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Q7VSZ1

- HISX_BORPE

UniProt

Q7VSZ1 - HISX_BORPE

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Protein
Histidinol dehydrogenase
Gene
hisD, BP3768
Organism
Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei133 – 1331NAD By similarity
Binding sitei194 – 1941NAD By similarity
Binding sitei217 – 2171NAD By similarity
Binding sitei240 – 2401Substrate By similarity
Metal bindingi262 – 2621Zinc By similarity
Binding sitei262 – 2621Substrate By similarity
Metal bindingi265 – 2651Zinc By similarity
Binding sitei265 – 2651Substrate By similarity
Active sitei330 – 3301Proton acceptor By similarity
Active sitei331 – 3311Proton acceptor By similarity
Binding sitei331 – 3311Substrate By similarity
Metal bindingi364 – 3641Zinc By similarity
Binding sitei364 – 3641Substrate By similarity
Binding sitei418 – 4181Substrate By similarity
Metal bindingi423 – 4231Zinc By similarity
Binding sitei423 – 4231Substrate By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciBPER257313:BP3768-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:BP3768
OrganismiBordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Taxonomic identifieri257313 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
ProteomesiUP000002676: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 434434Histidinol dehydrogenaseUniRule annotation
PRO_0000135738Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi257313.BP3768.

Structurei

3D structure databases

ProteinModelPortaliQ7VSZ1.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiCAIANRI.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7VSZ1-1 [UniParc]FASTAAdd to Basket

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MALINRLDSR DPGFKTALSQ LLAFEAEQDE SIDQAAAGIL ADVRRRGDAA    50
LLEYTQRFDR LAVDDATALE IPQADWHAAL DSLPAAQRQA LEAAAARVRA 100
YHERQRGETW TYTEADGTML GQQITALDRV GLYVPGGKAA YPSSVLMNAI 150
PAKVAGVPEL IMVTPTPDGV RNPIVLAAAA IAGVDRAFAI GGAQAVGALA 200
YGTATVPAVD KIVGPGNAYV AAAKRRVFGT VGIDMIAGPS EILVICDGKT 250
PADWIAMDLF SQAEHDELAQ SILLCPDAAF LAEVEAAIER LLPGMPRADI 300
LRVSLANRGA LILVRDLEEA CAIANDIAPE HLEISTEQPQ RWTALIRHAG 350
AIFMGRYSSE ALGDYCAGPN HVLPTSRTAR FSSPLGVYDF QKRSSLIQVS 400
REGAQTLGRI AAELALGEGL QAHAASAQYR LDQP 434
Length:434
Mass (Da):46,136
Last modified:October 1, 2003 - v1
Checksum:iD2D494FB6AE5EB6A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX640422 Genomic DNA. Translation: CAE44024.1.
RefSeqiNP_882269.1. NC_002929.2.

Genome annotation databases

EnsemblBacteriaiCAE44024; CAE44024; BP3768.
GeneIDi2665051.
KEGGibpe:BP3768.
PATRICi21161216. VBIBorPer7866_4072.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX640422 Genomic DNA. Translation: CAE44024.1 .
RefSeqi NP_882269.1. NC_002929.2.

3D structure databases

ProteinModelPortali Q7VSZ1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257313.BP3768.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE44024 ; CAE44024 ; BP3768 .
GeneIDi 2665051.
KEGGi bpe:BP3768.
PATRICi 21161216. VBIBorPer7866_4072.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi CAIANRI.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci BPER257313:BP3768-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica."
    Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S.
    , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J.
    Nat. Genet. 35:32-40(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tohama I / ATCC BAA-589 / NCTC 13251.

Entry informationi

Entry nameiHISX_BORPE
AccessioniPrimary (citable) accession number: Q7VSZ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: October 1, 2003
Last modified: May 14, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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