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Protein

DNA-directed RNA polymerase subunit beta

Gene

rpoB

Organism
Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Transcription

Enzyme and pathway databases

BioCyciBPER257313:BP0015-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit betaUniRule annotation (EC:2.7.7.6UniRule annotation)
Short name:
RNAP subunit betaUniRule annotation
Alternative name(s):
RNA polymerase subunit betaUniRule annotation
Transcriptase subunit betaUniRule annotation
Gene namesi
Name:rpoBUniRule annotation
Ordered Locus Names:BP0015
OrganismiBordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Taxonomic identifieri257313 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
Proteomesi
  • UP000002676 Componenti: Chromosome

Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13701370DNA-directed RNA polymerase subunit betaPRO_0000047867Add
BLAST

Proteomic databases

PRIDEiQ7W0R9.

Interactioni

Subunit structurei

The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.UniRule annotation

Protein-protein interaction databases

STRINGi257313.BP0015.

Structurei

3D structure databases

ProteinModelPortaliQ7W0R9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNA polymerase beta chain family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108IIJ. Bacteria.
COG0085. LUCA.
HOGENOMiHOG000218612.
KOiK03043.
OMAiWWMFAVE.

Family and domain databases

CDDicd00653. RNA_pol_B_RPB2. 1 hit.
Gene3Di2.30.150.10. 1 hit.
2.40.270.10. 2 hits.
2.40.50.150. 2 hits.
3.90.1110.10. 2 hits.
HAMAPiMF_01321. RNApol_bact_RpoB. 1 hit.
InterProiIPR019462. DNA-dir_RNA_pol_bsu_external_1.
IPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR010243. RNA_pol_bsu_bac.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view]
PANTHERiPTHR20856. PTHR20856. 5 hits.
PfamiPF04563. RNA_pol_Rpb2_1. 1 hit.
PF04561. RNA_pol_Rpb2_2. 2 hits.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF10385. RNA_pol_Rpb2_45. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02013. rpoB. 1 hit.
PROSITEiPS01166. RNA_POL_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7W0R9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYSYTEKKR IRKSFAKRED VQNVPFLLAT QLQSYLTFLQ ADTATSDRVN
60 70 80 90 100
EGLQAAFSSI FPIVSHNGMA RLEFVSYALG EPVFDVKECQ QRGLTYASPL
110 120 130 140 150
RAKVRLVLLD REVSKPTIKE VKEQEVYMGE IPLMTGTGSF VINGTERVIV
160 170 180 190 200
SQLHRSPGVF FEHDRGKTHS SGKLLFSARV IPYRGSWLDF EFDPKDVLFF
210 220 230 240 250
RVDRRRKMPV TILLKAIGMT PESILAHFFD FDNFELKSEG GMMEFVAERW
260 270 280 290 300
KGEMARFDIA DRDGKVIVEK DKRINAKHLR DLAAGGIQRV SVPEDFLYGR
310 320 330 340 350
VLAKNIVDPD TGEVVAHAND EITESVLNAM RAANVRDIQT LYTNDLDRGP
360 370 380 390 400
YISQTLRADE TADQMAARVA IYRMMRPGEP PTEEAVEALF QRLFYSEETY
410 420 430 440 450
DLSRVGRMKV NSRLGRGDDS TGPMTLTNED ILETIKVLVE LRNGRGQIDD
460 470 480 490 500
IDHLGNRRVR CVGELAENQF RAGLVRVERA VKERLGQAET ENLMPHDLIN
510 520 530 540 550
SKPISAAIKE FFGSSQLSQF MDQTNPLSEI THKRRVSALG PGGLTRERAG
560 570 580 590 600
FEVRDVHPTH YGRVCPIETP EGPNIGLINS MALYARLNEY GFLETPYRKI
610 620 630 640 650
IDGKVSDQID YLSAIEESHY VIAQANAALD DEGRFVDDLV ACREAGETML
660 670 680 690 700
TAPGNVHYMD VAPSQIVSVA ASLIPFLEHD DANRALMGAN MQRQAVPCLR
710 720 730 740 750
PEKPLVGTGV ERTVAVDSGT TVQALRGGVV DHVDADRVVI RVNDEENVAG
760 770 780 790 800
EVGVDIYNLI KYTRSNQNTN INQRPIVARG DKVAKGDVLA DGASTDLGEL
810 820 830 840 850
ALGQNMLIAF MPWNGYNFED SILISERVVA DDRYTSIHIE ELTVVARDTK
860 870 880 890 900
LGPEEITRDI SNLAETQLNR LDDSGIVYIG AEVSADDVLV GKVTPKGETQ
910 920 930 940 950
LTPEEKLLRA IFGEKASDVK DTSLRVPSGM TGTVIDVQVF TREGIVRDKR
960 970 980 990 1000
AQSIIDDELR RYRQDLNDQL RIVENDQFDR IEKMLVGKTV NGGPRKLAKG
1010 1020 1030 1040 1050
ATLTKAYLAD LDRWQWFDIR LADEQHAVVL EQAKESLEQK RHQFDLAFEE
1060 1070 1080 1090 1100
KRKKLTQGDE LPPGVLKMIK VYLAVKRRLQ PGDKMAGRHG NKGVVSRITP
1110 1120 1130 1140 1150
VEDMPHMADG TPADIVLNPL GVPSRMNVGQ VLEVHLGWAA KGVGYRIADM
1160 1170 1180 1190 1200
LRDERTAQAK SVRGYLEKVY NTTGSSAHID SLTDEEVLEL ANNLKKGVPF
1210 1220 1230 1240 1250
ATPVFDGATE EEIGKMLELA YPDDVAARMR LTASRSQAWL YDGRTGEQFE
1260 1270 1280 1290 1300
RPVTIGYMHY LKLHHLVDDK MHARSTGPYS LVTQQPLGGK AQFGGQRFGE
1310 1320 1330 1340 1350
MEVWALEAYG ASYTLQEMLT VKSDDITGRT KVYENIVKGD HVIDAGMPES
1360 1370
FNVLVKEIRS LALDMDLERN
Length:1,370
Mass (Da):153,153
Last modified:October 1, 2003 - v1
Checksum:i3EBFF16C385E8D75
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640411 Genomic DNA. Translation: CAE40394.1.
RefSeqiNP_878932.1. NC_002929.2.
WP_010929573.1. NC_002929.2.

Genome annotation databases

EnsemblBacteriaiCAE40394; CAE40394; BP0015.
GeneIDi2664688.
KEGGibpe:BP0015.
PATRICi21153014. VBIBorPer7866_0015.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640411 Genomic DNA. Translation: CAE40394.1.
RefSeqiNP_878932.1. NC_002929.2.
WP_010929573.1. NC_002929.2.

3D structure databases

ProteinModelPortaliQ7W0R9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi257313.BP0015.

Proteomic databases

PRIDEiQ7W0R9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAE40394; CAE40394; BP0015.
GeneIDi2664688.
KEGGibpe:BP0015.
PATRICi21153014. VBIBorPer7866_0015.

Phylogenomic databases

eggNOGiENOG4108IIJ. Bacteria.
COG0085. LUCA.
HOGENOMiHOG000218612.
KOiK03043.
OMAiWWMFAVE.

Enzyme and pathway databases

BioCyciBPER257313:BP0015-MONOMER.

Family and domain databases

CDDicd00653. RNA_pol_B_RPB2. 1 hit.
Gene3Di2.30.150.10. 1 hit.
2.40.270.10. 2 hits.
2.40.50.150. 2 hits.
3.90.1110.10. 2 hits.
HAMAPiMF_01321. RNApol_bact_RpoB. 1 hit.
InterProiIPR019462. DNA-dir_RNA_pol_bsu_external_1.
IPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR010243. RNA_pol_bsu_bac.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view]
PANTHERiPTHR20856. PTHR20856. 5 hits.
PfamiPF04563. RNA_pol_Rpb2_1. 1 hit.
PF04561. RNA_pol_Rpb2_2. 2 hits.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF10385. RNA_pol_Rpb2_45. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02013. rpoB. 1 hit.
PROSITEiPS01166. RNA_POL_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRPOB_BORPE
AccessioniPrimary (citable) accession number: Q7W0R9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: October 1, 2003
Last modified: September 7, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.