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Q7VX83 (ASPD2_BORPE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable L-aspartate dehydrogenase 2
EC=1.4.1.21
Gene names
Name:nadX2
Ordered Locus Names:BP1922
OrganismBordetella pertussis
Taxonomic identifier520 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length267 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate By similarity. HAMAP MF_01265

Catalytic activity

L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H. HAMAP MF_01265

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (dehydrogenase route): step 1/1. HAMAP MF_01265

Miscellaneous

The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia By similarity. HAMAP MF_01265

Sequence similarities

Belongs to the L-aspartate dehydrogenase family.

Ontologies

Keywords
   Biological processPyridine nucleotide biosynthesis
   LigandNAD
NADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processNAD biosynthetic process

Inferred from electronic annotation. Source: InterPro

NADP catabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionNADP binding

Inferred from electronic annotation. Source: InterPro

aspartate dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 267267Probable L-aspartate dehydrogenase 2 HAMAP MF_01265
PRO_0000144886

Sites

Active site2191 By similarity
Binding site1231NAD; via amide nitrogen By similarity
Binding site1891NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7VX83 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: B52ACD7FEDE4EB4D

FASTA26727,736
        10         20         30         40         50         60 
MTHRIAFIGL GAIASDVAAG LLADAAQPCQ LAALTRNAAD LPPALAGRVA LLDGLPGLLA 

        70         80         90        100        110        120 
WRPDLVVEAA GQQAIAEHAE GCLTAGLDMI ICSAGALADD ALRARLIAAA EAGGARIRVP 

       130        140        150        160        170        180 
AGAIAGLDYL QAVAGRDDAE VVYESRKPVA AWRAELPGMG IDPDTLAESR TLFSGPAREA 

       190        200        210        220        230        240 
ALRFPKNLNV AATLALAGIG MTRTRVEVVV DPQARGNQHR IQVRSPLGEM QIELVNAPSP 

       250        260 
ANPKTSWLVA HSVLATIRRH LARFTIG

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX640416 Genomic DNA. Translation: CAE42204.1.
RefSeqNP_880608.1. NC_002929.2.

3D structure databases

ProteinModelPortalQ7VX83.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2665480.
GenomeReviewsGene locus BP1922 in contig BX470248_GR.
KEGGbpe:BP1922.
NMPDRfig|257313.1.peg.1684.
PATRIC21157140. VBIBorPer7866_2064.

Phylogenomic databases

HOGENOMHBG649642.
OMALATIRRH.
ProtClustDBPRK13301.

Enzyme and pathway databases

BioCycBPER257313:BP1922-MONOMER.

Family and domain databases

HAMAPMF_01265. NadX.
[Tree]
InterProIPR005106. Asp/hSer_DH_NAD-bd.
IPR002811. Asp_DH.
IPR011182. Asp_DH_NAD_syn.
IPR020626. Asp_DH_NAD_syn_prok.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK06989.
PfamPF01958. DUF108. 1 hit.
PF03447. NAD_binding_3. 1 hit.
[Graphical view]
PIRSFPIRSF005227. Asp_dh_NAD_syn. 1 hit.
ProtoNetSearch...

Entry information

Entry nameASPD2_BORPE
AccessionPrimary (citable) accession number: Q7VX83
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: October 1, 2003
Last modified: January 25, 2012
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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