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Q7VVZ2

- Q7VVZ2_BORPE

UniProt

Q7VVZ2 - Q7VVZ2_BORPE

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Protein
Isocitrate dehydrogenase [NADP]
Gene
icd, BP2488
Organism
Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  3. magnesium ion binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciBPER257313:BP2488-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:icdImported
Ordered Locus Names:BP2488Imported
OrganismiBordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Taxonomic identifieri257313 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
ProteomesiUP000002676: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi257313.BP2488.

Structurei

3D structure databases

ProteinModelPortaliQ7VVZ2.
SMRiQ7VVZ2. Positions 6-418.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000021113.
KOiK00031.
OMAiRYAIDND.
OrthoDBiEOG6SNDTP.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7VVZ2-1 [UniParc]FASTAAdd to Basket

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MSYQHIKVPT GGQKITVNAD YSLNVPDQVI IPVIEGDGTG ADITPVMIKV    50
VDAAVQKAYA GKRKIHWMEV YAGEKATKVY GPDVWLPEET LDAVKDYVVS 100
IKGPLTTPVG GGIRSLNVAL RQQLDLYVCL RPVRYFKGVP SPVREPEKTD 150
MVIFRENSED IYAGIEYMAE SEQAKDLIQY LQTKLGVTKI RFPNTSSIGI 200
KPVSREGTER LVRKALQYAI DNDRASVTLV HKGNIMKFTE GGFRDWGYAL 250
AQNEFGAQPI DGGPWCKFKN PKTGREIIVK DSIADAFLQQ ILLRPAEYDV 300
IATLNLNGDY ISDALAAQVG GIGIAPGANL SDSVAMFEAT HGTAPKYAGK 350
DYVNPGSEIL SAEMMLRHMG WTEAADLIIA SMEKSILSKK VTYDFARLLE 400
GATQVSCSGF GQVMIDNM 418
Length:418
Mass (Da):45,794
Last modified:October 1, 2003 - v1
Checksum:i426D99B735096907
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX640418 Genomic DNA. Translation: CAE42760.1.
RefSeqiNP_881115.1. NC_002929.2.

Genome annotation databases

EnsemblBacteriaiCAE42760; CAE42760; BP2488.
GeneIDi2666686.
KEGGibpe:BP2488.
PATRICi21158406. VBIBorPer7866_2684.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX640418 Genomic DNA. Translation: CAE42760.1 .
RefSeqi NP_881115.1. NC_002929.2.

3D structure databases

ProteinModelPortali Q7VVZ2.
SMRi Q7VVZ2. Positions 6-418.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257313.BP2488.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE42760 ; CAE42760 ; BP2488 .
GeneIDi 2666686.
KEGGi bpe:BP2488.
PATRICi 21158406. VBIBorPer7866_2684.

Phylogenomic databases

HOGENOMi HOG000021113.
KOi K00031.
OMAi RYAIDND.
OrthoDBi EOG6SNDTP.

Enzyme and pathway databases

BioCyci BPER257313:BP2488-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica."
    Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S.
    , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J.
    Nat. Genet. 35:32-40(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tohama I / ATCC BAA-589 / NCTC 13251.

Entry informationi

Entry nameiQ7VVZ2_BORPE
AccessioniPrimary (citable) accession number: Q7VVZ2
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: May 14, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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