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Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseImported
Biological processGlyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation
LigandManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:icdImported
Ordered Locus Names:BP2488Imported
OrganismiBordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)Imported
Taxonomic identifieri257313 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
Proteomesi
  • UP000002676 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi257313.BP2488.

Structurei

3D structure databases

ProteinModelPortaliQ7VVZ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 414Iso_dhInterPro annotationAdd BLAST385

Phylogenomic databases

eggNOGiENOG4108HMX. Bacteria.
COG0538. LUCA.
HOGENOMiHOG000021113.
KOiK00031.
OMAiFQQIQTR.

Family and domain databases

InterProiView protein in InterPro
IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
PANTHERiPTHR43504. PTHR43504. 1 hit.
PfamiView protein in Pfam
PF00180. Iso_dh. 1 hit.
SMARTiView protein in SMART
SM01329. Iso_dh. 1 hit.
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiView protein in PROSITE
PS00470. IDH_IMDH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7VVZ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYQHIKVPT GGQKITVNAD YSLNVPDQVI IPVIEGDGTG ADITPVMIKV
60 70 80 90 100
VDAAVQKAYA GKRKIHWMEV YAGEKATKVY GPDVWLPEET LDAVKDYVVS
110 120 130 140 150
IKGPLTTPVG GGIRSLNVAL RQQLDLYVCL RPVRYFKGVP SPVREPEKTD
160 170 180 190 200
MVIFRENSED IYAGIEYMAE SEQAKDLIQY LQTKLGVTKI RFPNTSSIGI
210 220 230 240 250
KPVSREGTER LVRKALQYAI DNDRASVTLV HKGNIMKFTE GGFRDWGYAL
260 270 280 290 300
AQNEFGAQPI DGGPWCKFKN PKTGREIIVK DSIADAFLQQ ILLRPAEYDV
310 320 330 340 350
IATLNLNGDY ISDALAAQVG GIGIAPGANL SDSVAMFEAT HGTAPKYAGK
360 370 380 390 400
DYVNPGSEIL SAEMMLRHMG WTEAADLIIA SMEKSILSKK VTYDFARLLE
410
GATQVSCSGF GQVMIDNM
Length:418
Mass (Da):45,794
Last modified:October 1, 2003 - v1
Checksum:i426D99B735096907
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640418 Genomic DNA. Translation: CAE42760.1.
RefSeqiNP_881115.1. NC_002929.2.
WP_003814059.1. NC_002929.2.

Genome annotation databases

EnsemblBacteriaiCAE42760; CAE42760; BP2488.
GeneIDi2666686.
KEGGibpe:BP2488.
PATRICifig|257313.5.peg.2684.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ7VVZ2_BORPE
AccessioniPrimary (citable) accession number: Q7VVZ2
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: June 7, 2017
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported