Q7VU58 (DSBC_BORPE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable thiol:disulfide interchange protein DsbC

Gene names

Name:	dsbC
Ordered Locus Names:	BP3270

Organism

Bordetella pertussis

Taxonomic identifier

520 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length	279 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process By similarity. Necessary for extracellular secretion of the pertussis toxin (PTX). Ref.2
Subcellular location	Periplasm By similarity.
Sequence similarities	Belongs to the thioredoxin family. DsbC subfamily.

Ontologies

Keywords
Cellular component	Periplasm
Domain	Redox-active center Signal
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro
Cellular component	periplasmic space Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 31	31	Potential
	Chain	32 – 279	248	Probable thiol:disulfide interchange protein DsbC		PRO_0000245645
Amino acid modifications
	Disulfide bond	174 ↔ 177		Redox-active By similarity
	Disulfide bond	213 ↔ 236		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7VU58 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: A18134861A5F13AD	FASTA	279	30,659
	10 20 30 40 50 60 MSGPSFSGAG MNFRITVWCA AAAVWSSGAL AQDGAGQAAP GTPDKVYSTT GSAPAKPGDK 70 80 90 100 110 120 VYSTRSAQAP DPQADAVKER FAQRFEGFDV TAVRRTPYGL FEVQIGTDLL YTDEKVTWVM 130 140 150 160 170 180 EGPLIDALTR RDVTRERQEK LSSVPFEELP LDLAVKQVKG DGSRVMAVFE DPNCGYCKQL 190 200 210 220 230 240 HRTLEDMDNI TVYTFLYPIL SPDSTTKVRD IWCASDPAKV WKDWMVRGQR PPTAECDAPV 250 260 270 DQWLALGRQL MVRGTPAIFF KSGGRVSGAL PRDELEARL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica." Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S. , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J. Nat. Genet. 35:32-40(2003) [PubMed: 12910271] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tohama I / ATCC BAA-589 / NCTC 13251.
[2]	"DsbA and DsbC are required for secretion of pertussis toxin by Bordetella pertussis." Stenson T.H., Weiss A.A. Infect. Immun. 70:2297-2303(2002) [PubMed: 11953363] [Abstract] Cited for: FUNCTION IN PERTUSSIS TOXIN SECRETION. Strain: Tohama I / BP338.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX640421 Genomic DNA. Translation: CAE43536.1.
RefSeq	NP_881814.1. NC_002929.2.
3D structure databases
ProteinModelPortal	Q7VU58.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2667482.
GenomeReviews	Gene locus BP3270 in contig BX470248_GR.
KEGG	bpe:BP3270.
NMPDR	fig|257313.1.peg.2885.
PATRIC	21160140. VBIBorPer7866_3541.
Phylogenomic databases
HOGENOM	HBG469935.
OMA	MNGLYEI.
PhylomeDB	Q7VU58.
ProtClustDB	CLSK921008.
Enzyme and pathway databases
BioCyc	BPER257313:BP3270-MONOMER.
Family and domain databases
InterPro	IPR018950. DiS-bond_isomerase_DsbC/G_N. IPR009094. DiS-bond_isomerase_DsbC_N. IPR012336. Thioredoxin-like_fold. IPR017937. Thioredoxin_CS. [Graphical view]
Gene3D	G3DSA:3.10.450.70. Disulf_isomers_N. 1 hit. G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
KO	K03981.
Pfam	PF10411. DsbC_N. 1 hit. [Graphical view]
SUPFAM	SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS00194. THIOREDOXIN_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DSBC_BORPE

Accession

Primary (citable) accession number: Q7VU58

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2006
Last sequence update:	October 1, 2003
Last modified:	January 25, 2012
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program