Reviewed, UniProtKB/Swiss-Prot Q7W0K2 (DSBA_BORPE)

Names and origin

Protein names

Recommended name:
    Thiol:disulfide interchange protein dsbA

Gene names

Name:	dsbA
Ordered Locus Names:	BP0113

Organism

Bordetella pertussis [Complete proteome] [HAMAP]

Taxonomic identifier

520 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length	209 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Involved in disulfide-bond formation. Acts by transferring its disulfide bond to other proteins By similarity. Required for periplasmic assembly of the pertussis toxin (PTX).
Subcellular location	Periplasm By similarity.
Sequence similarities	Belongs to the thioredoxin family. DsbA subfamily.

Ontologies

Keywords
Cellular component	Periplasm
Domain	Redox-active center Signal
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro
Cellular component	outer membrane-bounded periplasmic space Inferred from electronic annotation. Source: InterPro
Molecular function	protein disulfide oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 27	27	Potential
	Chain	28 – 209	182	Thiol:disulfide interchange protein dsbA		PRO_0000245632
Amino acid modifications
	Disulfide bond	58 ↔ 61		Redox-active By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7W0K2-1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 9891E9CD35C39E22	FASTA	209	22,784
	10 20 30 40 50 60 MQSTTFTRLL AAAALGATTL FAPATQAQGA QQYVNINPPM PSDTPGKIEV LEFFAYTCPH 70 80 90 100 110 120 CAAIEPMVED WAKTAPQDVV LKQVPIAFNA GMKPLQQLYY TLQALERPDL HPKVFTAIHT 130 140 150 160 170 180 ERKRLFDKKA MGEWAASQGV DRAKFDSVFD SFSVQTQVQH ASQLAEAAHI DGTPAFAVGG 190 200 RYMTSPVLAG NDYAGALKVV DQLIVQSRK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica." Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S. , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J. Nat. Genet. 35:32-40(2003) [PubMed: 12910271] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tohama I / ATCC BAA-589 / NCTC 13251.
[2]	"DsbA and DsbC are required for secretion of pertussis toxin by Bordetella pertussis." Stenson T.H., Weiss A.A. Infect. Immun. 70:2297-2303(2002) [PubMed: 11953363] [Abstract] Cited for: FUNCTION IN PERTUSSIS TOXIN SECRETION. Strain: Tohama I / BP338.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX640411 Genomic DNA. Translation: CAE40493.1.
RefSeq	NP_879015.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2667558.
GenomeReviews	Gene locus BP0113 in contig BX470248_GR.
KEGG	bpe:BP0113.
NMPDR	fig|257313.1.peg.95.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q7W0K2.
OMA	Q7W0K2. VANSHIF.
Enzyme and pathway databases
BioCyc	BPER257313:BP0113-MON.
Family and domain databases
InterPro	IPR001853. OxRdtase_DSBA. IPR017936. Thioredoxin-like. IPR017937. Thioredoxin_CS. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
Pfam	PF01323. DSBA. 1 hit. [Graphical view]
PROSITE	PS00194. THIOREDOXIN_1. 1 hit. PS51352. THIOREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DSBA_BORPE

Accession

Primary (citable) accession number: Q7W0K2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2006
Last sequence update:	October 1, 2003
Last modified:	June 16, 2009
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)