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Q7VXD2 (KTHY_BORPE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidylate kinase

EC=2.7.4.9
Alternative name(s):
dTMP kinase
Gene names
Name:tmk
Ordered Locus Names:BP1847
OrganismBordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251) [Reference proteome] [HAMAP]
Taxonomic identifier257313 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella

Protein attributes

Sequence length208 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis By similarity. HAMAP-Rule MF_00165

Catalytic activity

ATP + dTMP = ADP + dTDP. HAMAP-Rule MF_00165

Sequence similarities

Belongs to the thymidylate kinase family.

Ontologies

Keywords
   Biological processNucleotide biosynthesis
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdTDP biosynthetic process

Inferred from electronic annotation. Source: InterPro

dTTP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

thymidylate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 208208Thymidylate kinase HAMAP-Rule MF_00165
PRO_0000155245

Regions

Nucleotide binding12 – 198ATP Potential

Sequences

Sequence LengthMass (Da)Tools
Q7VXD2 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 1FC035D84CD5D249

FASTA20823,354
        10         20         30         40         50         60 
MTPRGRFITL EGVDGAGKST HTAWMVQALR DLGLTVLATR EPGGTPVGEK LRELLLSEPM 

        70         80         90        100        110        120 
ALETETLLMF AARCEHVREV IAPALARGEW VVCDRFTDAS YAYQGGGRQL GAARVAALEQ 

       130        140        150        160        170        180 
WVHPDLQPDR TWLFDVPLDV ARARLARSRQ LDRFEREEDA FFERTRAAYH ERARSSDGRI 

       190        200 
RIIDSSRPLE VVRAQLDSEV RELVAQAA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX640416 Genomic DNA. Translation: CAE42133.1.
RefSeqNP_880549.1. NC_002929.2.

3D structure databases

ProteinModelPortalQ7VXD2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING257313.BP1847.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE42133; CAE42133; BP1847.
GeneID2667128.
KEGGbpe:BP1847.
PATRIC21156984. VBIBorPer7866_1985.

Phylogenomic databases

eggNOGCOG0125.
HOGENOMHOG000229078.
KOK00943.
OMAKSSHIDA.
OrthoDBEOG64JFSH.

Enzyme and pathway databases

BioCycBPER257313:BP1847-MONOMER.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
HAMAPMF_00165. Thymidylate_kinase.
InterProIPR027417. P-loop_NTPase.
IPR018094. Thymidylate_kinase.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00041. DTMP_kinase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKTHY_BORPE
AccessionPrimary (citable) accession number: Q7VXD2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: October 1, 2003
Last modified: May 14, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families