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Q7VWL4 (DER_BORPE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTPase Der
Alternative name(s):
GTP-binding protein EngA
Gene names
Name:der
Synonyms:engA
Ordered Locus Names:BP2195
OrganismBordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251) [Reference proteome] [HAMAP]
Taxonomic identifier257313 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella

Protein attributes

Sequence length451 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

GTPase that plays an essential role in the late steps of ribosome biogenesis By similarity. HAMAP-Rule MF_00195

Subunit structure

Associates with the 50S ribosomal subunit By similarity.

Sequence similarities

Belongs to the Era/MnmE GTP-binding protein family. Der subfamily.

Contains 2 G (guanine nucleotide-binding) domains.

Contains 1 KH-like domain.

Ontologies

Keywords
   Biological processRibosome biogenesis
   DomainRepeat
   LigandGTP-binding
Nucleotide-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processribosome biogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

nucleoside-triphosphatase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 451451GTPase Der HAMAP-Rule MF_00195
PRO_0000178970

Regions

Domain16 – 123108G 1
Domain197 – 305109G 2
Domain359 – 44486KH-like
Nucleotide binding11 – 188GTP 1 Potential
Nucleotide binding58 – 625GTP 1 Potential
Nucleotide binding122 – 1254GTP 1 Potential
Nucleotide binding192 – 1998GTP 2 Potential
Nucleotide binding239 – 2435GTP 2 Potential
Nucleotide binding304 – 3074GTP 2 Potential

Sequences

Sequence LengthMass (Da)Tools
Q7VWL4 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 2275B51A179C57FB

FASTA45149,428
        10         20         30         40         50         60 
MSFKPVVALV GRPNVGKSTL FNRLTRSRAA LVADFSGLTR DRHYGEGRVG DTPFLVIDTG 

        70         80         90        100        110        120 
GFEPVAKDGI LAEMARQTRQ AIAEADVVVF LVDARAGVNA HDHEIARLLR KSGQQRVLLA 

       130        140        150        160        170        180 
VNKAEGMGVG NATGDFHELG LGEPHPISAA HGDGIVDLIE IALSGLVAPP ADTGEQLEQD 

       190        200        210        220        230        240 
VVDHRIKLAI VGRPNVGKST LINTLLGEER VIAFDMPGTT RDAIEIDFER DGRKYTLIDT 

       250        260        270        280        290        300 
AGLRKRGKVF EAIEKFSVIK TLQAIEASNV VLLMIDAQAE VSEQDAHIAG FVLETGRAVV 

       310        320        330        340        350        360 
VAINKWDGLD SDQRERIERE FQRKLRFLGF ARMHTISALK GQGVKPLLKS VNAAHAAAFA 

       370        380        390        400        410        420 
KLSTPRLTRE LQAAVEQQPP PRKGIFRPKM RYAHQGGQNP PLIVIHGNAL DAVPDSYRRY 

       430        440        450 
LETRFRNAFD LAGTPLRIEF KSSRNPYVQE N 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX640417 Genomic DNA. Translation: CAE42473.1.
RefSeqNP_880843.1. NC_002929.2.

3D structure databases

ProteinModelPortalQ7VWL4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING257313.BP2195.

Proteomic databases

PRIDEQ7VWL4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE42473; CAE42473; BP2195.
GeneID2667295.
KEGGbpe:BP2195.
PATRIC21157764. VBIBorPer7866_2369.

Phylogenomic databases

eggNOGCOG1160.
HOGENOMHOG000242862.
KOK03977.
OMAYLENTYR.
OrthoDBEOG6DC6K1.
ProtClustDBPRK00093.

Enzyme and pathway databases

BioCycBPER257313:BP2195-MONOMER.

Family and domain databases

Gene3D3.30.300.20. 1 hit.
3.40.50.300. 2 hits.
HAMAPMF_00195. GTPase_Der.
InterProIPR003593. AAA+_ATPase.
IPR016484. GTP-bd_EngA.
IPR006073. GTP_binding_domain.
IPR015946. KH_dom-like_a/b.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
[Graphical view]
PANTHERPTHR11649:SF5. PTHR11649:SF5. 1 hit.
PfamPF01926. MMR_HSR1. 2 hits.
[Graphical view]
PIRSFPIRSF006485. GTP-binding_EngA. 1 hit.
PRINTSPR00326. GTP1OBG.
SMARTSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMSSF52540. SSF52540. 2 hits.
TIGRFAMsTIGR03594. GTPase_EngA. 1 hit.
TIGR00231. small_GTP. 2 hits.
ProtoNetSearch...

Entry information

Entry nameDER_BORPE
AccessionPrimary (citable) accession number: Q7VWL4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: October 1, 2003
Last modified: April 16, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families