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Protein

Histidinol-phosphate aminotransferase 2

Gene

hisC2

Organism
Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate.

Cofactori

Pathwayi: L-histidine biosynthesis

This protein is involved in step 7 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG), ATP phosphoribosyltransferase regulatory subunit (hisZ)
  2. Phosphoribosyl-ATP pyrophosphatase (hisE)
  3. Phosphoribosyl-AMP cyclohydrolase (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisH (hisH), Imidazole glycerol phosphate synthase subunit HisF (hisF)
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. Histidinol-phosphate aminotransferase 1 (hisC1), Histidinol-phosphate aminotransferase 2 (hisC2)
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
Biological processAmino-acid biosynthesis, Histidine biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciBPER257313:BP3769_1-MONOMER
UniPathwayiUPA00031; UER00012

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol-phosphate aminotransferase 2 (EC:2.6.1.9)
Alternative name(s):
Imidazole acetol-phosphate transaminase 2
Gene namesi
Name:hisC2
Ordered Locus Names:BP3769
OrganismiBordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Taxonomic identifieri257313 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
Proteomesi
  • UP000002676 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001533241 – 365Histidinol-phosphate aminotransferase 2Add BLAST365

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei222N6-(pyridoxal phosphate)lysineBy similarity1

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi257313.BP3769

Structurei

3D structure databases

ProteinModelPortaliQ7VSZ0
SMRiQ7VSZ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CIH Bacteria
COG0079 LUCA
HOGENOMiHOG000288510
KOiK00817
OMAiTYGMYKV

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_01023 HisC_aminotrans_2, 1 hit
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR005861 HisP_aminotrans
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR01141 hisC, 1 hit

Sequencei

Sequence statusi: Complete.

Q7VSZ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGVAAPERI ARAVRADIRA LTAYPVADAA GCIKLDAMEC PYELPAEVRD
60 70 80 90 100
DIARAARETP LNRYPAAANP ALQAQVRQAF EVPAQAGLLF GNGSDELIHL
110 120 130 140 150
IIQACCEPGD TVLSPWPSFV YFDMAARLSH ARFVGVPLTA GLELDLPATL
160 170 180 190 200
AAIEAHQPKV VFLALPNNPT GDLWPDAAVR AILDAAPGLV VLDEAYQPFA
210 220 230 240 250
GHTWMPRIMD EPNAVVMRTV SKIGLAGLRF GYLAGHPAWI AEFDKVRPPY
260 270 280 290 300
NMDVLSQAVL AAVLRHKPVL DAQADRLRAD RQPLADGLAA LPGVTVFPSA
310 320 330 340 350
GNFVLARFCG KLDGNAVHLA PKTRKILVRN FSNAHPLLAD CLRISVGTPT
360
ENAAVLSALQ DILSA
Length:365
Mass (Da):39,027
Last modified:October 1, 2003 - v1
Checksum:iB7107A1F9F51C17F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640422 Genomic DNA Translation: CAE44025.1
RefSeqiNP_882270.1, NC_002929.2
WP_010931642.1, NC_002929.2

Genome annotation databases

EnsemblBacteriaiCAE44025; CAE44025; BP3769
GeneIDi2665052
KEGGibpe:BP3769
PATRICifig|257313.5.peg.4073

Similar proteinsi

Entry informationi

Entry nameiHIS82_BORPE
AccessioniPrimary (citable) accession number: Q7VSZ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: October 1, 2003
Last modified: June 20, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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