Q7VY92 (AROC_BORPE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chorismate synthase
EC=4.2.3.5

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyase

Gene names

Name:	aroC
Ordered Locus Names:	BP1462

Organism

Bordetella pertussis

Taxonomic identifier

520 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length	353 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300
Cofactor	Reduced flavin By similarity. HAMAP MF_00300
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300
Subunit structure	Homotetramer By similarity. HAMAP MF_00300
Sequence similarities	Belongs to the chorismate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	chorismate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 353	353	Chorismate synthase HAMAP MF_00300		PRO_0000140559

Sequences

	Sequence		Length	Mass (Da)
	Q7VY92 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 64FB840C2B2C783F	FASTA	353	37,304
	10 20 30 40 50 60 MSGNTLGTLF CVTNFGESHG PAIGCVVDGC PPGLPLEAAD IQAELDRRRP GTSRHVTQRQ 70 80 90 100 110 120 EADQVEILSG VYEGVTTGTP IGLLIRNTDA RSKDYSNIAD TFRPGHADFA YWRKYGVRDP 130 140 150 160 170 180 RGGGRSSARL TAPTVAAGAI AKKWLASQFG VRVRGYMSQL GPIAIPFSSW DDVPGNAFYA 190 200 210 220 230 240 PNAAVVPELE AYMDQLRRDG DSVGARIEVV AEGLPAGWGE PIYDRLDADI AHAMMGLNAV 250 260 270 280 290 300 KGVSLGAGFE SIAQRGSEHG DEITPEGFAS NHAGGVLGGI STGQPITVSL AIKPTSSIRV 310 320 330 340 350 ERRSVNRAGE PVMVQTLGRH DPCVGIRATP IAEALLALVL IDHALRQRAQ CGG

References

[1]

"Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica." Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S. , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J. Nat. Genet. 35:32-40(2003) [PubMed: 12910271] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tohama I / ATCC BAA-589 / NCTC 13251.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX640415 Genomic DNA. Translation: CAE41751.1.
RefSeq	NP_880201.1. NC_002929.2.
3D structure databases
ProteinModelPortal	Q7VY92.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2665792.
GenomeReviews	Gene locus BP1462 in contig BX470248_GR.
KEGG	bpe:BP1462.
NMPDR	fig|257313.1.peg.1279.
PATRIC	21156144. VBIBorPer7866_1568.
Phylogenomic databases
HOGENOM	HBG292336.
OMA	SRFTTQR.
PhylomeDB	Q7VY92.
ProtClustDB	PRK05382.
Enzyme and pathway databases
BioCyc	BPER257313:BP1462-MONOMER.
Family and domain databases
HAMAP	MF_00300. Chorismate_synth. [Tree]
InterPro	IPR000453. Chorismate_synth. IPR020541. Chorismate_synthase_CS. [Graphical view]
KO	K01736.
PANTHER	PTHR21085. Chorismate_synth. 1 hit.
Pfam	PF01264. Chorismate_synt. 1 hit. [Graphical view]
PIRSF	PIRSF001456. Chorismate_synth. 1 hit.
SUPFAM	SSF103263. Chorismate_synth. 1 hit.
TIGRFAMs	TIGR00033. AroC. 1 hit.
PROSITE	PS00787. CHORISMATE_SYNTHASE_1. 1 hit. PS00788. CHORISMATE_SYNTHASE_2. 1 hit. PS00789. CHORISMATE_SYNTHASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROC_BORPE

Accession

Primary (citable) accession number: Q7VY92

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2005
Last sequence update:	October 1, 2003
Last modified:	January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program