Reviewed, UniProtKB/Swiss-Prot Q7VZG1 (KCY_BORPE)

Names and origin

Protein names

Recommended name:
    Cytidylate kinase
      Short name=CK
    EC=2.7.4.14
Alternative name(s):
    Cytidine monophosphate kinase
      Short name=CMP kinase

Gene names

Name:	cmk
Ordered Locus Names:	BP0949

Organism

Bordetella pertussis [Complete proteome] [HAMAP]

Taxonomic identifier

520 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length	223 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + (d)CMP = ADP + (d)CDP. HAMAP MF_00238
Subcellular location	Cytoplasm By similarity HAMAP MF_00238.
Sequence similarities	Belongs to the cytidylate kinase family. Type 1 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pyrimidine nucleotide metabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP cytidylate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 223	223	Cytidylate kinase HAMAP MF_00238		PRO_0000131889
Regions
	Nucleotide binding	17 – 25	9	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7VZG1-1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: BAF1E2E2FA5EFD0A	FASTA	223	23,903
	10 20 30 40 50 60 MAIFASAGAA PVITIDGPTA SGKGTIAHRV AKQLGWDVLD SGALYRLTAL AALRRGLPAT 70 80 90 100 110 120 DEPAVAAVAQ ALDVRFDGPH VYLEGRDAGH EIRQEEVGNY ASRIAAYPGV RQALLERQRA 130 140 150 160 170 180 FRQPPGLVAD GRDMGAVVFP DASLKIFLVA DVEARAQRRC KQLIEKGISA NLDDLLRDMR 190 200 210 220 ERDARDTQRA VAPLAPAADA HVLDSSGLTI EQTVQAVLDF WCA

References

[1]

"Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica." Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S. , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J. Nat. Genet. 35:32-40(2003) [PubMed: 12910271] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tohama I / ATCC BAA-589 / NCTC 13251.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX640413 Genomic DNA. Translation: CAE41251.1.
RefSeq	NP_879750.1.
3D structure databases
SMR	Q7VZG1. Positions 11-221.
ModBase	Search...
Genome annotation databases
GeneID	2664293.
KEGG	bpe:BP0949.
NMPDR	fig|257313.1.peg.829.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG354377.
OMA	DTGLLYR.
PhylomeDB	Q7VZG1.
Enzyme and pathway databases
BioCyc	BPER257313:BP0949-MONOMER.
BRENDA	2.7.4.14. 21511.
Family and domain databases
HAMAP	MF_00238. Cytidyl_kinase_type1. [Tree]
InterPro	IPR003136. Cytidylate_kin. IPR011994. Cytidylate_kinase_dom. [Graphical view]
PANTHER	PTHR21299:SF2. Cytidylate_kin. 1 hit.
Pfam	PF02224. Cytidylate_kin. 1 hit. [Graphical view]
TIGRFAMs	TIGR00017. cmk. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KCY_BORPE

Accession

Primary (citable) accession number: Q7VZG1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 15, 2005
Last sequence update:	October 1, 2003
Last modified:	February 9, 2010
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)