Reviewed, UniProtKB/Swiss-Prot Q7VWE7 (HEM6_BORPE)

Names and origin

Protein names

Recommended name:
    Coproporphyrinogen 3 oxidase, aerobic
    EC=1.3.3.3
Alternative name(s):
    Coproporphyrinogen III oxidase, aerobic
      Short name=Coproporphyrinogenase
      Short name=Coprogen oxidase

Gene names

Name:	hemF
Ordered Locus Names:	BP2310

Organism

Bordetella pertussis [Complete proteome] [HAMAP]

Taxonomic identifier

520 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length	303 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Coproporphyrinogen-III + O(2) + 2 H(+) = protoporphyrinogen-IX + 2 CO(2) + 2 H(2)O.
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen III (O2 route): step 1/1.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the aerobic coproporphyrinogen III oxidase family.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Cellular component	Cytoplasm
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW porphyrin biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	coproporphyrinogen oxidase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 303	303	Coproporphyrinogen 3 oxidase, aerobic		PRO_0000109885

Sequences

	Sequence		Length	Mass (Da)
	Q7VWE7-1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 6E3F1B2CC136F291	FASTA	303	34,185
	10 20 30 40 50 60 MTAVAIPAVR DYLTDLQGRI VAALEQAGGE AFRTDAWQRA EGGGGVSRLL EGGQLFERAG 70 80 90 100 110 120 VLFSHVKGTR LPPSASAHRP ELAGRGWEAM GVSMVLHPRN PYVPTTHMNV RMFVAAARPG 130 140 150 160 170 180 HAESDVFWFG GGLDLTPYYP FEDDARHFHR ACRDALDPHG ADYYPRYKQW CDEYFFLKHR 190 200 210 220 230 240 NETRGIGGIF FDDLNEPGFD ASFALTCSVG DSFLPAYLPI VQARRDMPYG ERERDFQAYR 250 260 270 280 290 300 RGRYVEFNLV FDRGTLFGLQ SGGRTESILL SMPPLAQWRY DWQPQAGTPE AALAEFLRPR EWV

References

[1]

"Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica." Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S. , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J. Nat. Genet. 35:32-40(2003) [PubMed: 12910271] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tohama I / ATCC BAA-589 / NCTC 13251.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX640418 Genomic DNA. Translation: CAE42583.1.
RefSeq	NP_880948.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2666496.
GenomeReviews	Gene locus BP2310 in contig BX470248_GR.
KEGG	bpe:BP2310.
NMPDR	fig|257313.1.peg.2022.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q7VWE7.
Enzyme and pathway databases
BioCyc	BPER257313:BP2310-MON.
Family and domain databases
HAMAP	MF_00333. [Tree]
InterPro	IPR001260. Coprogen_oxidas. [Graphical view]
Gene3D	G3DSA:3.40.1500.10. Coprogen_oxidas. 1 hit.
PANTHER	PTHR10755. Coprogen_oxidas. 1 hit.
Pfam	PF01218. Coprogen_oxidas. 1 hit. [Graphical view]
PIRSF	PIRSF000166. Coproporphyri_ox. 1 hit.
PRINTS	PR00073. COPRGNOXDASE.
PROSITE	PS01021. COPROGEN_OXIDASE. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
LinkHub	Q7VWE7.

Entry information

Entry name

HEM6_BORPE

Accession

Primary (citable) accession number: Q7VWE7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	October 1, 2003
Last modified:	November 4, 2008
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)