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Q7VYB7

- LPXB_BORPE

UniProt

Q7VYB7 - LPXB_BORPE

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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciBPER257313:BP1432-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxBUniRule annotation
Synonyms:pgsB
Ordered Locus Names:BP1432
OrganismiBordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Taxonomic identifieri257313 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
ProteomesiUP000002676: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 393393Lipid-A-disaccharide synthasePRO_0000190154Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi257313.BP1432.

Structurei

3D structure databases

ProteinModelPortaliQ7VYB7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiRRSEIRH.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7VYB7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLRIGMVAG EPSGDLLAGR IIAGLQARAP GVHCAGIGGP QMAARGFEAW
60 70 80 90 100
HPMHALTVFG YIDAFKRIPS LLSTYGDVKR RLLAEPPSVF VGIDAPDFNL
110 120 130 140 150
RLEHQLRQAG TPTVHFVGPS IWAWRYERIN KIRAAVSHML VLFPFEEALY
160 170 180 190 200
RKEGIPVTYV GHPLAGVIPM QPDRAAARAR LGIDADARVL AILPGSRSSE
210 220 230 240 250
IRLLAPRFLQ AAAELVRRDP RLQCVVPMVN PQRRAEFEAI ATQHPVPGLR
260 270 280 290 300
CVTAAEGQGE TPVAWSVMEA SNAVLVASGT ATLETALYKR PMVISYVLSP
310 320 330 340 350
WMRRIMAWKS GQQRPYLPWV GLPNVLLRDF AVPELLQDEA TPAALAEATW
360 370 380 390
QALTDEAGAA RIEARFTALH QDLLRDTPAL AAQAILEVAD GAA
Length:393
Mass (Da):42,778
Last modified:October 1, 2003 - v1
Checksum:iB6C206DCF9DF92C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640415 Genomic DNA. Translation: CAE41722.1.
RefSeqiNP_880174.1. NC_002929.2.

Genome annotation databases

EnsemblBacteriaiCAE41722; CAE41722; BP1432.
GeneIDi2665364.
KEGGibpe:BP1432.
PATRICi21156078. VBIBorPer7866_1535.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640415 Genomic DNA. Translation: CAE41722.1 .
RefSeqi NP_880174.1. NC_002929.2.

3D structure databases

ProteinModelPortali Q7VYB7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257313.BP1432.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE41722 ; CAE41722 ; BP1432 .
GeneIDi 2665364.
KEGGi bpe:BP1432.
PATRICi 21156078. VBIBorPer7866_1535.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi RRSEIRH.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci BPER257313:BP1432-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica."
    Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S.
    , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J.
    Nat. Genet. 35:32-40(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tohama I / ATCC BAA-589 / NCTC 13251.

Entry informationi

Entry nameiLPXB_BORPE
AccessioniPrimary (citable) accession number: Q7VYB7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: October 1, 2003
Last modified: October 1, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3