Reviewed, UniProtKB/Swiss-Prot Q7VUG2 (HGD_BORPE)

Names and origin

Protein names

Recommended name:
    Homogentisate 1,2-dioxygenase
    EC=1.13.11.5
Alternative name(s):
    Homogentisicase
    Homogentisate oxygenase
    Homogentisic acid oxidase

Gene names

Name:	hmgA
Ordered Locus Names:	BP3134

Organism

Bordetella pertussis [Complete proteome] [HAMAP]

Taxonomic identifier

520 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length	432 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Homogentisate + O(2) = 4-maleylacetoacetate.
Cofactor	Iron By similarity.
Pathway	Amino-acid degradation; L-phenylalanine degradation; acetoacetic acid and fumarate from L-phenylalanine: step 4/6.
Sequence similarities	Belongs to the homogentisate dioxygenase family.

Ontologies

Keywords
Biological process	Phenylalanine catabolism Tyrosine catabolism
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	L-phenylalanine catabolic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tyrosine catabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	homogentisate 1,2-dioxygenase activity Inferred from electronic annotation. Source: HAMAP iron ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 432	432	Homogentisate 1,2-dioxygenase		PRO_0000225784
Sites
	Metal binding	329	1	Iron By similarity
	Metal binding	335	1	Iron By similarity
	Metal binding	365	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7VUG2-1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 518A054ED0EE3F96	FASTA	432	48,046
	10 20 30 40 50 60 MSLHYQTGFG NACATEALPG ALPAGRNSPQ ICPYGLYAEQ LSGTAFTAPR AENRRSWLYR 70 80 90 100 110 120 IRPGVQHLPF APFAGAQRWL SDFGRQPVTP NQLRWSPLPM PDAPTDFIDG MHTWGGNGGP 130 140 150 160 170 180 EEQSGVGIHL YAANRSMQGR FFYNADGEML IVPQQGRLRL ATELGLIDIE PYEIAVVPRG 190 200 210 220 230 240 VRLRVELLDD VARGYVLENF GTAMRLPELG PIGSNCLANA RDFQIPVAWY EDVEGDFELI 250 260 270 280 290 300 AKFTGGFWRA PITHSPLNVV AWHGTHAPYK YDLRNFNTVG SISYDHPDPS IFTVLTSPSD 310 320 330 340 350 360 TPGTANMDFA IFPPRILAME NTFRPPWFHR NIASEFMGLI HGVYDAKAEG FAPGGASLHN 370 380 390 400 410 420 CMSGHGPDAD TFEKASHADT SQAHYIRDTM AFMFETRRVI RPTAQALASP QRQDDYYQCW 430 QGLQKHFDPE QA

References

[1]

"Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica." Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S. , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J. Nat. Genet. 35:32-40(2003) [PubMed: 12910271] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tohama I / ATCC BAA-589 / NCTC 13251.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX640420 Genomic DNA. Translation: CAE43401.1.
RefSeq	NP_881699.1.
3D structure databases
HSSP	HSSP built from PDB template 1EYB based on UniProtKB Q93099.
ModBase	Search...
Genome annotation databases
GeneID	2666382.
GenomeReviews	Gene locus BP3134 in contig BX470248_GR.
KEGG	bpe:BP3134.
NMPDR	fig|257313.1.peg.2771.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q7VUG2.
Enzyme and pathway databases
BioCyc	BPER257313:BP3134-MON.
Family and domain databases
HAMAP	MF_00334. [Tree]
InterPro	IPR005708. Homogentis_dOase. [Graphical view]
PANTHER	PTHR11056. Homogentis_dOase. 1 hit.
Pfam	PF04209. HgmA. 1 hit. [Graphical view]
TIGRFAMs	TIGR01015. hmgA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HGD_BORPE

Accession

Primary (citable) accession number: Q7VUG2

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 7, 2006
Last sequence update:	October 1, 2003
Last modified:	November 4, 2008
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)