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Q7VWV5

- QUEF_BORPE

UniProt

Q7VWV5 - QUEF_BORPE

Protein

NADPH-dependent 7-cyano-7-deazaguanine reductase

Gene

queF

Organism
Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).UniRule annotation

    Catalytic activityi

    7-aminomethyl-7-carbaguanine + 2 NADP+ = 7-cyano-7-carbaguanine + 2 NADPH.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei180 – 1801Thioimide intermediateUniRule annotation
    Active sitei187 – 1871Proton donorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi82 – 832NADPHUniRule annotation
    Nucleotide bindingi248 – 2492NADPHUniRule annotation

    GO - Molecular functioni

    1. oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor Source: InterPro
    2. preQ1 synthase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. queuosine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Queuosine biosynthesis

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciBPER257313:BP2084-MONOMER.
    UniPathwayiUPA00392.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADPH-dependent 7-cyano-7-deazaguanine reductaseUniRule annotation (EC:1.7.1.13UniRule annotation)
    Alternative name(s):
    7-cyano-7-carbaguanine reductaseUniRule annotation
    NADPH-dependent nitrile oxidoreductaseUniRule annotation
    PreQ(0) reductaseUniRule annotation
    Gene namesi
    Name:queFUniRule annotation
    Ordered Locus Names:BP2084
    OrganismiBordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
    Taxonomic identifieri257313 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
    ProteomesiUP000002676: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 273273NADPH-dependent 7-cyano-7-deazaguanine reductasePRO_0000163022Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi257313.BP2084.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7VWV5.
    SMRiQ7VWV5. Positions 14-273.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni80 – 823Substrate bindingUniRule annotation
    Regioni219 – 2202Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0780.
    HOGENOMiHOG000273755.
    KOiK06879.
    OMAiPQINQEG.
    OrthoDBiEOG6D5G0M.

    Family and domain databases

    HAMAPiMF_00817. QueF_type2.
    InterProiIPR029500. QueF.
    IPR029139. QueF_N.
    IPR016428. QueF_type2.
    [Graphical view]
    PfamiPF14489. QueF. 1 hit.
    PF14819. QueF_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF004750. Nitrile_oxidored_YqcD_prd. 1 hit.
    TIGRFAMsiTIGR03138. QueF. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q7VWV5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLSNAPLGQ HVAYPSQYDP GLLFPIPRAT NRASLQLGAA LPFTGVDLWN    50
    AYELSWLDAR GKPRVAMATF SFPADSPNIV ESKSFKLYLN SFNQTRLPNA 100
    QALRDRLERD LAAAAGAPVG LEFISPQRFG ELNMAELDGI YIDKLDIEID 150
    TYEPAPQLLQ CAPGDEVEET LATRLLKSNC PVTGQPDWAS LQVRYRGRPI 200
    DRAALLKYVV SFRQHAEFHE HCVERIFGDI MRACQPRQLT VYARYTRRGG 250
    LDINPWRSNF ESAPPADVRT ARQ 273
    Length:273
    Mass (Da):30,621
    Last modified:October 1, 2003 - v1
    Checksum:i2746EE8D2556FA78
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX640417 Genomic DNA. Translation: CAE42362.1.
    RefSeqiNP_880745.1. NC_002929.2.

    Genome annotation databases

    EnsemblBacteriaiCAE42362; CAE42362; BP2084.
    GeneIDi2667196.
    KEGGibpe:BP2084.
    PATRICi21157506. VBIBorPer7866_2241.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX640417 Genomic DNA. Translation: CAE42362.1 .
    RefSeqi NP_880745.1. NC_002929.2.

    3D structure databases

    ProteinModelPortali Q7VWV5.
    SMRi Q7VWV5. Positions 14-273.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 257313.BP2084.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE42362 ; CAE42362 ; BP2084 .
    GeneIDi 2667196.
    KEGGi bpe:BP2084.
    PATRICi 21157506. VBIBorPer7866_2241.

    Phylogenomic databases

    eggNOGi COG0780.
    HOGENOMi HOG000273755.
    KOi K06879.
    OMAi PQINQEG.
    OrthoDBi EOG6D5G0M.

    Enzyme and pathway databases

    UniPathwayi UPA00392 .
    BioCyci BPER257313:BP2084-MONOMER.

    Family and domain databases

    HAMAPi MF_00817. QueF_type2.
    InterProi IPR029500. QueF.
    IPR029139. QueF_N.
    IPR016428. QueF_type2.
    [Graphical view ]
    Pfami PF14489. QueF. 1 hit.
    PF14819. QueF_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF004750. Nitrile_oxidored_YqcD_prd. 1 hit.
    TIGRFAMsi TIGR03138. QueF. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica."
      Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S.
      , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J.
      Nat. Genet. 35:32-40(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tohama I / ATCC BAA-589 / NCTC 13251.

    Entry informationi

    Entry nameiQUEF_BORPE
    AccessioniPrimary (citable) accession number: Q7VWV5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3