UniProtKB - Q7VRZ3 (GLMS_BORPE)
(max 400 entries)x
Your basket is currently empty. i
Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)
Protein
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]
Gene
glmS
Organism
Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Status
Functioni
Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation
Catalytic activityi
L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 2 | Nucleophile; for GATase activityUniRule annotation | 1 | |
Active sitei | 605 | For Fru-6P isomerization activityUniRule annotation | 1 |
GO - Molecular functioni
- carbohydrate derivative binding Source: InterPro
- glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-EC
GO - Biological processi
- carbohydrate derivative biosynthetic process Source: InterPro
- glutamine metabolic process Source: UniProtKB-KW
Keywordsi
Molecular function | Aminotransferase, Transferase |
Enzyme and pathway databases
BioCyci | BPER257313:G1GSZ-789-MONOMER. |
Names & Taxonomyi
Protein namesi | Recommended name: Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)Alternative name(s): D-fructose-6-phosphate amidotransferaseUniRule annotation GFATUniRule annotation Glucosamine-6-phosphate synthaseUniRule annotation Hexosephosphate aminotransferaseUniRule annotation L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation |
Gene namesi | Name:glmSUniRule annotation Ordered Locus Names:BP0666 |
Organismi | Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251) |
Taxonomic identifieri | 257313 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedUniRule annotation | |||
ChainiPRO_0000135306 | 2 – 610 | Glutamine--fructose-6-phosphate aminotransferase [isomerizing]Add BLAST | 609 |
Interactioni
Subunit structurei
Homodimer.UniRule annotation
Protein-protein interaction databases
STRINGi | 257313.BP0666. |
Structurei
3D structure databases
ProteinModelPortali | Q7VRZ3. |
SMRi | Q7VRZ3. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 221 | Glutamine amidotransferase type-2UniRule annotationAdd BLAST | 220 | |
Domaini | 286 – 426 | SIS 1UniRule annotationAdd BLAST | 141 | |
Domaini | 459 – 600 | SIS 2UniRule annotationAdd BLAST | 142 |
Keywords - Domaini
Glutamine amidotransferase, RepeatPhylogenomic databases
eggNOGi | ENOG4105C46. Bacteria. COG0449. LUCA. |
HOGENOMi | HOG000258898. |
KOi | K00820. |
OMAi | RLDSSTC. |
Family and domain databases
CDDi | cd05008. SIS_GlmS_GlmD_1. 1 hit. cd05009. SIS_GlmS_GlmD_2. 1 hit. |
Gene3Di | 3.60.20.10. 1 hit. |
HAMAPi | MF_00164. GlmS. 1 hit. |
InterProi | View protein in InterPro IPR017932. GATase_2_dom. IPR035466. GlmS/AgaS_SIS. IPR035490. GlmS/FrlB_SIS. IPR005855. GlmS_trans. IPR029055. Ntn_hydrolases_N. IPR001347. SIS. |
PANTHERi | PTHR10937:SF0. PTHR10937:SF0. 1 hit. |
Pfami | View protein in Pfam PF01380. SIS. 2 hits. |
SUPFAMi | SSF56235. SSF56235. 1 hit. |
TIGRFAMsi | TIGR01135. glmS. 1 hit. |
PROSITEi | View protein in PROSITE PS51278. GATASE_TYPE_2. 1 hit. PS51464. SIS. 2 hits. |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q7VRZ3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MCGIVGAVAQ RDITPILIEG LKRLEYRGYD SCGVALYMDG HLRRTRSTKR
60 70 80 90 100
VAELSEQVAE DKLGGFTGIA HTRWATHGIP ATYNAHPHFS AQGKDEPRIA
110 120 130 140 150
LVHNGIIENH EELRQELQGV GYVFESQTDT EVIAHLVNHL YAGDLFEAVQ
160 170 180 190 200
QAVRRLQGAY AIAVFCRDEP HRVVGARQGS PLVVGLGQNE NFLASDALAL
210 220 230 240 250
AGTTDQIIYL EDGDVVDLQL ARVWIVDQAG KQVERKAHTV QVHTGAAELG
260 270 280 290 300
PYRHFMQKEI FEQPRAVGDT LQDIESITPE LFGDGAYKVF KEIDSLLILA
310 320 330 340 350
CGTSYYAGLT AKYWIESIAR IPVAVEIASE YRYRDSVPNP NALVVTISQS
360 370 380 390 400
GETADTLAAL KHVRSLGMQH TLTVCNVVTS AMVRECELAY ITRAGVEIGV
410 420 430 440 450
ASTKAFTTQL TALFLLTLAL AQTRGRLTEE QEAEHLKALR HLPAAIGAVL
460 470 480 490 500
ALEPQIMAWA DRFASKENAL FLGRGMHYPI ALEGALKLKE ISYIHAEAYP
510 520 530 540 550
AGELKHGPLA LVTEHMPVVT IAPKDALLEK LKSNMQEVRA RGGELYVFAD
560 570 580 590 600
ADSKIANAEG MHVIRMPEYY GALSPIVHTI PLQLLSYHTA CVRGTDVDKP
610
RNLAKSVTVE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX640412 Genomic DNA. Translation: CAE44992.1. |
RefSeqi | NP_879503.1. NC_002929.2. WP_010929946.1. NC_002929.2. |
Genome annotation databases
EnsemblBacteriai | CAE44992; CAE44992; BP0666. |
GeneIDi | 2667728. |
KEGGi | bpe:BP0666. |
PATRICi | fig|257313.5.peg.713. |
Similar proteinsi
Entry informationi
Entry namei | GLMS_BORPE | |
Accessioni | Q7VRZ3Primary (citable) accession number: Q7VRZ3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 30, 2005 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 28, 2018 | |
This is version 90 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |