Q7VU41 (DCUP_BORPE) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 54.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Uroporphyrinogen decarboxylase Short name=UPD Short name=URO-D EC=4.1.1.37 | ||||
| Gene names |
| ||||
| Organism | Bordetella pertussis | ||||
| Taxonomic identifier | 520 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella |
Protein attributes
| Sequence length | 358 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity. HAMAP MF_00218 |
| Catalytic activity | Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218 |
| Pathway | Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218 |
| Subunit structure | Homodimer By similarity. HAMAP MF_00218 |
| Subcellular location | Cytoplasm Probable HAMAP MF_00218. |
| Sequence similarities | Belongs to the uroporphyrinogen decarboxylase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Porphyrin biosynthesis |
| Cellular component | Cytoplasm |
| Molecular function | Decarboxylase Lyase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | porphyrin-containing compound biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | uroporphyrinogen decarboxylase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 358 | 358 | Uroporphyrinogen decarboxylase HAMAP MF_00218 | PRO_0000187587 | |||||
Regions | |||||||||
| Region | 29 – 33 | 5 | Substrate binding By similarity | ||||||
Sites | |||||||||
| Binding site | 48 | 1 | Substrate By similarity | ||||||
| Binding site | 79 | 1 | Substrate By similarity | ||||||
| Binding site | 155 | 1 | Substrate By similarity | ||||||
| Binding site | 210 | 1 | Substrate By similarity | ||||||
| Binding site | 330 | 1 | Substrate By similarity | ||||||
| Site | 79 | 1 | Transition state stabilizer By similarity | ||||||
Sequences
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References
| [1] | "Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica." Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S. Maskell D.J.Nat. Genet. 35:32-40(2003) [PubMed: 12910271] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tohama I / ATCC BAA-589 / NCTC 13251. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BX640421 Genomic DNA. Translation: CAE43556.1. |
| RefSeq | NP_881833.1. NC_002929.2. |
3D structure databases | |
| ProteinModelPortal | Q7VU41. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 2667375. |
| GenomeReviews | Gene locus BP3291 in contig BX470248_GR. |
| KEGG | bpe:BP3291. |
| NMPDR | fig|257313.1.peg.2904. |
| PATRIC | 21160184. VBIBorPer7866_3563. |
Phylogenomic databases | |
| HOGENOM | HBG628392. |
| OMA | PRIHFGV. |
| PhylomeDB | Q7VU41. |
| ProtClustDB | PRK00115. |
Enzyme and pathway databases | |
| BioCyc | BPER257313:BP3291-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00218. URO-D. [Tree] |
| InterPro | IPR006361. Uroporphyrinogen_deCO2ase_HemE. IPR000257. Uroporphyrinogen_deCOase. [Graphical view] |
| KO | K01599. |
| PANTHER | PTHR21091:SF2. HemE. 1 hit. |
| Pfam | PF01208. URO-D. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01464. HemE. 1 hit. |
| PROSITE | PS00906. UROD_1. 1 hit. PS00907. UROD_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | DCUP_BORPE | ||||||||
| Accession | Primary (citable) accession number: Q7VU41 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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