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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of tryptophan to tRNA(Trp).UniRule annotation

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei143L-tryptophanUniRule annotation1
Binding sitei195ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 12ATPUniRule annotation3
Nucleotide bindingi18 – 19ATPUniRule annotation2
Nucleotide bindingi155 – 157ATPUniRule annotation3
Nucleotide bindingi202 – 206ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBPER257313:G1GSZ-1368-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:BP1143
OrganismiBordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Taxonomic identifieri257313 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
Proteomesi

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001366061 – 451Tryptophan--tRNA ligaseAdd BLAST451

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi257313.BP1143

Structurei

3D structure databases

ProteinModelPortaliQ7VZ05
SMRiQ7VZ05
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi11 – 19"HIGH" regionUniRule annotation9
Motifi202 – 206"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C31 Bacteria
COG0180 LUCA
HOGENOMiHOG000059939
KOiK01867
OMAiRKDDPGH

Family and domain databases

CDDicd00806 TrpRS_core, 1 hit
Gene3Di3.40.50.620, 2 hits
HAMAPiMF_00140_B Trp_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002306 Trp-tRNA-ligase
IPR024109 Trp-tRNA-ligase_bac-type
IPR036913 YegP-like_sf
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PRINTSiPR01039 TRNASYNTHTRP
SUPFAMiSSF160113 SSF160113, 1 hit
TIGRFAMsiTIGR00233 trpS, 1 hit

Sequencei

Sequence statusi: Complete.

Q7VZ05-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTRVLTGIT TTGTPHLGNY AGAIRPAIQA STQPGVDAFF FLADYHALIK
60 70 80 90 100
CDDPARVARS RLELAATWLA AGLDPERVTF YRQSDIPEIT ELCWLLTCVT
110 120 130 140 150
PKGLMNRAHA YKASVDQNAA KGVEPDDGVT MGLFSYPVLM AADILLFNAN
160 170 180 190 200
QVPVGRDQVQ HLEMARDIAQ RFNHLYGREF FVLPEVVIAE EVATLPGLDG
210 220 230 240 250
RKMSKSYNNT IPLFEGGAAG LRNATQRIVT DSRLPGEPKD AEASHLYMLY
260 270 280 290 300
RAFSTQQESM AFRRQLEEGM GWGDAKQALY ERLERDLAPM RERYVELISN
310 320 330 340 350
PGLIEDILQV GAAKARKLAQ PLVRTLRDAV GLGVLQPAAA KAAQPARKAA
360 370 380 390 400
KDARFVSFRD EDGSFRFRLL AADGEELLCS VPFANPKEAG ALMRRLQDEA
410 420 430 440 450
PEQALRGHDD VSYAAWLDGK EVAYGPQAAD AGARDALLAK AREALAQLAA

A
Length:451
Mass (Da):49,354
Last modified:October 1, 2003 - v1
Checksum:i71133B588B9ADC54
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640414 Genomic DNA Translation: CAE41440.1
RefSeqiNP_879919.1, NC_002929.2
WP_010930211.1, NC_002929.2

Genome annotation databases

EnsemblBacteriaiCAE41440; CAE41440; BP1143
GeneIDi2667412
KEGGibpe:BP1143
PATRICifig|257313.5.peg.1227

Entry informationi

Entry nameiSYW_BORPE
AccessioniPrimary (citable) accession number: Q7VZ05
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: October 1, 2003
Last modified: March 28, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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