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Q7VWY7 (SYL_BORPE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:BP2044
OrganismBordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251) [Reference proteome] [HAMAP]
Taxonomic identifier257313 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella

Protein attributes

Sequence length885 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 885885Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_0000151982

Regions

Motif48 – 5811"HIGH" region HAMAP-Rule MF_00049
Motif639 – 6435"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site6421ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7VWY7 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: D160F6425F433A1C

FASTA88598,964
        10         20         30         40         50         60 
MQERYQPNSV EAAAQQTWQA RDAYLVHEHA KNPDGSEKPK FYACSMLPYP SGKLHMGHVR 

        70         80         90        100        110        120 
NYTINDMMAR QLRMRGYNVL MPMGWDAFGM PAENAAIKSK VPPAKWTYDN IAYMKKQMKA 

       130        140        150        160        170        180 
MGLAIDWSRE MCACDPKYYK WNQWLFLKML EKGIAYRKTQ VVNWDPVDQT VLANEQVIDG 

       190        200        210        220        230        240 
RGWRSGAPVE KREIPGYYLR ITDYAEELLD QVSTNLPGWP ERVRLMQENW IGKSEGLRFA 

       250        260        270        280        290        300 
FPHRIAGADG KLIQDGKLYV FTTRADTIMG VTFCAVAPEH PLATHAAQSN PALAAFVEQC 

       310        320        330        340        350        360 
KLGGTTEAEM ATREKEGMPT GLTVTHPLTG AEIDVWVGNY VLMTYGDGAV MGVPAHDERD 

       370        380        390        400        410        420 
FAFARKYGLP IRQVVALEGK TYSTDAWQEW YGDKQAGRTV NSGKYDGLAY QAAVDAIAAD 

       430        440        450        460        470        480 
LAAQGVGEKQ TTWRLRDWGI SRQRYWGTPI PIIHCADCGP VPVPEQDLPV VLPDDLIPDG 

       490        500        510        520        530        540 
SGNPLAKNEA FLSCSCPRCG KPARRETDTM DTFVDSSWYF MRYTSPDNDQ AMVDARNDYW 

       550        560        570        580        590        600 
MPMDQYIGGI EHAVLHLLYA RFWTKVMRDL GLLNFDEPFT KLLCQGMVLN HIYSRKTPQG 

       610        620        630        640        650        660 
GIEYFWPEEV DNVYDAKGAI VGAKLQRDGS EVNYGGVGTM SKSKNNGVDP QSLIDTLGAD 

       670        680        690        700        710        720 
TARLFVMFAS PPEQTLEWSD SGVEGANRFL RRLWALGYAQ REAVGRGLAT GADWAQAPAP 

       730        740        750        760        770        780 
VKELRREVYG LLKQADYDYQ RIQYNTVVSA CMKMLNAIDD APLPEGPAAD AARAETLGLL 

       790        800        810        820        830        840 
LRVLYPVVPH ITWHLWQDLG YAEHLGDLLD APWPHVDEAA LVADEIELML QVNGKLRGSI 

       850        860        870        880 
RVAAKAPKED IERIAAAQEE VARFLEGRPP KRVIVVPGKL VNVVG 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX640417 Genomic DNA. Translation: CAE42323.1.
RefSeqNP_880711.1. NC_002929.2.

3D structure databases

ProteinModelPortalQ7VWY7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING257313.BP2044.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE42323; CAE42323; BP2044.
GeneID2665774.
KEGGbpe:BP2044.
PATRIC21157416. VBIBorPer7866_2196.

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200747.
KOK01869.
OMAVVHCDAC.
OrthoDBEOG63Z74X.

Enzyme and pathway databases

BioCycBPER257313:BP2044-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_BORPE
AccessionPrimary (citable) accession number: Q7VWY7
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: October 1, 2003
Last modified: May 14, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries