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Q7VUG2 (HGD_BORPE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homogentisate 1,2-dioxygenase

EC=1.13.11.5
Alternative name(s):
Homogentisate oxygenase
Homogentisic acid oxidase
Homogentisicase
Gene names
Name:hmgA
Ordered Locus Names:BP3134
OrganismBordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251) [Reference proteome] [HAMAP]
Taxonomic identifier257313 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella

Protein attributes

Sequence length432 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Homogentisate + O2 = 4-maleylacetoacetate. HAMAP-Rule MF_00334

Cofactor

Iron By similarity. HAMAP-Rule MF_00334

Pathway

Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6. HAMAP-Rule MF_00334

Sequence similarities

Belongs to the homogentisate dioxygenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 432432Homogentisate 1,2-dioxygenase HAMAP-Rule MF_00334
PRO_0000225784

Sites

Metal binding3291Iron By similarity
Metal binding3351Iron By similarity
Metal binding3651Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7VUG2 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 518A054ED0EE3F96

FASTA43248,046
        10         20         30         40         50         60 
MSLHYQTGFG NACATEALPG ALPAGRNSPQ ICPYGLYAEQ LSGTAFTAPR AENRRSWLYR 

        70         80         90        100        110        120 
IRPGVQHLPF APFAGAQRWL SDFGRQPVTP NQLRWSPLPM PDAPTDFIDG MHTWGGNGGP 

       130        140        150        160        170        180 
EEQSGVGIHL YAANRSMQGR FFYNADGEML IVPQQGRLRL ATELGLIDIE PYEIAVVPRG 

       190        200        210        220        230        240 
VRLRVELLDD VARGYVLENF GTAMRLPELG PIGSNCLANA RDFQIPVAWY EDVEGDFELI 

       250        260        270        280        290        300 
AKFTGGFWRA PITHSPLNVV AWHGTHAPYK YDLRNFNTVG SISYDHPDPS IFTVLTSPSD 

       310        320        330        340        350        360 
TPGTANMDFA IFPPRILAME NTFRPPWFHR NIASEFMGLI HGVYDAKAEG FAPGGASLHN 

       370        380        390        400        410        420 
CMSGHGPDAD TFEKASHADT SQAHYIRDTM AFMFETRRVI RPTAQALASP QRQDDYYQCW 

       430 
QGLQKHFDPE QA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX640420 Genomic DNA. Translation: CAE43401.1.
RefSeqNP_881699.1. NC_002929.2.

3D structure databases

ProteinModelPortalQ7VUG2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING257313.BP3134.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE43401; CAE43401; BP3134.
GeneID2666382.
KEGGbpe:BP3134.
PATRIC21159828. VBIBorPer7866_3385.

Phylogenomic databases

eggNOGCOG3508.
HOGENOMHOG000139824.
KOK00451.
OMACWEPLKS.
OrthoDBEOG6D5FZK.
ProtClustDBPRK05341.

Enzyme and pathway databases

BioCycBPER257313:BP3134-MONOMER.
UniPathwayUPA00139; UER00339.

Family and domain databases

Gene3D2.60.120.10. 2 hits.
HAMAPMF_00334. Homogentis_dioxygen.
InterProIPR005708. Homogentis_dOase.
IPR022950. Homogentis_dOase_bac.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERPTHR11056. PTHR11056. 1 hit.
PfamPF04209. HgmA. 1 hit.
[Graphical view]
SUPFAMSSF51182. SSF51182. 1 hit.
TIGRFAMsTIGR01015. hmgA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHGD_BORPE
AccessionPrimary (citable) accession number: Q7VUG2
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: October 1, 2003
Last modified: February 19, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways