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Q7VZ05

- SYW_BORPE

UniProt

Q7VZ05 - SYW_BORPE

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Protein

Tryptophan--tRNA ligase

Gene
trpS, BP1143
Organism
Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei205 – 2051ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. tryptophan-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. tryptophanyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBPER257313:BP1143-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligase (EC:6.1.1.2)
Alternative name(s):
Tryptophanyl-tRNA synthetase
Short name:
TrpRS
Gene namesi
Name:trpS
Ordered Locus Names:BP1143
OrganismiBordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Taxonomic identifieri257313 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
ProteomesiUP000002676: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 451451Tryptophan--tRNA ligaseUniRule annotationPRO_0000136606Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi257313.BP1143.

Structurei

3D structure databases

ProteinModelPortaliQ7VZ05.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi11 – 199"HIGH" regionUniRule annotation
Motifi202 – 2065"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0180.
HOGENOMiHOG000059939.
KOiK01867.
OMAiIDPKKHI.
OrthoDBiEOG686NJQ.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00140_B. Trp_tRNA_synth_B.
InterProiIPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view]
PANTHERiPTHR10055. PTHR10055. 1 hit.
PfamiPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSiPR01039. TRNASYNTHTRP.
TIGRFAMsiTIGR00233. trpS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7VZ05-1 [UniParc]FASTAAdd to Basket

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MNTRVLTGIT TTGTPHLGNY AGAIRPAIQA STQPGVDAFF FLADYHALIK    50
CDDPARVARS RLELAATWLA AGLDPERVTF YRQSDIPEIT ELCWLLTCVT 100
PKGLMNRAHA YKASVDQNAA KGVEPDDGVT MGLFSYPVLM AADILLFNAN 150
QVPVGRDQVQ HLEMARDIAQ RFNHLYGREF FVLPEVVIAE EVATLPGLDG 200
RKMSKSYNNT IPLFEGGAAG LRNATQRIVT DSRLPGEPKD AEASHLYMLY 250
RAFSTQQESM AFRRQLEEGM GWGDAKQALY ERLERDLAPM RERYVELISN 300
PGLIEDILQV GAAKARKLAQ PLVRTLRDAV GLGVLQPAAA KAAQPARKAA 350
KDARFVSFRD EDGSFRFRLL AADGEELLCS VPFANPKEAG ALMRRLQDEA 400
PEQALRGHDD VSYAAWLDGK EVAYGPQAAD AGARDALLAK AREALAQLAA 450
A 451
Length:451
Mass (Da):49,354
Last modified:October 1, 2003 - v1
Checksum:i71133B588B9ADC54
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX640414 Genomic DNA. Translation: CAE41440.1.
RefSeqiNP_879919.1. NC_002929.2.

Genome annotation databases

EnsemblBacteriaiCAE41440; CAE41440; BP1143.
GeneIDi2667412.
KEGGibpe:BP1143.
PATRICi21155456. VBIBorPer7866_1227.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX640414 Genomic DNA. Translation: CAE41440.1 .
RefSeqi NP_879919.1. NC_002929.2.

3D structure databases

ProteinModelPortali Q7VZ05.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257313.BP1143.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE41440 ; CAE41440 ; BP1143 .
GeneIDi 2667412.
KEGGi bpe:BP1143.
PATRICi 21155456. VBIBorPer7866_1227.

Phylogenomic databases

eggNOGi COG0180.
HOGENOMi HOG000059939.
KOi K01867.
OMAi IDPKKHI.
OrthoDBi EOG686NJQ.

Enzyme and pathway databases

BioCyci BPER257313:BP1143-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00140_B. Trp_tRNA_synth_B.
InterProi IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view ]
PANTHERi PTHR10055. PTHR10055. 1 hit.
Pfami PF00579. tRNA-synt_1b. 1 hit.
[Graphical view ]
PRINTSi PR01039. TRNASYNTHTRP.
TIGRFAMsi TIGR00233. trpS. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica."
    Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S.
    , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J.
    Nat. Genet. 35:32-40(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tohama I / ATCC BAA-589 / NCTC 13251.

Entry informationi

Entry nameiSYW_BORPE
AccessioniPrimary (citable) accession number: Q7VZ05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: October 1, 2003
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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