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Q7VXD2

- KTHY_BORPE

UniProt

Q7VXD2 - KTHY_BORPE

Protein

Thymidylate kinase

Gene

tmk

Organism
Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.UniRule annotation

    Catalytic activityi

    ATP + dTMP = ADP + dTDP.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi12 – 198ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidylate kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dTDP biosynthetic process Source: InterPro
    2. dTTP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Nucleotide biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBPER257313:BP1847-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidylate kinaseUniRule annotation (EC:2.7.4.9UniRule annotation)
    Alternative name(s):
    dTMP kinaseUniRule annotation
    Gene namesi
    Name:tmkUniRule annotation
    Ordered Locus Names:BP1847
    OrganismiBordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
    Taxonomic identifieri257313 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
    ProteomesiUP000002676: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 208208Thymidylate kinasePRO_0000155245Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi257313.BP1847.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7VXD2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidylate kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0125.
    HOGENOMiHOG000229078.
    KOiK00943.
    OMAiKSSHIDA.
    OrthoDBiEOG64JFSH.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    HAMAPiMF_00165. Thymidylate_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR018094. Thymidylate_kinase.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00041. DTMP_kinase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q7VXD2-1 [UniParc]FASTAAdd to Basket

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    MTPRGRFITL EGVDGAGKST HTAWMVQALR DLGLTVLATR EPGGTPVGEK    50
    LRELLLSEPM ALETETLLMF AARCEHVREV IAPALARGEW VVCDRFTDAS 100
    YAYQGGGRQL GAARVAALEQ WVHPDLQPDR TWLFDVPLDV ARARLARSRQ 150
    LDRFEREEDA FFERTRAAYH ERARSSDGRI RIIDSSRPLE VVRAQLDSEV 200
    RELVAQAA 208
    Length:208
    Mass (Da):23,354
    Last modified:October 1, 2003 - v1
    Checksum:i1FC035D84CD5D249
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX640416 Genomic DNA. Translation: CAE42133.1.
    RefSeqiNP_880549.1. NC_002929.2.

    Genome annotation databases

    EnsemblBacteriaiCAE42133; CAE42133; BP1847.
    GeneIDi2667128.
    KEGGibpe:BP1847.
    PATRICi21156984. VBIBorPer7866_1985.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX640416 Genomic DNA. Translation: CAE42133.1 .
    RefSeqi NP_880549.1. NC_002929.2.

    3D structure databases

    ProteinModelPortali Q7VXD2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 257313.BP1847.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE42133 ; CAE42133 ; BP1847 .
    GeneIDi 2667128.
    KEGGi bpe:BP1847.
    PATRICi 21156984. VBIBorPer7866_1985.

    Phylogenomic databases

    eggNOGi COG0125.
    HOGENOMi HOG000229078.
    KOi K00943.
    OMAi KSSHIDA.
    OrthoDBi EOG64JFSH.

    Enzyme and pathway databases

    BioCyci BPER257313:BP1847-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    HAMAPi MF_00165. Thymidylate_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR018094. Thymidylate_kinase.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00041. DTMP_kinase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica."
      Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S.
      , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J.
      Nat. Genet. 35:32-40(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tohama I / ATCC BAA-589 / NCTC 13251.

    Entry informationi

    Entry nameiKTHY_BORPE
    AccessioniPrimary (citable) accession number: Q7VXD2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2004
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3