Q7VVX8 (HEMH_BORPE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ferrochelatase
EC=4.99.1.1

Alternative name(s):
Heme synthase
Protoheme ferro-lyase

Gene names

Name:	hemH
Ordered Locus Names:	BP2503

Organism

Bordetella pertussis

Taxonomic identifier

520 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length	362 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323
Catalytic activity	Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323
Pathway	Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323
Subcellular location	Cytoplasm By similarity HAMAP MF_00323.
Sequence similarities	Belongs to the ferrochelatase family.
Sequence caution	The sequence CAE42775.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Heme biosynthesis Porphyrin biosynthesis
Cellular component	Cytoplasm
Ligand	Iron Metal-binding
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	heme biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ferrochelatase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 362	362	Ferrochelatase HAMAP MF_00323		PRO_0000175118
Sites
	Metal binding	228	1	Iron By similarity
	Metal binding	309	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7VVX8 [UniParc]. Last modified February 1, 2005. Version 2. Checksum: 7B0D7E02E8AA4E69	FASTA	362	40,920
	10 20 30 40 50 60 MFLRLFKYLW PERYLPETPA QDPFDENPPP CGPGRVGVLL VNLGTPDEPT RGAIRRYLGE 70 80 90 100 110 120 FLSDPRVIEI PRYLWMPILH GLVLTMRPKK LAPRYAGIWM EEGSPLLVYS QRQAAGVRQG 130 140 150 160 170 180 LAARGVHAEV ELAMRYGKPS IPAAITALRE RGCDHILAVP LYPQYAASTT ATVVDAVTRH 190 200 210 220 230 240 AGRLRDQPAL RFVKRFHNDP AYVEAQAGRI AEFWQAHGRP QKLVMSFHGL PRYSIELGDP 250 260 270 280 290 300 YYRDCLDTAR LLRERLGLRE DEVEVTFQSR FGSARWLEPY TEPTLAELAR QGVTEVDVVC 310 320 330 340 350 360 PGFVADCLET LEEISQECRD AFVAAGGRQF RYIPALNDCP PWIEGLTDLV ERQLRGWPTG NP

References

[1]

"Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica." Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S. , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J. Nat. Genet. 35:32-40(2003) [PubMed: 12910271] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tohama I / ATCC BAA-589 / NCTC 13251.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX640418 Genomic DNA. Translation: CAE42775.1. Different initiation.
3D structure databases
ProteinModelPortal	Q7VVX8.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GenomeReviews	Gene locus BP2503 in contig BX470248_GR.
KEGG	bpe:BP2503.
NMPDR	fig|257313.1.peg.2204.
PATRIC	21158440. VBIBorPer7866_2701.
Phylogenomic databases
HOGENOM	HBG697135.
PhylomeDB	Q7VVX8.
ProtClustDB	PRK00035.
Enzyme and pathway databases
BioCyc	BPER257313:BP2503-MONOMER.
Family and domain databases
HAMAP	MF_00323. Ferrochelatase. [Tree]
InterPro	IPR001015. Ferrochelatase. IPR019772. Ferrochelatase_AS. [Graphical view]
KO	K01772.
PANTHER	PTHR11108. Ferrochelatase. 1 hit.
Pfam	PF00762. Ferrochelatase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00109. HemH. 1 hit.
PROSITE	PS00534. FERROCHELATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HEMH_BORPE

Accession

Primary (citable) accession number: Q7VVX8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	February 1, 2005
Last modified:	January 25, 2012
This is version 52 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program