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Q7VX83

- ASPD2_BORPE

UniProt

Q7VX83 - ASPD2_BORPE

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Protein
Probable L-aspartate dehydrogenase 2
Gene
nadX2, BP1922
Organism
Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate By similarity.UniRule annotation

Catalytic activityi

L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei123 – 1231NAD; via amide nitrogen By similarity
Binding sitei189 – 1891NAD By similarity
Active sitei219 – 2191 By similarity

GO - Molecular functioni

  1. NAD binding Source: UniProtKB-HAMAP
  2. NADP binding Source: UniProtKB-HAMAP
  3. aspartate dehydrogenase activity Source: UniProtKB-EC
  4. oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-HAMAP
  2. NADP catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

NAD, NADP

Enzyme and pathway databases

BioCyciBPER257313:BP1922-MONOMER.
UniPathwayiUPA00253; UER00456.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable L-aspartate dehydrogenase 2 (EC:1.4.1.21)
Gene namesi
Name:nadX2
Ordered Locus Names:BP1922
OrganismiBordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Taxonomic identifieri257313 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
ProteomesiUP000002676: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 267267Probable L-aspartate dehydrogenase 2UniRule annotation
PRO_0000144886Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi257313.BP1922.

Structurei

3D structure databases

ProteinModelPortaliQ7VX83.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1712.
HOGENOMiHOG000206326.
KOiK06989.
OMAiRARGNQH.
OrthoDBiEOG6ND0JC.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01265. NadX.
InterProiIPR005106. Asp/hSer_DH_NAD-bd.
IPR002811. Asp_DH.
IPR020626. Asp_DH_prok.
IPR011182. L-Asp_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01958. DUF108. 1 hit.
PF03447. NAD_binding_3. 1 hit.
[Graphical view]
PIRSFiPIRSF005227. Asp_dh_NAD_syn. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7VX83-1 [UniParc]FASTAAdd to Basket

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MTHRIAFIGL GAIASDVAAG LLADAAQPCQ LAALTRNAAD LPPALAGRVA    50
LLDGLPGLLA WRPDLVVEAA GQQAIAEHAE GCLTAGLDMI ICSAGALADD 100
ALRARLIAAA EAGGARIRVP AGAIAGLDYL QAVAGRDDAE VVYESRKPVA 150
AWRAELPGMG IDPDTLAESR TLFSGPAREA ALRFPKNLNV AATLALAGIG 200
MTRTRVEVVV DPQARGNQHR IQVRSPLGEM QIELVNAPSP ANPKTSWLVA 250
HSVLATIRRH LARFTIG 267
Length:267
Mass (Da):27,736
Last modified:October 1, 2003 - v1
Checksum:iB52ACD7FEDE4EB4D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX640416 Genomic DNA. Translation: CAE42204.1.
RefSeqiNP_880608.1. NC_002929.2.

Genome annotation databases

EnsemblBacteriaiCAE42204; CAE42204; BP1922.
GeneIDi2665480.
KEGGibpe:BP1922.
PATRICi21157140. VBIBorPer7866_2064.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX640416 Genomic DNA. Translation: CAE42204.1 .
RefSeqi NP_880608.1. NC_002929.2.

3D structure databases

ProteinModelPortali Q7VX83.
ModBasei Search...

Protein-protein interaction databases

STRINGi 257313.BP1922.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE42204 ; CAE42204 ; BP1922 .
GeneIDi 2665480.
KEGGi bpe:BP1922.
PATRICi 21157140. VBIBorPer7866_2064.

Phylogenomic databases

eggNOGi COG1712.
HOGENOMi HOG000206326.
KOi K06989.
OMAi RARGNQH.
OrthoDBi EOG6ND0JC.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00456 .
BioCyci BPER257313:BP1922-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01265. NadX.
InterProi IPR005106. Asp/hSer_DH_NAD-bd.
IPR002811. Asp_DH.
IPR020626. Asp_DH_prok.
IPR011182. L-Asp_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF01958. DUF108. 1 hit.
PF03447. NAD_binding_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF005227. Asp_dh_NAD_syn. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica."
    Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S.
    , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J.
    Nat. Genet. 35:32-40(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tohama I / ATCC BAA-589 / NCTC 13251.

Entry informationi

Entry nameiASPD2_BORPE
AccessioniPrimary (citable) accession number: Q7VX83
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: October 1, 2003
Last modified: September 3, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia By similarity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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