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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei242ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBPER257313:G1GSZ-3533-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:BP2978
OrganismiBordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Taxonomic identifieri257313 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
Proteomesi
  • UP000002676 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001195201 – 460Glutamate--tRNA ligaseAdd BLAST460

Proteomic databases

PRIDEiQ7VUU5

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi257313.BP2978

Structurei

3D structure databases

ProteinModelPortaliQ7VUU5
SMRiQ7VUU5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi7 – 17"HIGH" regionUniRule annotationAdd BLAST11
Motifi239 – 243"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252722
KOiK01885
OMAiAYYAFDT

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.8.70, 2 hits
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020752 aa-tRNA-synth_I_codon-bd_sub1
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q7VUU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTRFAPSPT GFLHLGGART ALFSWAFARH HQGVFVLRIE DTDVERSTPE
60 70 80 90 100
AVQAILDSMD WLGMQPDEGP FYQMKRMDRY AEVLAGMLEA GTAYHCYCSP
110 120 130 140 150
EEVDAMREAA RAKGLKPRYD GTWRPEPGKT LPPVPADRKP VIRFRNPIDG
160 170 180 190 200
ATSWNDMVKG PISFDNGELD DLIIARPDGT PTYNFCVVVD DWDMGITHVL
210 220 230 240 250
RGDDHVNNTP RQINILRALG ATLPEYGHVP MILGPDGEKL SKRHGAVNVM
260 270 280 290 300
EYDAQGYLPE AMVNYLARLG WSHGDDELFT REQLVEWFDT RHLSKSASQW
310 320 330 340 350
DPKKLNWVNA HYIKGMDDAE LAGRVAPRVE RRGGKPQAAD LPAIMGLLKD
360 370 380 390 400
RAETLEQLAE DAMLFCGEYQ PAPAELAAQH LTETARAALA DFAARARDTE
410 420 430 440 450
WNRAAISALI KAVLADRGLK MPQLGIPLRV AVTGRAQTPA VDAVLELLGK
460
ETVLARLQAL
Length:460
Mass (Da):51,082
Last modified:October 1, 2003 - v1
Checksum:i3CB1BE13A27FFCBE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640420 Genomic DNA Translation: CAE43249.1
RefSeqiNP_881555.1, NC_002929.2
WP_010931232.1, NC_002929.2

Genome annotation databases

EnsemblBacteriaiCAE43249; CAE43249; BP2978
GeneIDi2666918
KEGGibpe:BP2978
PATRICifig|257313.5.peg.3222

Similar proteinsi

Entry informationi

Entry nameiSYE_BORPE
AccessioniPrimary (citable) accession number: Q7VUU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: October 1, 2003
Last modified: May 23, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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