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Q7VXA0 (UPPP_BORPE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Synonyms:bacA, upk
Ordered Locus Names:BP1904
OrganismBordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251) [Reference proteome] [HAMAP]
Taxonomic identifier257313 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella

Protein attributes

Sequence length287 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 287287Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000151117

Regions

Transmembrane6 – 2621Helical; Potential
Transmembrane45 – 6521Helical; Potential
Transmembrane89 – 10921Helical; Potential
Transmembrane111 – 13121Helical; Potential
Transmembrane204 – 22421Helical; Potential
Transmembrane238 – 25821Helical; Potential
Transmembrane266 – 28621Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q7VXA0 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 25E1ECEA60E16A13

FASTA28731,000
        10         20         30         40         50         60 
MTDSTLHLLK AFFLGIVEGL TEFIPVSSTG HLIVIGDWIN FASSSGKVFE VVIQFGSILA 

        70         80         90        100        110        120 
VMWIFRARLW QLIRGTLTGV RQEVNFTRNL LLAFLPAAVI GAIFIKSIKQ VFYHPGVVAV 

       130        140        150        160        170        180 
TLVVGGFIML WVERRAPHTP GDAPGAADDT ASDERASAHT LEQISAKQAL GVGVAQCVAM 

       190        200        210        220        230        240 
IPGVSRSGAT IIGGMIAGIQ RKTATEFSFF LAMPTMLGAA VYDLYRNIGL LSQHDMSAIA 

       250        260        270        280 
VGFVAAFLSA LVVVRAVLRF VANHTYRVFA WYRIALGLVV AAWIYAK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX640416 Genomic DNA. Translation: CAE42186.1.
RefSeqNP_880590.1. NC_002929.2.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING257313.BP1904.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE42186; CAE42186; BP1904.
GeneID2665425.
KEGGbpe:BP1904.
PATRIC21157098. VBIBorPer7866_2044.

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAMGASKRS.
OrthoDBEOG6QP13M.
ProtClustDBPRK00281.

Enzyme and pathway databases

BioCycBPER257313:BP1904-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUPPP_BORPE
AccessionPrimary (citable) accession number: Q7VXA0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: October 1, 2003
Last modified: February 19, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families