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Q7VUE3 (TYSY_BORPE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidylate synthase

Short name=TS
Short name=TSase
EC=2.1.1.45
Gene names
Name:thyA
Ordered Locus Names:BP3154
OrganismBordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251) [Reference proteome] [HAMAP]
Taxonomic identifier257313 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella

Protein attributes

Sequence length323 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Provides the sole de novo source of dTMP for DNA biosynthesis By similarity. HAMAP-Rule MF_00008

Catalytic activity

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP. HAMAP-Rule MF_00008

Pathway

Pyrimidine metabolism; dTTP biosynthesis. HAMAP-Rule MF_00008

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00008

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00008.

Sequence similarities

Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.

Ontologies

Keywords
   Biological processNucleotide biosynthesis
   Cellular componentCytoplasm
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdTMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

dTTP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionthymidylate synthase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 323323Thymidylate synthase HAMAP-Rule MF_00008
PRO_0000140940

Sites

Active site1921 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7VUE3 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 79BD4F55966B52AC

FASTA32336,370
        10         20         30         40         50         60 
MKQYLDLVQS ILDQGAWQEN RTGVRTLSLP GAALRFDLQQ GFPAVTTKKL AFKSAIGEMV 

        70         80         90        100        110        120 
GFLRATRSAA QFRALGCKVW DQNANENEQW LANPYREGPD DLGPVYGVQW RHWPAYKLLP 

       130        140        150        160        170        180 
SSAGGQVADA LARGYRQVAE VDENGAPHVL LYKAVDQLRQ CLDTIRQSPG DRRILFHGWN 

       190        200        210        220        230        240 
WAQIEEMALP PCHLLYQFLP NAGTREISLC LYIRSNDVGL GTPFNLTEGA ALLHLVGRLT 

       250        260        270        280        290        300 
GYKPRWFSYF IGDAHVYENH LPMLREQLAR EPYPAPQLVL SDRIPDFAVT GKYEPQWLEQ 

       310        320 
VEPGDFTLSG YQHHAPLTAP MAV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX640420 Genomic DNA. Translation: CAE43421.1.
RefSeqNP_881719.1. NC_002929.2.

3D structure databases

ProteinModelPortalQ7VUE3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING257313.BP3154.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE43421; CAE43421; BP3154.
GeneID2665560.
KEGGbpe:BP3154.
PATRIC21159868. VBIBorPer7866_3405.

Phylogenomic databases

eggNOGCOG0207.
HOGENOMHOG000257900.
KOK00560.
OMANLGPVYG.
OrthoDBEOG6K6V53.
ProtClustDBPRK13821.

Enzyme and pathway databases

BioCycBPER257313:BP3154-MONOMER.
UniPathwayUPA00575.

Family and domain databases

Gene3D3.30.572.10. 1 hit.
HAMAPMF_00008. Thymidy_synth_bact.
InterProIPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view]
PfamPF00303. Thymidylat_synt. 1 hit.
[Graphical view]
PRINTSPR00108. THYMDSNTHASE.
SUPFAMSSF55831. SSF55831. 2 hits.
TIGRFAMsTIGR03284. thym_sym. 1 hit.
PROSITEPS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTYSY_BORPE
AccessionPrimary (citable) accession number: Q7VUE3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: October 1, 2003
Last modified: February 19, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways