Q7VT93 (AROB_BORPE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-dehydroquinate synthase
EC=4.2.3.4

Gene names

Name:	aroB
Ordered Locus Names:	BP3657

Organism

Bordetella pertussis

Taxonomic identifier

520 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length	358 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110
Cofactor	NAD By similarity. HAMAP MF_00110 Divalent metal cations By similarity. HAMAP MF_00110
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110
Subunit structure	Monomer By similarity. HAMAP MF_00110
Subcellular location	Cytoplasm Probable HAMAP MF_00110.
Sequence similarities	Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-dehydroquinate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 358	358	3-dehydroquinate synthase HAMAP MF_00110		PRO_0000140713

Sequences

	Sequence		Length	Mass (Da)
	Q7VT93 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 1DE3968A9E6EFE6A	FASTA	358	38,104
	10 20 30 40 50 60 MDVVEVATPG GSYPIHIGPG RLDALDASIP ADATAIAVVT NPTVAGLYGA RVEAALARTG 70 80 90 100 110 120 KRVLRIELPD GEAHKDWQTL NLIFDALLEN RLDRRAVLVA LGGGVIGDMT GFAAAVYMRG 130 140 150 160 170 180 IRFVQVPTTL LAQVDSSVGG KTAVNHPLGK NMIGAFYQPV AVEIDTEVLG TLPAREVSAG 190 200 210 220 230 240 LAEVIKYGLI LDAGFWQWCE DNVGALRALE PRALAYAIRR SCELKAQVVG QDERESGLRA 250 260 270 280 290 300 ILNLGHTFGH AIESGLGYGE WLHGEAVGCG MVQAAELSTL AAGFPAADVQ RVRDLVREIG 310 320 330 340 350 CPTVAPDLGA ERWLALMQVD KKTEGGEIRF VLMPRIGQAL SRAAPEADVR TALERTTR

References

[1]

"Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica." Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S. , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J. Nat. Genet. 35:32-40(2003) [PubMed: 12910271] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tohama I / ATCC BAA-589 / NCTC 13251.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX640422 Genomic DNA. Translation: CAE43914.1.
RefSeq	NP_882165.1. NC_002929.2.
3D structure databases
ProteinModelPortal	Q7VT93.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2664959.
GenomeReviews	Gene locus BP3657 in contig BX470248_GR.
KEGG	bpe:BP3657.
PATRIC	21160980. VBIBorPer7866_3955.
Phylogenomic databases
HOGENOM	HBG632303.
OMA	WMRGVRV.
PhylomeDB	Q7VT93.
ProtClustDB	PRK00002.
Enzyme and pathway databases
BioCyc	BPER257313:BP3657-MONOMER.
Family and domain databases
HAMAP	MF_00110. DHQ_synthase. [Tree]
InterPro	IPR016037. DHQ_synth_AroB. [Graphical view]
KO	K01735.
PANTHER	PTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PIRSF	PIRSF001455. DHQ_synth. 1 hit.
TIGRFAMs	TIGR01357. AroB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROB_BORPE

Accession

Primary (citable) accession number: Q7VT93

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 2003
Last sequence update:	October 1, 2003
Last modified:	January 25, 2012
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program