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Q7VS76 (ASPD1_BORPE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable L-aspartate dehydrogenase 1
EC=1.4.1.21
Gene names
Name:nadX1
Ordered Locus Names:BP0567
OrganismBordetella pertussis
Taxonomic identifier520 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length258 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate By similarity. HAMAP MF_01265

Catalytic activity

L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H. HAMAP MF_01265

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (dehydrogenase route): step 1/1. HAMAP MF_01265

Miscellaneous

The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia By similarity. HAMAP MF_01265

Sequence similarities

Belongs to the L-aspartate dehydrogenase family.

Ontologies

Keywords
   Biological processPyridine nucleotide biosynthesis
   LigandNAD
NADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processNAD biosynthetic process

Inferred from electronic annotation. Source: InterPro

NADP catabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionNADP binding

Inferred from electronic annotation. Source: InterPro

aspartate dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 258258Probable L-aspartate dehydrogenase 1 HAMAP MF_01265
PRO_0000144885

Sites

Active site2111 By similarity
Binding site1211NAD; via amide nitrogen By similarity
Binding site1811NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7VS76 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: A4F8E4FD19D68C29

FASTA25826,316
        10         20         30         40         50         60 
MNTPLRVGIV GCGVLANAMA GHLARQPRPV EIVGCLVRDP GRARGALPCH GSWEALLAQR 

        70         80         90        100        110        120 
PDVVVECAGQ AALAQYAQAI LAAGVDLVPA SVGALADDAL RGALLEAAAA AGARIRIPSG 

       130        140        150        160        170        180 
AMVGIDGLAA ARHVGVAEVL YRGTMPPVAL QRYVSGPLPE RGLAFAGSAR EAVARFPKNV 

       190        200        210        220        230        240 
NLTGTIALAG IGFDRTRVEM LIDPDATANV HELLARGEFG DFHARVSGLR ISESSPSSRI 

       250 
VAGSLAQAAL GSGFLALS

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX640412 Genomic DNA. Translation: CAE44895.1.
RefSeqNP_879414.1. NC_002929.2.

3D structure databases

ProteinModelPortalQ7VS76.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2664063.
GenomeReviewsGene locus BP0567 in contig BX470248_GR.
KEGGbpe:BP0567.
NMPDRfig|257313.1.peg.493.
PATRIC21154204. VBIBorPer7866_0609.

Phylogenomic databases

HOGENOMHBG649642.
OMAANAMAGH.
ProtClustDBPRK13303.

Enzyme and pathway databases

BioCycBPER257313:BP0567-MONOMER.

Family and domain databases

HAMAPMF_01265. NadX.
[Tree]
InterProIPR005106. Asp/hSer_DH_NAD-bd.
IPR002811. Asp_DH.
IPR011182. Asp_DH_NAD_syn.
IPR020626. Asp_DH_NAD_syn_prok.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK06989.
PfamPF01958. DUF108. 1 hit.
PF03447. NAD_binding_3. 1 hit.
[Graphical view]
PIRSFPIRSF005227. Asp_dh_NAD_syn. 1 hit.
ProtoNetSearch...

Entry information

Entry nameASPD1_BORPE
AccessionPrimary (citable) accession number: Q7VS76
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: October 1, 2003
Last modified: January 25, 2012
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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