Reviewed, UniProtKB/Swiss-Prot Q7VU41 (DCUP_BORPE)

Names and origin

Protein names

Recommended name:
    Uroporphyrinogen decarboxylase
      Short name=URO-D
      Short name=UPD
    EC=4.1.1.37

Gene names

Name:	hemE
Ordered Locus Names:	BP3291

Organism

Bordetella pertussis [Complete proteome] [HAMAP]

Taxonomic identifier

520 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length	358 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity.
Catalytic activity	Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the uroporphyrinogen decarboxylase family.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Cellular component	Cytoplasm
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	porphyrin biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	uroporphyrinogen decarboxylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 358	358	Uroporphyrinogen decarboxylase HAMAP MF_00218		PRO_0000187587
Regions
	Region	29 – 33	5	Substrate binding By similarity
Sites
	Binding site	48	1	Substrate By similarity
	Binding site	79	1	Substrate By similarity
	Binding site	155	1	Substrate By similarity
	Binding site	210	1	Substrate By similarity
	Binding site	330	1	Substrate By similarity
	Site	79	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7VU41-1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: F0718A07C21C502F	FASTA	358	39,270
	10 20 30 40 50 60 MSVAPLKNDV FLRALLREPV PYTPIWLMRQ AGRYLPEYNA TRARAGSFMG LAQNPDYACE 70 80 90 100 110 120 VTLQPLARYP LDAAILFSDI LTVPHAMGLG LDFAPGEGPR FAHPVRDESD VAKLAVPDMD 130 140 150 160 170 180 SLRYVFDAVR TIRRELDGRV PLIGFAGSPW TIACYMAEGR GSDDYRLIKS MLYGRPDLLH 190 200 210 220 230 240 RILEINAEAT RHYLNAQIDA GAQAVMLFDS WGGVLADGLF QQFSLAYTRR VVEGLTRERE 250 260 270 280 290 300 GRRVPVIVFT KGGGQWLEEI AACGCDAVGL DWTVNLGAAR RRVTDAVALQ GNLDPMTLFG 310 320 330 340 350 GAQAVRAEAR RTLDAFGPVG KGGHVFNLGH GISQYSPPEV VSELVDEVHT YSRALHAG

References

[1]

"Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica." Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S. , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J. Nat. Genet. 35:32-40(2003) [PubMed: 12910271] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tohama I / ATCC BAA-589 / NCTC 13251.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX640421 Genomic DNA. Translation: CAE43556.1.
RefSeq	NP_881833.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2667375.
GenomeReviews	Gene locus BP3291 in contig BX470248_GR.
KEGG	bpe:BP3291.
NMPDR	fig|257313.1.peg.2904.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q7VU41.
OMA	VFTKGGG.
Enzyme and pathway databases
BioCyc	BPER257313:BP3291-MON.
BRENDA	4.1.1.37. 21511.
Family and domain databases
HAMAP	MF_00218. [Tree]
InterPro	IPR006361. Uroporphyrinogen_deCO2ase_HemE. IPR000257. Uroporphyrinogen_deCOase. [Graphical view]
PANTHER	PTHR21091:SF2. HemE. 1 hit.
Pfam	PF01208. URO-D. 1 hit. [Graphical view]
ProDom	PD003225. Uro_decarbxyls. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01464. hemE. 1 hit.
PROSITE	PS00906. UROD_1. 1 hit. PS00907. UROD_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DCUP_BORPE

Accession

Primary (citable) accession number: Q7VU41

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2004
Last sequence update:	October 1, 2003
Last modified:	November 3, 2009
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)