Q7VTJ8 (OTC_BORPE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ornithine carbamoyltransferase
Short name=OTCase
EC=2.1.3.3

Gene names

Name:	argF
Ordered Locus Names:	BP3538

Organism

Bordetella pertussis

Taxonomic identifier

520 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length	313 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 1/3. HAMAP MF_01109
Subcellular location	Cytoplasm Probable HAMAP MF_01109.
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	ornithine carbamoyltransferase complex Inferred from electronic annotation. Source: InterPro
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro ornithine carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 313	313	Ornithine carbamoyltransferase HAMAP MF_01109		PRO_0000112893
Regions
	Region	61 – 65	5	Carbamoyl phosphate binding By similarity
	Region	267 – 270	4	Ornithine binding By similarity
Sites
	Binding site	112	1	Carbamoyl phosphate By similarity
	Binding site	139	1	Carbamoyl phosphate By similarity
	Site	36	1	Important for structural integrity By similarity
	Site	152	1	Important for structural integrity By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7VTJ8 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 8A40E9FAA11C7DA3	FASTA	313	35,134
	10 20 30 40 50 60 MTPPTTQNGP LRHFLQFKDF SPAEIAYVLE RTRIIKDKFK RYEPHMPLHD RTLAMVFEKA 70 80 90 100 110 120 STRTRVSFEA GMYQMGGSVI NLTSNDSQLG RSEPIEDTAR VISRMVDIVM IRTFEQTRIE 130 140 150 160 170 180 RFASHSRVPV INGLTNEYHP CQILADIFTY IEHRGPIAGK TVAWIGDANN MSYTWLQAAE 190 200 210 220 230 240 MLGFTLHVST PAGYELDPAR IGAPAAGVLK QFKDPMQACQ GAHLVTTDVW TSMGYEAENE 250 260 270 280 290 300 ERRAAFADWC VDAEMMAAAD PQAVFMHCLP AHRGEEVTGE VIDGAQSVVW DEAENRLHVQ 310 KALMEFLLLG QLA

References

[1]

"Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica." Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S. , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J. Nat. Genet. 35:32-40(2003) [PubMed: 12910271] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tohama I / ATCC BAA-589 / NCTC 13251.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX640421 Genomic DNA. Translation: CAE43797.1.
RefSeq	NP_882053.1. NC_002929.2.
3D structure databases
ProteinModelPortal	Q7VTJ8.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2665146.
GenomeReviews	Gene locus BP3538 in contig BX470248_GR.
KEGG	bpe:BP3538.
PATRIC	21160730. VBIBorPer7866_3830.
Phylogenomic databases
HOGENOM	HBG579429.
OMA	GVDCVVT.
PhylomeDB	Q7VTJ8.
ProtClustDB	PRK00779.
Enzyme and pathway databases
BioCyc	BPER257313:BP3538-MONOMER.
Family and domain databases
HAMAP	MF_01109. OTCase. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002292. Orn/put_carbamltrans. IPR024904. Orn_carbamltrans. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00102. OTCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00658. Orni_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OTC_BORPE

Accession

Primary (citable) accession number: Q7VTJ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 7, 2004
Last sequence update:	October 1, 2003
Last modified:	January 25, 2012
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program