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Q7VXX8 (NTPA_BORPE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Non-canonical purine NTP pyrophosphatase

EC=3.6.1.19
Alternative name(s):
Non-standard purine NTP pyrophosphatase
Nucleoside-triphosphate diphosphatase
Nucleoside-triphosphate pyrophosphatase
Short name=NTPase
Gene names
Ordered Locus Names:BP1593
OrganismBordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251) [Reference proteome] [HAMAP]
Taxonomic identifier257313 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella

Protein attributes

Sequence length213 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions By similarity. HAMAP-Rule MF_01405

Catalytic activity

A nucleoside triphosphate + H2O = a nucleotide + diphosphate. HAMAP-Rule MF_01405

Cofactor

Binds 1 divalent metal cation ion per subunit; can use either magnesium or manganese By similarity.

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01405

Sequence similarities

Belongs to the HAM1 NTPase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 213213Non-canonical purine NTP pyrophosphatase HAMAP-Rule MF_01405
PRO_0000178139

Regions

Region17 – 226Substrate binding By similarity
Region78 – 792Substrate binding By similarity

Sites

Metal binding491Magnesium or manganese By similarity
Metal binding781Magnesium or manganese By similarity
Binding site1671Substrate By similarity
Binding site1871Substrate By similarity
Binding site1931Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7VXX8 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: E28CCDC43979B94C

FASTA21322,591
        10         20         30         40         50         60 
MSAEILNPNL RRVVLASNNA GKLREFSALF APLGIELVPQ SELGVSEAEE PHATFVENAL 

        70         80         90        100        110        120 
AKARHASRHT GLPALADDSG LCVVALGGAP GVHSARYAQQ PGGARSDAAN NALLVRELAA 

       130        140        150        160        170        180 
AGDRRAWYVA LLALVRTEND PCPLIGEGLW HGEIVDAPAG EHGFGYDPHF YLPQQGCTAA 

       190        200        210 
QLAPEHKNRI SHRAQALAQL LDKLRATGPV DRP 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX640415 Genomic DNA. Translation: CAE41882.1.
RefSeqNP_880326.1. NC_002929.2.

3D structure databases

ProteinModelPortalQ7VXX8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING257313.BP1593.

Proteomic databases

PRIDEQ7VXX8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE41882; CAE41882; BP1593.
GeneID2666612.
KEGGbpe:BP1593.
PATRIC21156432. VBIBorPer7866_1710.

Phylogenomic databases

eggNOGCOG0127.
HOGENOMHOG000293319.
KOK02428.
OMADFAMAMQ.
OrthoDBEOG6CZQQP.

Enzyme and pathway databases

BioCycBPER257313:BP1593-MONOMER.

Family and domain databases

Gene3D3.90.950.10. 1 hit.
HAMAPMF_01405. Non_canon_purine_NTPase.
InterProIPR002637. Ham1p-like.
IPR029001. ITPase-like_fam.
IPR020922. NTPase.
[Graphical view]
PANTHERPTHR11067. PTHR11067. 1 hit.
PfamPF01725. Ham1p_like. 1 hit.
[Graphical view]
SUPFAMSSF52972. SSF52972. 1 hit.
TIGRFAMsTIGR00042. TIGR00042. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNTPA_BORPE
AccessionPrimary (citable) accession number: Q7VXX8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: October 1, 2003
Last modified: June 11, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families