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Q7VY62 (GSHB_BORPE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione synthetase

EC=6.3.2.3
Alternative name(s):
GSH synthetase
Short name=GSH-S
Short name=GSHase
Glutathione synthase
Gene names
Name:gshB
Synonyms:gsh-II
Ordered Locus Names:BP1499
OrganismBordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251) [Reference proteome] [HAMAP]
Taxonomic identifier257313 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella

Protein attributes

Sequence length318 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione. HAMAP-Rule MF_00162

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity.

Pathway

Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2. HAMAP-Rule MF_00162

Sequence similarities

Belongs to the prokaryotic GSH synthase family.

Contains 1 ATP-grasp domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 318318Glutathione synthetase HAMAP-Rule MF_00162
PRO_0000197455

Regions

Domain129 – 314186ATP-grasp
Nucleotide binding155 – 21157ATP By similarity

Sites

Metal binding2851Magnesium or manganese By similarity
Metal binding2871Magnesium or manganese By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7VY62 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: D17F3719635353D7

FASTA31834,756
        10         20         30         40         50         60 
MHVLFIIDPL PLLKAYKDSS VAMMQALQAR GHTLSVALQG DLYIDAGEVR TRFAPIALRD 

        70         80         90        100        110        120 
GADLHGHDWW RETGAADEAP LARFDAVVMR KDPPFDMEYV YSTHLLEYAQ QQGARVFNSG 

       130        140        150        160        170        180 
AAIRNHPEKL AITEFPDLTT PTLVTRDMAR IRAFHAAQGD VIVKPLDDMG GTGIFRLQRS 

       190        200        210        220        230        240 
EPNLNAILET LTDNGTRTIM AQRYIPEIVK GDKRILLIGG EPMPYSLARI PLAGETRGNL 

       250        260        270        280        290        300 
AAGGRGVAQP LSERDLHLAR TVADRLAGRG LLLVGLDVIG DYITEVNVTS PTCFVEITEQ 

       310 
TGFNVPEMFA VALESAAG 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX640415 Genomic DNA. Translation: CAE41788.1.
RefSeqNP_880235.1. NC_002929.2.

3D structure databases

ProteinModelPortalQ7VY62.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING257313.BP1499.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE41788; CAE41788; BP1499.
GeneID2665804.
KEGGbpe:BP1499.
PATRIC21156230. VBIBorPer7866_1610.

Phylogenomic databases

eggNOGCOG0189.
HOGENOMHOG000265022.
KOK01920.
OMAWVRNYPE.
OrthoDBEOG6WMHWB.

Enzyme and pathway databases

BioCycBPER257313:BP1499-MONOMER.
UniPathwayUPA00142; UER00210.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPMF_00162. GSH_S.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR006284. Glut_synth_pro.
IPR004218. GSHS_ATP-bd.
IPR004215. GSHS_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PfamPF02955. GSH-S_ATP. 1 hit.
PF02951. GSH-S_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01380. glut_syn. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGSHB_BORPE
AccessionPrimary (citable) accession number: Q7VY62
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: October 1, 2003
Last modified: May 14, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways