Reviewed,
UniProtKB/Swiss-Prot Q7VU41 (DCUP_BORPE)
Last modified
November 3, 2009.
Version 40.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Uroporphyrinogen decarboxylase Short name=URO-D Short name=UPD EC=4.1.1.37 | ||||
| Gene names |
| ||||
| Organism | Bordetella pertussis [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 520 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella |
Protein attributes
| Sequence length | 358 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity. |
| Catalytic activity | Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218 |
| Pathway | Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218 |
| Subunit structure | Homodimer By similarity. |
| Subcellular location | Cytoplasm Probable. |
| Sequence similarities | Belongs to the uroporphyrinogen decarboxylase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Porphyrin biosynthesis |
| Cellular component | Cytoplasm |
| Molecular function | Decarboxylase Lyase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | porphyrin biosynthetic process Inferred from electronic annotation. Source: HAMAP |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | uroporphyrinogen decarboxylase activity Inferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 358 | 358 | Uroporphyrinogen decarboxylase HAMAP MF_00218 | PRO_0000187587 | |||||
Regions | |||||||||
| Region | 29 – 33 | 5 | Substrate binding By similarity | ||||||
Sites | |||||||||
| Binding site | 48 | 1 | Substrate By similarity | ||||||
| Binding site | 79 | 1 | Substrate By similarity | ||||||
| Binding site | 155 | 1 | Substrate By similarity | ||||||
| Binding site | 210 | 1 | Substrate By similarity | ||||||
| Binding site | 330 | 1 | Substrate By similarity | ||||||
| Site | 79 | 1 | Transition state stabilizer By similarity | ||||||
Sequences
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References
| [1] | "Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica." Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S. Maskell D.J.Nat. Genet. 35:32-40(2003) [PubMed: 12910271] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tohama I / ATCC BAA-589 / NCTC 13251. |
Cross-references
Sequence databases | |
|---|---|
| BX640421 Genomic DNA. Translation: CAE43556.1. | |
| RefSeq | NP_881833.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 2667375. |
| GenomeReviews | Gene locus BP3291 in contig BX470248_GR. |
| KEGG | bpe:BP3291. |
| NMPDR | fig|257313.1.peg.2904. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | Q7VU41. |
| OMA | VFTKGGG. |
Enzyme and pathway databases | |
| BioCyc | BPER257313:BP3291-MON. |
| BRENDA | 4.1.1.37. 21511. |
Family and domain databases | |
| HAMAP | MF_00218. [Tree] |
| InterPro | IPR006361. Uroporphyrinogen_deCO2ase_HemE. IPR000257. Uroporphyrinogen_deCOase. [Graphical view] |
| PANTHER | PTHR21091:SF2. HemE. 1 hit. |
| Pfam | PF01208. URO-D. 1 hit. [Graphical view] |
| ProDom | PD003225. Uro_decarbxyls. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| TIGRFAMs | TIGR01464. hemE. 1 hit. |
| PROSITE | PS00906. UROD_1. 1 hit. PS00907. UROD_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | DCUP_BORPE | ||||||||
| Accession | Primary (citable) accession number: Q7VU41 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


