ID   Q7VWI8_BORPE            Unreviewed;       673 AA.
AC   Q7VWI8;
DT   01-OCT-2003, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2003, sequence version 1.
DT   27-MAR-2024, entry version 110.
DE   SubName: Full=Regulator {ECO:0000313|EMBL:CAE42506.1};
GN   OrderedLocusNames=BP2230 {ECO:0000313|EMBL:CAE42506.1};
OS   Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251).
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Alcaligenaceae; Bordetella.
OX   NCBI_TaxID=257313 {ECO:0000313|EMBL:CAE42506.1, ECO:0000313|Proteomes:UP000002676};
RN   [1] {ECO:0000313|Proteomes:UP000002676}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tohama I / ATCC BAA-589 / NCTC 13251
RC   {ECO:0000313|Proteomes:UP000002676};
RX   PubMed=12910271; DOI=10.1038/ng1227;
RA   Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R.,
RA   Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L.,
RA   Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A.,
RA   Achtman M., Atkin R., Baker S., Basham D., Bason N., Cherevach I.,
RA   Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T.,
RA   Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S.,
RA   Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E.,
RA   Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M.,
RA   Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S.,
RA   Barrell B.G., Maskell D.J.;
RT   "Comparative analysis of the genome sequences of Bordetella pertussis,
RT   Bordetella parapertussis and Bordetella bronchiseptica.";
RL   Nat. Genet. 35:32-40(2003).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; BX640417; CAE42506.1; -; Genomic_DNA.
DR   RefSeq; NP_880874.1; NC_002929.2.
DR   RefSeq; WP_010930809.1; NZ_CP039022.1.
DR   AlphaFoldDB; Q7VWI8; -.
DR   STRING; 257313.BP2230; -.
DR   PaxDb; 257313-BP2230; -.
DR   GeneID; 69602128; -.
DR   KEGG; bpe:BP2230; -.
DR   PATRIC; fig|257313.5.peg.2407; -.
DR   eggNOG; COG2208; Bacteria.
DR   eggNOG; COG2972; Bacteria.
DR   HOGENOM; CLU_020306_1_0_4; -.
DR   Proteomes; UP000002676; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd06225; HAMP; 1.
DR   CDD; cd18774; PDC2_HK_sensor; 2.
DR   Gene3D; 6.10.340.10; -; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 1.
DR   Gene3D; 3.60.40.10; PPM-type phosphatase domain; 1.
DR   InterPro; IPR004010; Double_Cache_2.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR036457; PPM-type-like_dom_sf.
DR   InterPro; IPR001932; PPM-type_phosphatase-like_dom.
DR   InterPro; IPR033480; sCache_2.
DR   PANTHER; PTHR43156:SF2; MULTIDOMAIN REGULATORY PROTEIN RV1364C; 1.
DR   PANTHER; PTHR43156; STAGE II SPORULATION PROTEIN E-RELATED; 1.
DR   Pfam; PF08269; dCache_2; 1.
DR   Pfam; PF00672; HAMP; 1.
DR   Pfam; PF07228; SpoIIE; 1.
DR   SMART; SM01049; Cache_2; 1.
DR   SMART; SM00304; HAMP; 1.
DR   SMART; SM00331; PP2C_SIG; 1.
DR   SUPFAM; SSF158472; HAMP domain-like; 1.
DR   SUPFAM; SSF81606; PP2C-like; 1.
DR   PROSITE; PS50885; HAMP; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002676};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        340..362
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          359..420
FT                   /note="HAMP"
FT                   /evidence="ECO:0000259|PROSITE:PS50885"
SQ   SEQUENCE   673 AA;  73931 MW;  AA5483C8FC85110D CRC64;
     MFMRRTPRLE LPLSLRGKFL LLIASTLLLV GIVVMLVTQR DVTNNIIKNE LHAVSNIMDL
     VVRDTDTRWS TLLDDKIRTI RESRRQLIQL SAVVTSVLNA YAAQAERGHV TTGAAKGMAR
     VWLNHLDLGP RRVAFAYDAE GTVLASTNPR MIDRDLSGIR DFKGRPLAAA MYEESRNDGR
     GFAIYPSPLD ESAQMRHAYF VYFPAWKWVL AISDSSQAII DKVAAQKANM IAAIDRNLSE
     LRLSRHGFVF VVADDGTVIV PPPPSAARLL DSTDVESGRV LHSMLAEISS TRGLTLRFTN
     GESAWQIDAL RYKPLHWTII GVVPEPDLTD PAQNLVRRQA LIFAATLLAG LMLAWVVAVR
     IARPLAQLSN YARQLPTQDL TEPIRVPPSV ACLPRRRRDE VGQLAESFLF MNEQLHHNVR
     ALMAQISNRE RLESELSIAR SIQLGLLPQP LPDAATRGSQ LRAVMYPARE VGGDFYDYFV
     LADGRLCFAI GDVSGKGVPA ALFMAIVRTL IRSVAEEEHD PGAIATKVNH RLAENNPKLM
     FVTLLIGVFT PETGALAWVN AGHPPPLLID ERGEVRLLQG SSGAACGVLD NEAYSTLSTT
     LPNGTSLVAF TDGVTEAIHG GCAQYGLPRL VALMQGAPHA AAELIEHILH DLREFAADSE
     QSDDLTIIAI HRP
//