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Q7VXX8

- NTPA_BORPE

UniProt

Q7VXX8 - NTPA_BORPE

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Protein
Non-canonical purine NTP pyrophosphatase
Gene
BP1593
Organism
Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions By similarity.UniRule annotation

Catalytic activityi

A nucleoside triphosphate + H2O = a nucleotide + diphosphate.UniRule annotation

Cofactori

Binds 1 divalent metal cation ion per subunit; can use either magnesium or manganese By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi49 – 491Magnesium or manganese By similarity
Metal bindingi78 – 781Magnesium or manganese By similarity
Binding sitei167 – 1671Substrate By similarity
Binding sitei187 – 1871Substrate By similarity
Binding sitei193 – 1931Substrate By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. nucleoside-triphosphatase activity Source: InterPro
  3. nucleoside-triphosphate diphosphatase activity Source: UniProtKB-HAMAP
  4. nucleotide binding Source: UniProtKB-KW

GO - Biological processi

  1. nucleoside triphosphate catabolic process Source: InterPro
  2. purine nucleotide metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBPER257313:BP1593-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Non-canonical purine NTP pyrophosphatase (EC:3.6.1.19)
Alternative name(s):
Non-standard purine NTP pyrophosphatase
Nucleoside-triphosphate diphosphatase
Nucleoside-triphosphate pyrophosphatase
Short name:
NTPase
Gene namesi
Ordered Locus Names:BP1593
OrganismiBordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Taxonomic identifieri257313 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
ProteomesiUP000002676: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 213213Non-canonical purine NTP pyrophosphataseUniRule annotation
PRO_0000178139Add
BLAST

Proteomic databases

PRIDEiQ7VXX8.

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi257313.BP1593.

Structurei

3D structure databases

ProteinModelPortaliQ7VXX8.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni17 – 226Substrate binding By similarity
Regioni78 – 792Substrate binding By similarity

Sequence similaritiesi

Belongs to the HAM1 NTPase family.

Phylogenomic databases

eggNOGiCOG0127.
HOGENOMiHOG000293319.
KOiK02428.
OMAiDFAMAMQ.
OrthoDBiEOG6CZQQP.

Family and domain databases

Gene3Di3.90.950.10. 1 hit.
HAMAPiMF_01405. Non_canon_purine_NTPase.
InterProiIPR002637. Ham1p-like.
IPR029001. ITPase-like_fam.
IPR020922. NTPase.
[Graphical view]
PANTHERiPTHR11067. PTHR11067. 1 hit.
PfamiPF01725. Ham1p_like. 1 hit.
[Graphical view]
SUPFAMiSSF52972. SSF52972. 1 hit.
TIGRFAMsiTIGR00042. TIGR00042. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7VXX8-1 [UniParc]FASTAAdd to Basket

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MSAEILNPNL RRVVLASNNA GKLREFSALF APLGIELVPQ SELGVSEAEE    50
PHATFVENAL AKARHASRHT GLPALADDSG LCVVALGGAP GVHSARYAQQ 100
PGGARSDAAN NALLVRELAA AGDRRAWYVA LLALVRTEND PCPLIGEGLW 150
HGEIVDAPAG EHGFGYDPHF YLPQQGCTAA QLAPEHKNRI SHRAQALAQL 200
LDKLRATGPV DRP 213
Length:213
Mass (Da):22,591
Last modified:October 1, 2003 - v1
Checksum:iE28CCDC43979B94C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX640415 Genomic DNA. Translation: CAE41882.1.
RefSeqiNP_880326.1. NC_002929.2.

Genome annotation databases

EnsemblBacteriaiCAE41882; CAE41882; BP1593.
GeneIDi2666612.
KEGGibpe:BP1593.
PATRICi21156432. VBIBorPer7866_1710.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX640415 Genomic DNA. Translation: CAE41882.1 .
RefSeqi NP_880326.1. NC_002929.2.

3D structure databases

ProteinModelPortali Q7VXX8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257313.BP1593.

Proteomic databases

PRIDEi Q7VXX8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE41882 ; CAE41882 ; BP1593 .
GeneIDi 2666612.
KEGGi bpe:BP1593.
PATRICi 21156432. VBIBorPer7866_1710.

Phylogenomic databases

eggNOGi COG0127.
HOGENOMi HOG000293319.
KOi K02428.
OMAi DFAMAMQ.
OrthoDBi EOG6CZQQP.

Enzyme and pathway databases

BioCyci BPER257313:BP1593-MONOMER.

Family and domain databases

Gene3Di 3.90.950.10. 1 hit.
HAMAPi MF_01405. Non_canon_purine_NTPase.
InterProi IPR002637. Ham1p-like.
IPR029001. ITPase-like_fam.
IPR020922. NTPase.
[Graphical view ]
PANTHERi PTHR11067. PTHR11067. 1 hit.
Pfami PF01725. Ham1p_like. 1 hit.
[Graphical view ]
SUPFAMi SSF52972. SSF52972. 1 hit.
TIGRFAMsi TIGR00042. TIGR00042. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica."
    Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S.
    , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J.
    Nat. Genet. 35:32-40(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tohama I / ATCC BAA-589 / NCTC 13251.

Entry informationi

Entry nameiNTPA_BORPE
AccessioniPrimary (citable) accession number: Q7VXX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: October 1, 2003
Last modified: June 11, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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