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Protein

Argininosuccinate synthase

Gene

argG

Organism
Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ornithine carbamoyltransferase (argF)
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei43ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1
Binding sitei99CitrullineUniRule annotation1
Binding sitei129ATP; via amide nitrogenUniRule annotation1
Binding sitei131AspartateUniRule annotation1
Binding sitei131ATPUniRule annotation1
Binding sitei135AspartateUniRule annotation1
Binding sitei135CitrullineUniRule annotation1
Binding sitei136AspartateUniRule annotation1
Binding sitei136ATPUniRule annotation1
Binding sitei139CitrullineUniRule annotation1
Binding sitei192CitrullineUniRule annotation1
Binding sitei194ATPUniRule annotation1
Binding sitei201CitrullineUniRule annotation1
Binding sitei203CitrullineUniRule annotation1
Binding sitei280CitrullineUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi17 – 25ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processAmino-acid biosynthesis, Arginine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBPER257313:G1GSZ-4212-MONOMER
UniPathwayiUPA00068; UER00113

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotation
Ordered Locus Names:BP3537
OrganismiBordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Taxonomic identifieri257313 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
Proteomesi
  • UP000002676 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001486921 – 445Argininosuccinate synthaseAdd BLAST445

Proteomic databases

PRIDEiQ7VTJ9

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

STRINGi257313.BP3537

Structurei

Secondary structure

1445
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi12 – 17Combined sources6
Helixi22 – 33Combined sources12
Beta strandi37 – 44Combined sources8
Helixi55 – 62Combined sources8
Beta strandi66 – 72Combined sources7
Helixi74 – 86Combined sources13
Beta strandi92 – 94Combined sources3
Beta strandi97 – 99Combined sources3
Helixi102 – 120Combined sources19
Beta strandi125 – 127Combined sources3
Helixi136 – 147Combined sources12
Beta strandi152 – 154Combined sources3
Helixi156 – 158Combined sources3
Helixi160 – 165Combined sources6
Helixi169 – 178Combined sources10
Beta strandi190 – 195Combined sources6
Beta strandi200 – 204Combined sources5
Helixi205 – 208Combined sources4
Helixi214 – 216Combined sources3
Beta strandi220 – 222Combined sources3
Beta strandi235 – 242Combined sources8
Beta strandi245 – 249Combined sources5
Helixi257 – 269Combined sources13
Turni270 – 274Combined sources5
Beta strandi276 – 281Combined sources6
Beta strandi287 – 293Combined sources7
Helixi295 – 311Combined sources17
Helixi314 – 333Combined sources20
Helixi339 – 351Combined sources13
Helixi353 – 355Combined sources3
Beta strandi358 – 364Combined sources7
Beta strandi370 – 376Combined sources7
Helixi384 – 387Combined sources4
Turni392 – 394Combined sources3
Helixi399 – 407Combined sources9
Helixi410 – 425Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5US8X-ray2.15A/B1-445[»]
ProteinModelPortaliQ7VTJ9
SMRiQ7VTJ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDH Bacteria
COG0137 LUCA
HOGENOMiHOG000230094
KOiK01940
OMAiGVGRIDM

Family and domain databases

Gene3Di1.10.287.400, 1 hit
3.40.50.620, 2 hits
3.90.1260.10, 2 hits
HAMAPiMF_00581 Arg_succ_synth_type2, 1 hit
InterProiView protein in InterPro
IPR023437 Arg_succ_synth_type2_subfam
IPR001518 Arginosuc_synth
IPR018223 Arginosuc_synth_CS
IPR024074 AS_cat/multimer_dom_body
IPR024073 AS_multimer_C_tail
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR11587 PTHR11587, 1 hit
PfamiView protein in Pfam
PF00764 Arginosuc_synth, 1 hit
TIGRFAMsiTIGR00032 argG, 1 hit
PROSITEiView protein in PROSITE
PS00564 ARGININOSUCCIN_SYN_1, 1 hit
PS00565 ARGININOSUCCIN_SYN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q7VTJ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTILPNLPT GQKVGIAFSG GLDTSAALLW MRQKGAVPYA YTANLGQPDE
60 70 80 90 100
PDYDEIPRRA MQYGAEAARL VDCRAQLVAE GIAALQAGAF HISTAGLTYF
110 120 130 140 150
NTTPIGRAVT GTMLVAAMKE DGVNIWGDGS TFKGNDIERF YRYGLLTNPD
160 170 180 190 200
LKIYKPWLDQ TFIDELGGRA EMSEYMRQAG FDYKMSAEKA YSTDSNMLGA
210 220 230 240 250
THEAKDLELL SAGIRIVQPI MGVAFWQDSV QIKAEEVTVR FEEGQPVALN
260 270 280 290 300
GVEYADPVEL LLEANRIGGR HGLGMSDQIE NRIIEAKSRG IYEAPGLALL
310 320 330 340 350
FIAYERLVTG IHNEDTIEQY RENGRKLGRL LYQGRWFDPQ AIMLRETAQR
360 370 380 390 400
WVARAITGEV TLELRRGNDY SLLNTESANL TYAPERLSME KVENAPFTPA
410 420 430 440
DRIGQLTMRN LDIVDTREKL FTYVKTGLLA PSAGSALPQI KDGKK
Length:445
Mass (Da):49,323
Last modified:October 1, 2003 - v1
Checksum:i81278F1EBC07CE61
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640421 Genomic DNA Translation: CAE43796.1
RefSeqiNP_882052.1, NC_002929.2
WP_003820367.1, NC_002929.2

Genome annotation databases

EnsemblBacteriaiCAE43796; CAE43796; BP3537
GeneIDi2664934
KEGGibpe:BP3537
PATRICifig|257313.5.peg.3829

Similar proteinsi

Entry informationi

Entry nameiASSY_BORPE
AccessioniPrimary (citable) accession number: Q7VTJ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: October 1, 2003
Last modified: May 23, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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