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Q7VXX8

- NTPA_BORPE

UniProt

Q7VXX8 - NTPA_BORPE

Protein

Non-canonical purine NTP pyrophosphatase

Gene

BP1593

Organism
Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions.UniRule annotation

    Catalytic activityi

    A nucleoside triphosphate + H2O = a nucleotide + diphosphate.UniRule annotation

    Cofactori

    Binds 1 divalent metal cation ion per subunit; can use either magnesium or manganese.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi49 – 491Magnesium or manganeseUniRule annotation
    Metal bindingi78 – 781Magnesium or manganeseUniRule annotation
    Binding sitei167 – 1671SubstrateUniRule annotation
    Binding sitei187 – 1871SubstrateUniRule annotation
    Binding sitei193 – 1931SubstrateUniRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. nucleoside-triphosphatase activity Source: InterPro
    3. nucleoside-triphosphate diphosphatase activity Source: UniProtKB-HAMAP
    4. nucleotide binding Source: UniProtKB-KW

    GO - Biological processi

    1. nucleoside triphosphate catabolic process Source: InterPro
    2. purine nucleotide metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Nucleotide metabolism

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBPER257313:BP1593-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Non-canonical purine NTP pyrophosphataseUniRule annotation (EC:3.6.1.19UniRule annotation)
    Alternative name(s):
    Non-standard purine NTP pyrophosphataseUniRule annotation
    Nucleoside-triphosphate diphosphataseUniRule annotation
    Nucleoside-triphosphate pyrophosphataseUniRule annotation
    Short name:
    NTPaseUniRule annotation
    Gene namesi
    Ordered Locus Names:BP1593
    OrganismiBordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
    Taxonomic identifieri257313 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
    ProteomesiUP000002676: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 213213Non-canonical purine NTP pyrophosphatasePRO_0000178139Add
    BLAST

    Proteomic databases

    PRIDEiQ7VXX8.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi257313.BP1593.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7VXX8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni17 – 226Substrate bindingUniRule annotation
    Regioni78 – 792Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the HAM1 NTPase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0127.
    HOGENOMiHOG000293319.
    KOiK02428.
    OMAiDFAMAMQ.
    OrthoDBiEOG6CZQQP.

    Family and domain databases

    Gene3Di3.90.950.10. 1 hit.
    HAMAPiMF_01405. Non_canon_purine_NTPase.
    InterProiIPR002637. Ham1p-like.
    IPR029001. ITPase-like_fam.
    IPR020922. NTPase.
    [Graphical view]
    PANTHERiPTHR11067. PTHR11067. 1 hit.
    PfamiPF01725. Ham1p_like. 1 hit.
    [Graphical view]
    SUPFAMiSSF52972. SSF52972. 1 hit.
    TIGRFAMsiTIGR00042. TIGR00042. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q7VXX8-1 [UniParc]FASTAAdd to Basket

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    MSAEILNPNL RRVVLASNNA GKLREFSALF APLGIELVPQ SELGVSEAEE    50
    PHATFVENAL AKARHASRHT GLPALADDSG LCVVALGGAP GVHSARYAQQ 100
    PGGARSDAAN NALLVRELAA AGDRRAWYVA LLALVRTEND PCPLIGEGLW 150
    HGEIVDAPAG EHGFGYDPHF YLPQQGCTAA QLAPEHKNRI SHRAQALAQL 200
    LDKLRATGPV DRP 213
    Length:213
    Mass (Da):22,591
    Last modified:October 1, 2003 - v1
    Checksum:iE28CCDC43979B94C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX640415 Genomic DNA. Translation: CAE41882.1.
    RefSeqiNP_880326.1. NC_002929.2.

    Genome annotation databases

    EnsemblBacteriaiCAE41882; CAE41882; BP1593.
    GeneIDi2666612.
    KEGGibpe:BP1593.
    PATRICi21156432. VBIBorPer7866_1710.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX640415 Genomic DNA. Translation: CAE41882.1 .
    RefSeqi NP_880326.1. NC_002929.2.

    3D structure databases

    ProteinModelPortali Q7VXX8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 257313.BP1593.

    Proteomic databases

    PRIDEi Q7VXX8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE41882 ; CAE41882 ; BP1593 .
    GeneIDi 2666612.
    KEGGi bpe:BP1593.
    PATRICi 21156432. VBIBorPer7866_1710.

    Phylogenomic databases

    eggNOGi COG0127.
    HOGENOMi HOG000293319.
    KOi K02428.
    OMAi DFAMAMQ.
    OrthoDBi EOG6CZQQP.

    Enzyme and pathway databases

    BioCyci BPER257313:BP1593-MONOMER.

    Family and domain databases

    Gene3Di 3.90.950.10. 1 hit.
    HAMAPi MF_01405. Non_canon_purine_NTPase.
    InterProi IPR002637. Ham1p-like.
    IPR029001. ITPase-like_fam.
    IPR020922. NTPase.
    [Graphical view ]
    PANTHERi PTHR11067. PTHR11067. 1 hit.
    Pfami PF01725. Ham1p_like. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52972. SSF52972. 1 hit.
    TIGRFAMsi TIGR00042. TIGR00042. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica."
      Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S.
      , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J.
      Nat. Genet. 35:32-40(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tohama I / ATCC BAA-589 / NCTC 13251.

    Entry informationi

    Entry nameiNTPA_BORPE
    AccessioniPrimary (citable) accession number: Q7VXX8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3