Reviewed, UniProtKB/Swiss-Prot Q7VUW0 (ARGC_BORPE)

Names and origin

Protein names

Recommended name:
    N-acetyl-gamma-glutamyl-phosphate reductase
      Short name=AGPR
    EC=1.2.1.38
Alternative name(s):
    N-acetyl-glutamate semialdehyde dehydrogenase
      Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	BP2960

Organism

Bordetella pertussis [Complete proteome] [HAMAP]

Taxonomic identifier

520 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length	354 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: HAMAP NAD or NADH binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 354	354	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150		PRO_0000112390
Sites
	Active site	156	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7VUW0-1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: FB91310A11C6C402	FASTA	354	37,830
	10 20 30 40 50 60 MAQASNSRIK VGIVGGTGYT GVELLRLLSQ HPHVELTAIT SRKEDGLPVA DMYPNLRGRV 70 80 90 100 110 120 KLAFSAPEKA SLTDCDVVFF ATPHGVAMAQ AAELLAAGTR VIDLAADFRL QDTAVFERWY 130 140 150 160 170 180 KIPHTCPDIL ADSVYGLVEL NREAISKARV IGNPGCYPTT VLLGLAPLIE GGKQLVDVQT 190 200 210 220 230 240 LIADCKSGVS GAGRKAEVGS LFSEASDNFK AYGVAGHRHQ PEIVAQLEKL AGGKVGLTFV 250 260 270 280 290 300 PHLVPMIRGM FSTLYARILP QARDTDFQAL FEARYADEPF VDVMPAGSLP ETRSVRASNN 310 320 330 340 350 LRISVQRPGG GDQLVILVVQ DNLVKGASGQ AVQNMNLMFG LPESAGLDQV AILP

References

[1]

"Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica." Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S. , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J. Nat. Genet. 35:32-40(2003) [PubMed: 12910271] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tohama I / ATCC BAA-589 / NCTC 13251.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX640420 Genomic DNA. Translation: CAE43232.1.
RefSeq	NP_881539.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2665698.
GenomeReviews	Gene locus BP2960 in contig BX470248_GR.
KEGG	bpe:BP2960.
NMPDR	fig|257313.1.peg.2612.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q7VUW0.
OMA	Q7VUW0. VCRIAVH.
Enzyme and pathway databases
BioCyc	BPER257313:BP2960-MON.
BRENDA	1.2.1.38. 21511.
Family and domain databases
HAMAP	MF_00150. [Tree]
InterPro	IPR000706. AGPR_act_site. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_C. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
ProDom	PD003765. AGPR_act_site. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01850. argC. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_BORPE

Accession

Primary (citable) accession number: Q7VUW0

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 2003
Last sequence update:	October 1, 2003
Last modified:	June 16, 2009
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)