Reviewed, UniProtKB/Swiss-Prot Q7VV87 (DXS_BORPE)

Names and origin

Protein names

Recommended name:
    1-deoxy-D-xylulose-5-phosphate synthase
    EC=2.2.1.7
Alternative name(s):
    1-deoxyxylulose-5-phosphate synthase
      Short name=DXP synthase
      Short name=DXPS

Gene names

Name:	dxs
Ordered Locus Names:	BP2798

Organism

Bordetella pertussis [Complete proteome] [HAMAP]

Taxonomic identifier

520 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length	620 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity.
Catalytic activity	Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP MF_00315
Cofactor	Binds 1 thiamine pyrophosphate per subunit By similarity.
Pathway	Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP MF_00315
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the transketolase family. DXPS subfamily.

Ontologies

Keywords
Biological process	Isoprene biosynthesis Thiamine biosynthesis
Ligand	Thiamine pyrophosphate
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	terpenoid biosynthetic process Inferred from electronic annotation. Source: HAMAP thiamin biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	1-deoxy-D-xylulose-5-phosphate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 620	620	1-deoxy-D-xylulose-5-phosphate synthase HAMAP MF_00315		PRO_0000189090

Sequences

	Sequence		Length	Mass (Da)
	Q7VV87-1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 4B561873485082A4	FASTA	620	66,261
	10 20 30 40 50 60 MTTELLDRIL SPADLRQLDR RELKRLADEL RGFVLESVSR TGGHLSSNLG TVELSLALHY 70 80 90 100 110 120 VFDTPHDRIV WDVGHQSYPH KILTGRREGM AHLRQQGGIS GFPKRSESEY DAFGTAHSST 130 140 150 160 170 180 SISAALGMAV ASRNAGVQRQ HIAVIGDGAM SAGMAFEAMN NAGVTPNINL LVVLNDNDMS 190 200 210 220 230 240 ISPPVGALNR YLARLMSGQF YAAAKNVGRA VLQHVPPVLE LARRLEEHAK GMVTPATLFE 250 260 270 280 290 300 EFGFNYVGPI DGHDLDALVP TLQNLRALPG LQFLHVVTRK GQGYKLAEAD PVLYHGPGKF 310 320 330 340 350 360 DPAVGIQQAK APARKTFTQV FGQWLCDMAE RDERLVGITP AMREGSGLVE FEQRFPQRYF 370 380 390 400 410 420 DVGIAEQHAV TFAAGLACEG QKPVVAIYST FLQRGYDQLV HDVALQNLDV TFALDRAGLV 430 440 450 460 470 480 GADGATHAGN YDIAFLRCVP NMVVAAPSDE SEARLLLSTC YEHPGPASVR YPRGAGCGAA 490 500 510 520 530 540 VGEGLATVPL GKGLVRREGR RIAILGFGTL VQAALGAAGQ IDAMVADMRF VKPLDRELVL 550 560 570 580 590 600 ELAARHDALV TVEEAAIMGG AGSAVLETLA EAGVTLPVLQ LGLPDAFIDH GDQAALLAGL 610 620 GLDAAGIERA IRARFGALLA

References

[1]

"Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica." Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S. , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J. Nat. Genet. 35:32-40(2003) [PubMed: 12910271] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tohama I / ATCC BAA-589 / NCTC 13251.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX640419 Genomic DNA. Translation: CAE43071.1.
RefSeq	NP_881398.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2666920.
GenomeReviews	Gene locus BP2798 in contig BX470248_GR.
KEGG	bpe:BP2798.
NMPDR	fig|257313.1.peg.2471.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q7VV87.
OMA	MQELPHP.
Enzyme and pathway databases
BioCyc	BPER257313:BP2798-MON.
BRENDA	2.2.1.7. 21511.
Family and domain databases
HAMAP	MF_00315. [Tree]
InterPro	IPR005477. Dxylulose-5-P_synthase. IPR015941. Transketolase-like_C. IPR005475. Transketolase-like_Pyr-bd. IPR005476. Transketolase_C. IPR005474. Transketolase_N. [Graphical view]
Gene3D	G3DSA:3.40.50.920. Transketo_C_like. 1 hit.
Pfam	PF02779. Transket_pyr. 1 hit. PF02780. Transketolase_C. 1 hit. [Graphical view]
TIGRFAMs	TIGR00204. dxs. 1 hit.
PROSITE	PS00801. TRANSKETOLASE_1. 1 hit. PS00802. TRANSKETOLASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DXS_BORPE

Accession

Primary (citable) accession number: Q7VV87

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	October 1, 2003
Last modified:	November 3, 2009
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)