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Q7VUQ9 (LPXC_BORPE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
EC=3.5.1.-
Alternative name(s):
UDP-3-O-acyl-GlcNAc deacetylase
Gene names
Name:lpxC
Ordered Locus Names:BP3017
OrganismBordetella pertussis
Taxonomic identifier520 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length307 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP MF_00388

Catalytic activity

UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine + H2O = UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine + acetate. HAMAP MF_00388

Pathway

Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 2/6. HAMAP MF_00388

Sequence similarities

Belongs to the LpxC family.

Ontologies

Keywords
   Biological processLipid A biosynthesis
Lipid synthesis
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processlipid A biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionUDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 307307UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase HAMAP MF_00388
PRO_0000253649

Sequences

Sequence LengthMass (Da)Tools
Q7VUQ9 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: C30D9FB015FD4856

FASTA30734,156
        10         20         30         40         50         60 
MFRQRSIQNL VRTIGVGVHS GRRVELTLRP AEANTGIVFH RVDLPQVVDL PASAIGVGDT 

        70         80         90        100        110        120 
RMASVLQQGN VRVSTVEHLM SALAGLGIDN LHVDLTAEEV PIMDGSAATF VYLLRSAGIV 

       130        140        150        160        170        180 
EQNAPKRFIR VLKPIEVREG EGRNEKWARL EPHEGFALAF SIDFRHPAID STANFAEIDF 

       190        200        210        220        230        240 
ATHSYVREIA RARTFGFVNE VEALRSMGLA RGGSLDNAIV MDEFRVLNSD GLRYDDEFVK 

       250        260        270        280        290        300 
HKILDAIGDL YLLGKPLVAR YVAYKSGHAL NNQLARALLE QQDAWELVTY ESQAEAPQAF 


RHEWKLA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX640420 Genomic DNA. Translation: CAE43288.1.
RefSeqNP_881592.1. NC_002929.2.

3D structure databases

HSSPHSSP built from PDB template 1P42 based on UniProtKB O67648.
ProteinModelPortalQ7VUQ9.
SMRQ7VUQ9. Positions 1-297.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2665910.
GenomeReviewsGene locus BP3017 in contig BX470248_GR.
KEGGbpe:BP3017.
PATRIC21159572. VBIBorPer7866_3263.

Phylogenomic databases

HOGENOMHBG482342.
OMAKAYKSGH.
PhylomeDBQ7VUQ9.
ProtClustDBPRK13186.

Enzyme and pathway databases

BioCycBPER257313:BP3017-MONOMER.

Family and domain databases

HAMAPMF_00388. LpxC.
[Tree]
InterProIPR020568. Ribosomal_S5_D2-typ_fold.
IPR004463. UDP-acyl_GlcNac_deAcase.
IPR011334. UDP-acyl_GlcNac_deAcase_C.
IPR015870. UDP-acyl_N-AcGlcN_deAcase_N.
[Graphical view]
Gene3DG3DSA:3.30.1700.10. UDP-acyl_N-AcGlcN_deAcase_C. 1 hit.
G3DSA:3.30.230.20. UDP-acyl_N-AcGlcN_deAcase_N. 1 hit.
KOK02535.
PfamPF03331. LpxC. 1 hit.
[Graphical view]
SUPFAMSSF54211. Ribosomal_S5_D2-typ_fold. 2 hits.
TIGRFAMsTIGR00325. LpxC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLPXC_BORPE
AccessionPrimary (citable) accession number: Q7VUQ9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 1, 2003
Last modified: January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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