIBorPar43418_0796.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX640425 Genomic DNA. Translation: CAE40180.1 .
    RefSeqi NP_883104.1. NC_002928.3.
    WP_010927674.1. NC_002928.3.

    3D structure databases

    ProteinModelPortali Q7W1C4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 257311.BPP0771.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE40180 ; CAE40180 ; BPP0771 .
    GeneIDi 1668533.
    KEGGi bpa:BPP0771.
    PATRICi 21145154. VBIBorPar43418_0796.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi FDSRPYS.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci BPAR257311:BPP0771-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica."
      Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S.
      , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J.
      Nat. Genet. 35:32-40(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 12822 / ATCC BAA-587 / NCTC 13253.

    Entry informationi

    Entry nameiGCSP_BORPA
    AccessioniPrimary (citable) accession number: Q7W1C4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 2, 2004
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3