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Q7VZ05 (SYW_BORPE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tryptophan--tRNA ligase

EC=6.1.1.2
Alternative name(s):
Tryptophanyl-tRNA synthetase
Short name=TrpRS
Gene names
Name:trpS
Ordered Locus Names:BP1143
OrganismBordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251) [Reference proteome] [HAMAP]
Taxonomic identifier257313 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella

Protein attributes

Sequence length451 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp). HAMAP-Rule MF_00140

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00140

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00140.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtryptophanyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

tryptophan-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 451451Tryptophan--tRNA ligase HAMAP-Rule MF_00140
PRO_0000136606

Regions

Motif11 – 199"HIGH" region HAMAP-Rule MF_00140
Motif202 – 2065"KMSKS" region HAMAP-Rule MF_00140

Sites

Binding site2051ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7VZ05 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 71133B588B9ADC54

FASTA45149,354
        10         20         30         40         50         60 
MNTRVLTGIT TTGTPHLGNY AGAIRPAIQA STQPGVDAFF FLADYHALIK CDDPARVARS 

        70         80         90        100        110        120 
RLELAATWLA AGLDPERVTF YRQSDIPEIT ELCWLLTCVT PKGLMNRAHA YKASVDQNAA 

       130        140        150        160        170        180 
KGVEPDDGVT MGLFSYPVLM AADILLFNAN QVPVGRDQVQ HLEMARDIAQ RFNHLYGREF 

       190        200        210        220        230        240 
FVLPEVVIAE EVATLPGLDG RKMSKSYNNT IPLFEGGAAG LRNATQRIVT DSRLPGEPKD 

       250        260        270        280        290        300 
AEASHLYMLY RAFSTQQESM AFRRQLEEGM GWGDAKQALY ERLERDLAPM RERYVELISN 

       310        320        330        340        350        360 
PGLIEDILQV GAAKARKLAQ PLVRTLRDAV GLGVLQPAAA KAAQPARKAA KDARFVSFRD 

       370        380        390        400        410        420 
EDGSFRFRLL AADGEELLCS VPFANPKEAG ALMRRLQDEA PEQALRGHDD VSYAAWLDGK 

       430        440        450 
EVAYGPQAAD AGARDALLAK AREALAQLAA A 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX640414 Genomic DNA. Translation: CAE41440.1.
RefSeqNP_879919.1. NC_002929.2.

3D structure databases

ProteinModelPortalQ7VZ05.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING257313.BP1143.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE41440; CAE41440; BP1143.
GeneID2667412.
KEGGbpe:BP1143.
PATRIC21155456. VBIBorPer7866_1227.

Phylogenomic databases

eggNOGCOG0180.
HOGENOMHOG000059939.
KOK01867.
OMAIDPKKHI.
OrthoDBEOG686NJQ.

Enzyme and pathway databases

BioCycBPER257313:BP1143-MONOMER.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_00140_B. Trp_tRNA_synth_B.
InterProIPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view]
PANTHERPTHR10055. PTHR10055. 1 hit.
PfamPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSPR01039. TRNASYNTHTRP.
TIGRFAMsTIGR00233. trpS. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSYW_BORPE
AccessionPrimary (citable) accession number: Q7VZ05
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: October 1, 2003
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries