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Protein

Probable chorismate pyruvate-lyase

Gene

ubiC

Organism
Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway.UniRule annotation

Catalytic activityi

Chorismate = 4-hydroxybenzoate + pyruvate.UniRule annotation

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei74 – 741SubstrateUniRule annotation
Binding sitei112 – 1121Substrate; via amide nitrogenUniRule annotation
Binding sitei173 – 1731SubstrateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Ubiquinone biosynthesis

Keywords - Ligandi

Pyruvate

Enzyme and pathway databases

BioCyciBPER257313:BP0981-MONOMER.
UniPathwayiUPA00232.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable chorismate pyruvate-lyaseUniRule annotation (EC:4.1.3.40UniRule annotation)
Short name:
CLUniRule annotation
Short name:
CPLUniRule annotation
Gene namesi
Name:ubiCUniRule annotation
Ordered Locus Names:BP0981
OrganismiBordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Taxonomic identifieri257313 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
Proteomesi
  • UP000002676 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 190190Probable chorismate pyruvate-lyasePRO_0000255902Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi257313.BP0981.

Structurei

3D structure databases

ProteinModelPortaliQ7VZD6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UbiC family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105RUM. Bacteria.
COG3161. LUCA.
HOGENOMiHOG000137785.
KOiK03181.
OMAiLWARRSC.
OrthoDBiEOG68H86F.

Family and domain databases

Gene3Di3.40.1410.10. 1 hit.
HAMAPiMF_01632. UbiC.
InterProiIPR007440. Chorismate--pyruvate_lyase.
IPR028978. Chorismate_lyase_/UTRA_dom.
[Graphical view]
PfamiPF04345. Chor_lyase. 1 hit.
[Graphical view]
SUPFAMiSSF64288. SSF64288. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7VZD6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTPIPLARG WLPAAPSTLD PLRKYWLFRP GALTAGLRQL GHVRLRVLAE
60 70 80 90 100
YPTGAPRDEA DGMRIAAQSP VWVREVLMSI DGVDSVVARS LTPLRASHGV
110 120 130 140 150
WQGMRRLLTR PLADMLYHDP GIHRSVFVCR RLAAGVPFHA TAIARAPAGG
160 170 180 190
PEPALWARRS AFWRAGQPLL VAECFLPAFW SLARAPVAPR
Length:190
Mass (Da):20,877
Last modified:October 1, 2003 - v1
Checksum:i9ADE578C94FC2234
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640413 Genomic DNA. Translation: CAE41282.1.
RefSeqiNP_879776.1. NC_002929.2.
WP_010926548.1. NC_002929.2.

Genome annotation databases

EnsemblBacteriaiCAE41282; CAE41282; BP0981.
GeneIDi2664583.
KEGGibpe:BP0981.
PATRICi21155084. VBIBorPer7866_1045.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640413 Genomic DNA. Translation: CAE41282.1.
RefSeqiNP_879776.1. NC_002929.2.
WP_010926548.1. NC_002929.2.

3D structure databases

ProteinModelPortaliQ7VZD6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi257313.BP0981.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAE41282; CAE41282; BP0981.
GeneIDi2664583.
KEGGibpe:BP0981.
PATRICi21155084. VBIBorPer7866_1045.

Phylogenomic databases

eggNOGiENOG4105RUM. Bacteria.
COG3161. LUCA.
HOGENOMiHOG000137785.
KOiK03181.
OMAiLWARRSC.
OrthoDBiEOG68H86F.

Enzyme and pathway databases

UniPathwayiUPA00232.
BioCyciBPER257313:BP0981-MONOMER.

Family and domain databases

Gene3Di3.40.1410.10. 1 hit.
HAMAPiMF_01632. UbiC.
InterProiIPR007440. Chorismate--pyruvate_lyase.
IPR028978. Chorismate_lyase_/UTRA_dom.
[Graphical view]
PfamiPF04345. Chor_lyase. 1 hit.
[Graphical view]
SUPFAMiSSF64288. SSF64288. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica."
    Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S.
    , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J.
    Nat. Genet. 35:32-40(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tohama I / ATCC BAA-589 / NCTC 13251.

Entry informationi

Entry nameiUBIC_BORPE
AccessioniPrimary (citable) accession number: Q7VZD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 1, 2003
Last modified: January 20, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.