Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q7VXZ3 (KGUA_BORPE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanylate kinase

EC=2.7.4.8
Alternative name(s):
GMP kinase
Gene names
Name:gmk
Ordered Locus Names:BP1578
OrganismBordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251) [Reference proteome] [HAMAP]
Taxonomic identifier257313 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella

Protein attributes

Sequence length215 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Essential for recycling GMP and indirectly, cGMP By similarity. HAMAP-Rule MF_00328

Catalytic activity

ATP + GMP = ADP + GDP. HAMAP-Rule MF_00328

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00328.

Sequence similarities

Belongs to the guanylate kinase family.

Contains 1 guanylate kinase-like domain.

Sequence caution

The sequence CAE41867.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processpurine nucleotide metabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

guanylate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 215215Guanylate kinase HAMAP-Rule MF_00328
PRO_0000170506

Regions

Domain11 – 189179Guanylate kinase-like
Nucleotide binding18 – 258ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7VXZ3 [UniParc].

Last modified March 15, 2004. Version 2.
Checksum: 82451EBA2453E604

FASTA21523,681
        10         20         30         40         50         60 
MSFLSMSAPS GNVFMVVAPS GAGKSSLVRA LLDRDPSLVL SISCTTRAPR PGEQDGREYR 

        70         80         90        100        110        120 
FVDQAEFARL RDAQQLLEWA EVHGNFYGTP RDRIDEATRA GHDVLLEIDW QGARQVKQRY 

       130        140        150        160        170        180 
PEAIGIFVLP PSIDELESRL KARGQDAPQV IARRLLAAGG EIAHAPECEY VIINQEFSVA 

       190        200        210 
LTELVQIISA ARLRFSSQAV RNAQLFSQLG IPAAH 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX640415 Genomic DNA. Translation: CAE41867.1. Different initiation.
RefSeqNP_880311.1. NC_002929.2.

3D structure databases

ProteinModelPortalQ7VXZ3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING257313.BP1578.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE41867; CAE41867; BP1578.
GeneID2666631.
KEGGbpe:BP1578.
PATRIC21156400. VBIBorPer7866_1694.

Phylogenomic databases

eggNOGCOG0194.
HOGENOMHOG000037638.
KOK00942.
OrthoDBEOG6CP410.

Enzyme and pathway databases

BioCycBPER257313:BP1578-MONOMER.

Family and domain databases

Gene3D3.40.50.300. 3 hits.
HAMAPMF_00328. Guanylate_kinase.
InterProIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00625. Guanylate_kin. 1 hit.
[Graphical view]
SMARTSM00072. GuKc. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR03263. guanyl_kin. 1 hit.
PROSITEPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKGUA_BORPE
AccessionPrimary (citable) accession number: Q7VXZ3
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: March 15, 2004
Last modified: May 14, 2014
This is version 58 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families