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Q7W0E3

- GCSP_BORPE

UniProt

Q7W0E3 - GCSP_BORPE

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciBPER257313:BP0197-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:BP0197
    OrganismiBordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
    Taxonomic identifieri257313 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
    ProteomesiUP000002676: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 954954Glycine dehydrogenase (decarboxylating)PRO_0000166906Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei701 – 7011N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi257313.BP0197.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7W0E3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiTAYLTHP.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q7W0E3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRAPDTHSD FIPRHIGPSD EDQATMLVAI GAASLDALID EVVPPRIRSR    50
    APLALPAARS ETDVLQDLKR IAARNQIYRN YIGQGYYGTH TPNVVLRNVL 100
    ENPAWYTAYT PYQPEISQGR LEALLNYQTM VADLTGLDIS NASLLDEGTA 150
    AAEAMTLARR GSRSSSPVFF VSQHCHPQTL EVVRTRAEGL GIELVIGDES 200
    RGLPECFGVL LQYPHSLGGV ADYRELAQAA HAQGAVVACV TDLLALALIE 250
    PPGQWGADIA VGSAQRFGVP FGFGGPHAGF MACRDAYKRN MPGRLVGVSK 300
    DAQGNPALRL ALQTREQHIR REKATSNICT AQVLLAVMAG LYAVWHGPRG 350
    VRRIAERVQS LTGALRAALA GLGVKVANDT WFDTLSLETG AATPAILAAA 400
    DCARINLRQV DGARLAVSLD ETVTLADLQA LVNVFAAGLG KDEVALAPPQ 450
    ASLDGIPAAV RRQGPILSHP VFSSVQSETD MLRYLRKLAD KDLALDRTMI 500
    PLGSCTMKLN ATAEMIPITW PEFALIHPFA PASQTPGYRE LIEGLSAQLC 550
    EITGYDGISL QPNSGAQGEY AGLLAIRAYH QANGQPQRNV CLIPASAHGT 600
    NPASAQLAGM DVVVVASDAN GNVDLADLRA RIAQVGERLA ALMITYPSTH 650
    GVFEEAVTEI CDAVHEAGGQ VYLDGANMNA MVGVAQPGKF GSDVSHLNLH 700
    KTFCIPHGGG GPGVGPVAVR AHLAPYLPGV LDARGRLDPE AKVGPVSAAP 750
    YGSAGILPIP YVYIALMGAE GLRRATEVAI LNANYIATRL RGHYPVLYAG 800
    RNGRVAHECI LDVRPLKETS GISAEDIAKR LMDYGFHAPT MSFPVAGTLM 850
    VEPTESEGLA ELERFIEAMI AIRAEIAQVE SGERDRDDNV LRNAPHTAQM 900
    LLAEEWHHDY PRQQAAYPVA SLRENKYWPP VARVDNAYGD RNLVCACLPV 950
    EAYA 954
    Length:954
    Mass (Da):102,077
    Last modified:October 1, 2003 - v1
    Checksum:i2DCD14ECA567D5BD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX640411 Genomic DNA. Translation: CAE40576.1.
    RefSeqiNP_879086.1. NC_002929.2.

    Genome annotation databases

    EnsemblBacteriaiCAE40576; CAE40576; BP0197.
    GeneIDi2664002.
    KEGGibpe:BP0197.
    PATRICi21153404. VBIBorPer7866_0209.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX640411 Genomic DNA. Translation: CAE40576.1 .
    RefSeqi NP_879086.1. NC_002929.2.

    3D structure databases

    ProteinModelPortali Q7W0E3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 257313.BP0197.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE40576 ; CAE40576 ; BP0197 .
    GeneIDi 2664002.
    KEGGi bpe:BP0197.
    PATRICi 21153404. VBIBorPer7866_0209.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi TAYLTHP.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci BPER257313:BP0197-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica."
      Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S.
      , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J.
      Nat. Genet. 35:32-40(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tohama I / ATCC BAA-589 / NCTC 13251.

    Entry informationi

    Entry nameiGCSP_BORPE
    AccessioniPrimary (citable) accession number: Q7W0E3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 2, 2004
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3