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Q7VW39 (RNC_BORPE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonuclease 3

EC=3.1.26.3
Alternative name(s):
Ribonuclease III
Short name=RNase III
Gene names
Name:rnc
Ordered Locus Names:BP2431
OrganismBordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251) [Reference proteome] [HAMAP]
Taxonomic identifier257313 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella

Protein attributes

Sequence length256 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon By similarity. HAMAP-Rule MF_00104

Catalytic activity

Endonucleolytic cleavage to 5'-phosphomonoester. HAMAP-Rule MF_00104

Cofactor

Mg2+ By similarity. HAMAP-Rule MF_00104

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00104

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00104.

Sequence similarities

Contains 1 DRBM (double-stranded RNA-binding) domain.

Contains 1 RNase III domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 256256Ribonuclease 3 HAMAP-Rule MF_00104
PRO_0000228507

Regions

Domain6 – 128123RNase III
Domain155 – 22571DRBM

Sites

Active site451 Potential
Active site1171 By similarity
Metal binding411Magnesium By similarity
Metal binding1141Magnesium By similarity
Metal binding1171Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7VW39 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 36B8A148A035A807

FASTA25627,829
        10         20         30         40         50         60 
MTAMSLATLE TRLDHRFGDK ALLEQALTHR SHGARHNERL EFLGDSVLNF VVAAMLFERY 

        70         80         90        100        110        120 
GKLDEGDLSR LRANLVKQAS LADIAQRLDL SQYLRLGEGE LKSGGFRRPS ILADTVEALF 

       130        140        150        160        170        180 
GAVFLDAGFE AARRVIVRQY QPVMAHVDPK TLGKDAKTLL QEFLQGRKLA LPQYTVVATH 

       190        200        210        220        230        240 
GAAHSQQFEV ECAIPALEIK IVAPGASRRA AEQSAAKVAL EAAQAVLPAA RAARKSGKAR 

       250 
KTAQLSLPVA VAQEVK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX640418 Genomic DNA. Translation: CAE42703.1.
RefSeqNP_881059.1. NC_002929.2.

3D structure databases

ProteinModelPortalQ7VW39.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING257313.BP2431.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE42703; CAE42703; BP2431.
GeneID2665868.
KEGGbpe:BP2431.
PATRIC21158278. VBIBorPer7866_2621.

Phylogenomic databases

eggNOGCOG0571.
HOGENOMHOG000246809.
KOK03685.
OMATFKDQEL.
OrthoDBEOG6T1WVS.

Enzyme and pathway databases

BioCycBPER257313:BP2431-MONOMER.

Family and domain databases

Gene3D1.10.1520.10. 1 hit.
3.30.160.20. 1 hit.
HAMAPMF_00104. RNase_III.
InterProIPR014720. dsRNA-bd_dom.
IPR011907. RNase_III.
IPR000999. RNase_III_dom.
[Graphical view]
PANTHERPTHR11207. PTHR11207. 1 hit.
PfamPF00035. dsrm. 1 hit.
PF14622. Ribonucleas_3_3. 1 hit.
[Graphical view]
SMARTSM00358. DSRM. 1 hit.
SM00535. RIBOc. 1 hit.
[Graphical view]
SUPFAMSSF69065. SSF69065. 1 hit.
TIGRFAMsTIGR02191. RNaseIII. 1 hit.
PROSITEPS50137. DS_RBD. 1 hit.
PS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRNC_BORPE
AccessionPrimary (citable) accession number: Q7VW39
Entry history
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: October 1, 2003
Last modified: May 14, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families